Swyer-James syndrome
Encyclopedia
Swyer James syndrome is a rare lung
disorder found by Physicians Paul Robert Swyer, William Mathiseon Macleod and Radiologist George James in the 1950's in Canada. At the same time J. Bret was exploring this illness in France
, and consequently it is sometimes referred to as Brett's syndrome.
Swyer-James syndrome is a manifestation of postinfectious obliterative bronchiolitis. In SJS, the involved lung
or portion of the lung does not grow normally and is slightly smaller than the opposite lung. The characteristic radiographic appearance is that of pulmonary hyperlucency, caused by overdistention of the alveoli in conjunction with diminished arterial flow. and has been linked to adenovirus type 21
In appearance Swyer James normally leaves shadowing in a CT scan in the upper lobar regions of one or (rarely) both lungs. Patients with the illness operate in much the same way as patients with mild bronchiectasis
. As a result the illness can go undiagnosed for some time. With current developments in the pharmaceutical industry, the prognosis is good for sufferers of the illness to lead normal and healthy lives. Particular attention must be paid to the new development of Erdosteine
from Italy, which is becoming increasingly available across the world.
Lung
The lung is the essential respiration organ in many air-breathing animals, including most tetrapods, a few fish and a few snails. In mammals and the more complex life forms, the two lungs are located near the backbone on either side of the heart...
disorder found by Physicians Paul Robert Swyer, William Mathiseon Macleod and Radiologist George James in the 1950's in Canada. At the same time J. Bret was exploring this illness in France
France
The French Republic , The French Republic , The French Republic , (commonly known as France , is a unitary semi-presidential republic in Western Europe with several overseas territories and islands located on other continents and in the Indian, Pacific, and Atlantic oceans. Metropolitan France...
, and consequently it is sometimes referred to as Brett's syndrome.
Swyer-James syndrome is a manifestation of postinfectious obliterative bronchiolitis. In SJS, the involved lung
Lung
The lung is the essential respiration organ in many air-breathing animals, including most tetrapods, a few fish and a few snails. In mammals and the more complex life forms, the two lungs are located near the backbone on either side of the heart...
or portion of the lung does not grow normally and is slightly smaller than the opposite lung. The characteristic radiographic appearance is that of pulmonary hyperlucency, caused by overdistention of the alveoli in conjunction with diminished arterial flow. and has been linked to adenovirus type 21
In appearance Swyer James normally leaves shadowing in a CT scan in the upper lobar regions of one or (rarely) both lungs. Patients with the illness operate in much the same way as patients with mild bronchiectasis
Bronchiectasis
Bronchiectasis is a disease state defined by localized, irreversible dilation of part of the bronchial tree caused by destruction of the muscle and elastic tissue. It is classified as an obstructive lung disease, along with emphysema, bronchitis, asthma, and cystic fibrosis...
. As a result the illness can go undiagnosed for some time. With current developments in the pharmaceutical industry, the prognosis is good for sufferers of the illness to lead normal and healthy lives. Particular attention must be paid to the new development of Erdosteine
Erdosteine
Erdosteine is a mucolytic. Specifically it is a thiol derivative developed for the treatment of chronic obstructive bronchitis, including acute infective exacerbation of chronic bronchitis. Erdosteine contains two blocked sulfhydryl groups which are released following first-pass metabolism. The...
from Italy, which is becoming increasingly available across the world.
Sources
- http://radiology.rsnajnls.org/cgi/content/abstract/172/2/477
- http://www.mevis.de/~hhj/Lunge/imaMb/mb_ism_swjs_a.htm
- P. R. Swyer, G. C. W. James (1953), "A case of unilateral pulmonary emphysema" in Thorax, London, 8: 133-136
- W. M. Macleod (1954), "Abnormal transradiancy of one lung" in Thorax, London, 9: 147-153.