Suppressor of cytokine signaling 1
Encyclopedia
Suppressor of cytokine signaling 1 is a protein
that in humans is encoded by the SOCS1 gene
. SOCS1 orthologs have been identified in several mammals for which complete genome data are available.
with Janus kinase 2
, Growth hormone receptor
, CD117
, IRS2
, Colony stimulating factor 1 receptor
and TEC
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the SOCS1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. SOCS1 orthologs have been identified in several mammals for which complete genome data are available.
Interactions
Suppressor of cytokine signaling 1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Janus kinase 2
Janus kinase 2
Janus kinase 2 is a human protein that has been implicated in signaling by members of the type II cytokine receptor family , the GM-CSF receptor family , the gp130 receptor family , and the single chain receptors...
, Growth hormone receptor
Growth hormone receptor
Growth hormone receptor is a protein that in humans is encoded by the GHR gene. GHR orthologs have been identified in most mammals.-Interactions:...
, CD117
CD117
Mast/stem cell growth factor receptor also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117 is a protein that in humans is encoded by the KIT gene...
, IRS2
IRS2
Insulin receptor substrate 2 is a protein that in humans is encoded by the IRS2 gene.. Mice lacking IRS2 have a diabetic phenotype as well as a 40% reduction in brain mass.-Interactions:...
, Colony stimulating factor 1 receptor
Colony stimulating factor 1 receptor
Colony stimulating factor 1 receptor , also known as macrophage colony-stimulating factor receptor , and CD115 , is a cell-surface protein encoded, in humans, by the CSF1R gene...
and TEC
TEC (gene)
Tyrosine-protein kinase Tec is an enzyme that in humans is encoded by the TEC gene.-Interactions:TEC has been shown to interact with GNA12, Janus kinase 2, CD117, Suppressor of cytokine signaling 1, ARHGEF12 and DOK1.-Further reading:...
.