The medial superior genicular runs in front of the Semimembranosus and Semitendinosus, above the medial head of the Gastrocnemius, and passes beneath the tendon of the Adductor magnus.

It divides into two branches, one of which supplies the vastus medialis

Vastus medialis

The vastus medialis , often called the 'teardrop' muscle, is a medially located muscle of the quadriceps.-Function:The vasti appear to act largely in a co-ordinated manner throughout the control of knee extension...

, anastomosing with the highest genicular and medial inferior genicular arteries; the other ramifies close to the surface of the femur, supplying it and the knee-joint, and anastomosing with the lateral superior genicular artery.

The medial superior genicular artery is frequently of small size, a condition, which is associated with an increase in the size of the highest genicular.