Synaptic noise
Encyclopedia
Synaptic noise describes the continuous and noisy "bombardment" of central neurons by synaptic inputs, especially in vivo
. In particular, the cerebral cortex in vivo is characterized by sustained and irregular neuronal activity, which combined with the very high cortical interconnectivity, is responsible for a considerable and noisy synaptic activity in any given cortical neuron. Intracellular
recordings of the membrane potential have characterized this intense activity, which sets neurons into a high-conductance state (because of the large number of synaptic inputs, each of which evokes a conductance increase in the membrane). Numerous computational models and theoretical studies have investigated high-conductance states and synaptic noise, and found numerous consequences on neuronal processing; the presence of synaptic noise may fundamentally change the integrative properties of neurons, and even may confer several computational advantages for information processing (see details in the articles High-Conductance State and Neuronal Noise in Scholarpedia
).
In vivo
In vivo is experimentation using a whole, living organism as opposed to a partial or dead organism, or an in vitro controlled environment. Animal testing and clinical trials are two forms of in vivo research...
. In particular, the cerebral cortex in vivo is characterized by sustained and irregular neuronal activity, which combined with the very high cortical interconnectivity, is responsible for a considerable and noisy synaptic activity in any given cortical neuron. Intracellular
Intracellular
Not to be confused with intercellular, meaning "between cells".In cell biology, molecular biology and related fields, the word intracellular means "inside the cell".It is used in contrast to extracellular...
recordings of the membrane potential have characterized this intense activity, which sets neurons into a high-conductance state (because of the large number of synaptic inputs, each of which evokes a conductance increase in the membrane). Numerous computational models and theoretical studies have investigated high-conductance states and synaptic noise, and found numerous consequences on neuronal processing; the presence of synaptic noise may fundamentally change the integrative properties of neurons, and even may confer several computational advantages for information processing (see details in the articles High-Conductance State and Neuronal Noise in Scholarpedia
Scholarpedia
Scholarpedia is an English-language online wiki-based encyclopedia that uses the same MediaWiki software as Wikipedia, but has features more commonly associated with open-access online academic journals....
).
External links
- High-Conductance State article in ScholarpediaScholarpediaScholarpedia is an English-language online wiki-based encyclopedia that uses the same MediaWiki software as Wikipedia, but has features more commonly associated with open-access online academic journals....
- Neuronal Noise article in ScholarpediaScholarpediaScholarpedia is an English-language online wiki-based encyclopedia that uses the same MediaWiki software as Wikipedia, but has features more commonly associated with open-access online academic journals....