Szilard Voros
Encyclopedia
Szilard Voros is a Hungarian-born American cardiologist and globally renowned leading research scientist in advanced cardiovascular imaging. He currently serves as the Chief Scientific Officer, Chief of Cardiovascular Prevention, and Medical Director of Cardiac MR and CT at Piedmont Hospital in Atlanta, Georgia, and as a Clinical Associate Professor of Medicine at the Medical College of Georgia. He is a founding member and Fellow of the Society of Cardiovascular Computed Tomography (FSCCT), and a Fellow of the American College of Cardiology (FACC).
In 2008, Fox 7 News aired a Health Edge special on The Family Heart Disease Program, a Voros led initiative that identified family
members at high risk of developing coronary artery disease and educated them on how to reduce the risks for themselves
and their families.
Most recently, Voros was interviewed on Fox 5 News for a Health Watch special on the Corus CAD test,a blood-based test that measures the expression levels of 23 genes that have demonstrated to indicate obstructive coronary artery disease (CAD).
Dr. Voros has published extensively in the field of advanced cardiovascular imaging. He regularly lectures at national and international meetings, including many prestigious conferences sponsored by the American College of Cardiology. Working with CardioDx, he recently published a paper in the Annals of Internal Medicine describing the first genomic blood-based diagnostic test for the detection of significant blockages in the heart. Dr. Voros is independently funded to do important clinical research on advanced cardiovascular imaging, atherosclerosis and lipoprotein abnormalities. Dr. Voros and his team recently completed the ATLANTA I and ATLANTA II studies, which focused on assessing the morphology and other characteristics of blockages in the heart using heart catherization, cardiac CT, intravascular ultrasound, and near infrared spectroscopy. Currently, his team is running several clinical trials in preventive cardiology, including DECIDE CTA, iCARE, and AFRICA.
In 2010, Voros and his team published an article on their advanced method of coronary artery calcium quantification, the Lesion Specific Calcium Score
. This method has been shown, through research, to be superior to the Agatston Score
.
Thakur AC, Voros S, Nanda NC, Gomez CR, Terry JB, Tulyapronchote R, Ocak O: Transesophageal Echocardiographic Diagnosis of Proximal Coronary Artery Stenosis in Patients with Ischemic Stroke. Echocardiography 1999(16):159-165.
Nanda NC, Thakur AC, Thakur D, Narayan VK, Espinal MA, Shoeb G, Samal AK, Voros S, Aaluri SR, Ocak O, John AS, Pasia AT, Aikens M.
Transesophageal echocardiographic examination of left subclavian artery branches. Echocardiography 1999(16):271-277.
Voros S, Nanda NC, Thakur AC, Winokur TS, Samal AK: Lambl's excrescences (Valvular Strands). Echocardiography 1999(16):399-413.
Samal AK, Nanda NC, Thakur AC, Narayan VK, Ocak O, Lee TY, Voros S, Jindal A, Winokur TS. Three-Dimensional Echocardiographic Assessment of Lambl's Excrescences on the Aortic Valve. Echocardiography 1999(16):437-441.
Voros S, Nanda NC. Transesophageal Echocardiographic Assessment of Proximal Coronary Artery Stenosis in Elderly Patients with Ischemic Stroke. Am J Geriatric Cardiol 2000;9(4):197-203.
Biederman RWW, Sorrell VL, Nanda NC, Voros S, Thakur AC. Transesophageal Echocardiographic Assessment of Coronary Stenosis: A Decade of Experience. Echocardiography 2001;18(1):49-57.
Voros S, Nanda NC, Samal AK, Gomez CR, Puri VK, Jindal A, Terry JB, Tulyapronchote R, Thakur AC. Transesophageal Echocardiography Performed in Stroke Patients to Exclude Cardiac Sources of Embolism Accurately Detects Significant Proximal Coronary Artery Stenosis and Often Changes Management. American Heart Journal 2001;142:916-922.
Voros S, Kramer CM. Clinical applications of cardiovascular magnetic resonance imaging. Heartwise 2003;6(4):4-10.
Keser N, Nanda NC, Miller AP, Voros S, Soydas C, Agrawal G, Liguori C, Naftel D, Pacifico AD, Kirklin JK, McGiffin DC, Holman WL. Hemodynamic Evaluation of Normally Functioning Sulzer Carbomedics Prosthetic Valves. Ultrasound Med Biol. 2003 May;29(5):649-57.
Patel RAG, Dimarco JP, Akar JG, Voros S, Kramer CM. Chagas myocarditis and syncope. J Cardiovasc Magn Reson, 2005;7:685-688.
Voros S, Kramer CM. “Cardiovascular MRI: State of the Art” in Clinical Cardiology Reviews, (Bentham Science Publishers, London) 2005;1:181-188.
Szilard Voros MD, Zequan Yang MD, PhD, Christina M. Bove MD, Wesley D. Gilson PhD, Frederick H. Epstein PhD, Brent A. French, PhD, Stuart S. Berr PhD, Sanford P. Bishop PhD, DVM, Hiroaki Matsubara MD, PhD, Robert M. Carey MD, Christopher M. Kramer MD, FACC. The AT2 Receptor Mediates Most of the Benefit of AT1 Receptor Blockade During Post-Infarction Left Ventricular Remodeling. Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1004-10. Epub 2005 Oct 7.
Bove CM, DiMaria JM, Voros S, Conaway MR, Kramer CM. Dobutamine Response and Myocardial Infarct Transmurality: Functional Improvement after Coronary Artery Bypass Grafting—Initial Experience. Radiology 2006;240(3):835-842.
Akram K, Silverman ME, Voros S. A Unique Case of Pulmonary Artery Leiomyosarcoma. J Natl Med Assoc. 2006;98(12):1995-96.
Interaction Between Bradykinin Subtype 2 and Angiotensin II Type 2 Receptors During Post-MI Left Ventricular Remodeling. Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3372-8.
Schietinger BJ, Voros S, Isbell DC, Meyer CH, Christopher JM, Kramer CM. Can late gadolinium enhancement by cardiovascular magnetic resonance identify coronary artery disease as the etiology of new onset congestive heart failure? Int J Cardiovasc Imaging. 2007 Oct;23(5):595-602.
Kamran Akram, Szilard Voros. Absolute Coronary Artery Calcium Scores are superior to MESA percentile rank in predicting obstructive coronary artery disease. Int J Cardiovasc Imaging. 2008 Oct;24(7):743-9.
Szilard Voros. Can Computed Tomography Angiography of the Coronary Arteries Characterize Atherosclerotic Plaque Composition? Is the CAT (Scan) Out of the Bag? J. Am. Coll. Cardiol. Intv. 2008;1;183-185.
Kamran Akram, Robert E. O’Donnell, Spencer King, H. Robert Superko, Arthur Agatston, Szilard Voros. Influence of Symptomatic Status on the Prevalence of Obstructive Coronary Artery Disease in Patients with Zero Calcium Score. Atherosclerosis 2009;203:533–537.
Akram K, Voros S. Influence of symptoms and age on the predictive value of coronary artery calcium scanning. J Am Coll Cardiol. 2008 Dec 16;52(25):2214.
Akram K, Rinehart S, Voros S. Coronary arterial atherosclerotic plaque imaging by contrast-enhanced computed tomography: fantasy or reality? J Nucl Cardiol. 2008 Nov-Dec;15(6):818-29.
Voros S. What are the potential advantages and disadvantages of volumetric CT scanning? J Cardiovasc Comput Tomogr. 2009 Mar-Apr;3(2):67-70. Epub 2009 Jan 9.
Rinehart S, Vazquez G, Qian Z, Voros S. Coronary Plaque Imaging with Multi-Slice Computed Tomographic Angiography and Intravascular Ultrasound: A Close Look Inside and Out. J Inv Cardiol 2009; 21(7):367-372.
Qian Z, Marvasty I, Anderson H, Rinehart S, Voros S. Lesion-specific coronary artery calcium quantification better predicts cardiac events”. Proc. of IEEE International Symposium on Biomedical Imaging (ISBI), p237-240, 2009.
Akram K, Anderson HD, Voros S. Quantification of left ventricular parameters obtained by automated software for 64-slice multidetector computed tomography and comparison with magnetic resonance imaging. Cardiovasc Intervent Radiol. 2009 Nov;32(6):1154-60.
Voros S. "Does imaging paint a sugar-coated picture of diabetic vessels?" : plaque composition in diabetics by IVUS and CT angiography. J Nucl Cardiol. 2009 May-Jun;16(3):339-44. Epub 2009 Mar 10. No abstract available.
Voros S, Joshi PH, Vazquez G, Roth G, Murrieta L, Rinehart S, Qian Z, Miller J. Cardiovascular computed tomographic assessment of the effect of combination lipoprotein therapy on coronary arterial plaque: Rationale and design of the AFRICA (Atorvastatin plus Fenofibric acid in the Reduction of Intermediate Coronary Atherosclerosis) study. J Cardiovasc Comput Tomogr. 2010;4:164–172.
George Barbier, Jesus Gustavo Vazquez Figueroa, Sarah Rinehart, Zhen Qian, Parag Joshi, Charles Wilmer, Szilard Voros. Tissue Characterization of a Papillary Fibroelastoma on the Aortic Valve by Contrast-Enhanced 320-Detector Row Computed Tomography Accepted Manuscript, 7 June 2010. Journal of Cardiovascular Computed Tomography. DOI: 10.1016/j.jcct.2010.05.020
Zhen Qian, Hunt Anderson, Idean Marvasty, Kamran Akram, Gustavo Vazquez, Sarah Rinehart, Szilard Voros. Lesion- and Vessel-Specific Coronary Artery Calcium Scores are Superior to Whole-Heart Agatston and Volume Scores in the Diagnosis of Obstructive Coronary Artery Disease. Journal of Cardiovascular Computed Tomography. DOI: 10.1016/j.jcct.2010.09.001.
Sara Mobasseri, Szilard Voros. Clinical Trial Report: The Use of Coronary CT Angiography to Evaluate Chest Pain Patients—The ROMICAT (Rule Out Myocardial Infarction using Computer-Assisted Tomography) Study. Current Cardiovascular Imaging Reports. DOI: 10.1007/s12410-010-9051-7.
Rinehart S, Vazquez G, Qian Z, Murrieta L, Christian K, Voros S. Quantitative Measurements of Coronary Arterial Stenosis, Plaque Geometry and Composition are Highly Reproducible with a Standardized Coronary Arterial Computed Tomographic Approach in High-Quality CT Datasets. In Press. Journal of Cardiovascular Computed Tomography.
Rosenberg S, Elashoff MR, Beineke P, Daniels SE, Wingrove JA, Tingley WG, Sager PT, Sehnert AJ, Yau M, Kraus WE, Newby LK, Schwartz RS, Voros S, Ellis SG, Tahirkheli N, Waksman R, McPherson J, Lansky A, Winn ME, Schork NJ, Topol EJ. Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients. Ann Intern Med. 2010 Oct 5;153(7):425-34.
Prospective Validation of Standardized, 3-Dimensional, Quantitative Coronary Computed Tomographic Plaque Measurements Using Radiofrequency Backscatter Intravascular Ultrasound as Reference Standard in Intermediate Coronary Arterial Lesions Results From the ATLANTA (Assessment of Tissue Characteristics, Lesion Morphology, and Hemodynamics by Angiography With Fractional Flow Reserve, Intravascular Ultrasound and Virtual Histology, and Noninvasive Computed Tomography in Atherosclerotic Plaques) I Study.
Voros S, Rinehart S, Qian Z, Vazquez G, Anderson H, Murrieta L, Wilmer C, Carlson H, Taylor K, Ballard W, Karmpaliotis D, Kalynych A, Brown C 3rd. JACC Cardiovasc Interv. 2011 Feb;4(2):198-208. PMID: 21349459 [PubMed - in process].
Biography
In 1996, as a Summa Cum Laude graduate of the University Medical School of Pécs in Hungary, Dr. Voros moved to the United States to pursue his Internship and Residency in Internal Medicine at the University of Alabama at Birmingham from 1997 to 2000. During Dr. Voros' tenure at UAB, he also served as a consultant for Lockheed Martin in Echocardiography Training. In 2000,he was invited to serve as Clinical Instructor in Medicine and Chief Medical Resident. While at UAB, Dr. Voros was inspired to pursue Cardiology.Under the mentorship of Dr. Navin Nanda and Dr. Gerald Pohost, both globally renowned expert cardiologists and scientists in their respective specialties, Dr. Voros initiated his interest in cardiovascular imaging. As he would later discover, this interest would become his passion. Dr. Voros was one of the first handful of physicians who were Level III trained in Cardiovascular Magnetic Resonance Imaging and Computed Tomography.In 2008, Fox 7 News aired a Health Edge special on The Family Heart Disease Program, a Voros led initiative that identified family
members at high risk of developing coronary artery disease and educated them on how to reduce the risks for themselves
and their families.
Most recently, Voros was interviewed on Fox 5 News for a Health Watch special on the Corus CAD test,a blood-based test that measures the expression levels of 23 genes that have demonstrated to indicate obstructive coronary artery disease (CAD).
Dr. Voros has published extensively in the field of advanced cardiovascular imaging. He regularly lectures at national and international meetings, including many prestigious conferences sponsored by the American College of Cardiology. Working with CardioDx, he recently published a paper in the Annals of Internal Medicine describing the first genomic blood-based diagnostic test for the detection of significant blockages in the heart. Dr. Voros is independently funded to do important clinical research on advanced cardiovascular imaging, atherosclerosis and lipoprotein abnormalities. Dr. Voros and his team recently completed the ATLANTA I and ATLANTA II studies, which focused on assessing the morphology and other characteristics of blockages in the heart using heart catherization, cardiac CT, intravascular ultrasound, and near infrared spectroscopy. Currently, his team is running several clinical trials in preventive cardiology, including DECIDE CTA, iCARE, and AFRICA.
In 2010, Voros and his team published an article on their advanced method of coronary artery calcium quantification, the Lesion Specific Calcium Score
Lesion Specific Calcium Score
The Lesion-Specific Calcium Score is a method of calcium measurement that results from a CT Test for Coronary Artery Calcification.-Background:...
. This method has been shown, through research, to be superior to the Agatston Score
Agatston Score
The Agatston Score, named after Arthur Agatston, is a measure of calcium generally included in the results from a CT Test for Coronary Calcification....
.
Publications
Voros S, Nanda NC, Thakur AC, Narayan VK, Samal AK: Lambl's Excrescences Involving the Pulmonary Valve Detected by Transesophageal Echocardiography. Echocardiography, 1999(16):35-39.Thakur AC, Voros S, Nanda NC, Gomez CR, Terry JB, Tulyapronchote R, Ocak O: Transesophageal Echocardiographic Diagnosis of Proximal Coronary Artery Stenosis in Patients with Ischemic Stroke. Echocardiography 1999(16):159-165.
Nanda NC, Thakur AC, Thakur D, Narayan VK, Espinal MA, Shoeb G, Samal AK, Voros S, Aaluri SR, Ocak O, John AS, Pasia AT, Aikens M.
Transesophageal echocardiographic examination of left subclavian artery branches. Echocardiography 1999(16):271-277.
Voros S, Nanda NC, Thakur AC, Winokur TS, Samal AK: Lambl's excrescences (Valvular Strands). Echocardiography 1999(16):399-413.
Samal AK, Nanda NC, Thakur AC, Narayan VK, Ocak O, Lee TY, Voros S, Jindal A, Winokur TS. Three-Dimensional Echocardiographic Assessment of Lambl's Excrescences on the Aortic Valve. Echocardiography 1999(16):437-441.
Voros S, Nanda NC. Transesophageal Echocardiographic Assessment of Proximal Coronary Artery Stenosis in Elderly Patients with Ischemic Stroke. Am J Geriatric Cardiol 2000;9(4):197-203.
Biederman RWW, Sorrell VL, Nanda NC, Voros S, Thakur AC. Transesophageal Echocardiographic Assessment of Coronary Stenosis: A Decade of Experience. Echocardiography 2001;18(1):49-57.
Voros S, Nanda NC, Samal AK, Gomez CR, Puri VK, Jindal A, Terry JB, Tulyapronchote R, Thakur AC. Transesophageal Echocardiography Performed in Stroke Patients to Exclude Cardiac Sources of Embolism Accurately Detects Significant Proximal Coronary Artery Stenosis and Often Changes Management. American Heart Journal 2001;142:916-922.
Voros S, Kramer CM. Clinical applications of cardiovascular magnetic resonance imaging. Heartwise 2003;6(4):4-10.
Keser N, Nanda NC, Miller AP, Voros S, Soydas C, Agrawal G, Liguori C, Naftel D, Pacifico AD, Kirklin JK, McGiffin DC, Holman WL. Hemodynamic Evaluation of Normally Functioning Sulzer Carbomedics Prosthetic Valves. Ultrasound Med Biol. 2003 May;29(5):649-57.
Patel RAG, Dimarco JP, Akar JG, Voros S, Kramer CM. Chagas myocarditis and syncope. J Cardiovasc Magn Reson, 2005;7:685-688.
Voros S, Kramer CM. “Cardiovascular MRI: State of the Art” in Clinical Cardiology Reviews, (Bentham Science Publishers, London) 2005;1:181-188.
Szilard Voros MD, Zequan Yang MD, PhD, Christina M. Bove MD, Wesley D. Gilson PhD, Frederick H. Epstein PhD, Brent A. French, PhD, Stuart S. Berr PhD, Sanford P. Bishop PhD, DVM, Hiroaki Matsubara MD, PhD, Robert M. Carey MD, Christopher M. Kramer MD, FACC. The AT2 Receptor Mediates Most of the Benefit of AT1 Receptor Blockade During Post-Infarction Left Ventricular Remodeling. Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1004-10. Epub 2005 Oct 7.
Bove CM, DiMaria JM, Voros S, Conaway MR, Kramer CM. Dobutamine Response and Myocardial Infarct Transmurality: Functional Improvement after Coronary Artery Bypass Grafting—Initial Experience. Radiology 2006;240(3):835-842.
Akram K, Silverman ME, Voros S. A Unique Case of Pulmonary Artery Leiomyosarcoma. J Natl Med Assoc. 2006;98(12):1995-96.
Interaction Between Bradykinin Subtype 2 and Angiotensin II Type 2 Receptors During Post-MI Left Ventricular Remodeling. Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3372-8.
Schietinger BJ, Voros S, Isbell DC, Meyer CH, Christopher JM, Kramer CM. Can late gadolinium enhancement by cardiovascular magnetic resonance identify coronary artery disease as the etiology of new onset congestive heart failure? Int J Cardiovasc Imaging. 2007 Oct;23(5):595-602.
Kamran Akram, Szilard Voros. Absolute Coronary Artery Calcium Scores are superior to MESA percentile rank in predicting obstructive coronary artery disease. Int J Cardiovasc Imaging. 2008 Oct;24(7):743-9.
Szilard Voros. Can Computed Tomography Angiography of the Coronary Arteries Characterize Atherosclerotic Plaque Composition? Is the CAT (Scan) Out of the Bag? J. Am. Coll. Cardiol. Intv. 2008;1;183-185.
Kamran Akram, Robert E. O’Donnell, Spencer King, H. Robert Superko, Arthur Agatston, Szilard Voros. Influence of Symptomatic Status on the Prevalence of Obstructive Coronary Artery Disease in Patients with Zero Calcium Score. Atherosclerosis 2009;203:533–537.
Akram K, Voros S. Influence of symptoms and age on the predictive value of coronary artery calcium scanning. J Am Coll Cardiol. 2008 Dec 16;52(25):2214.
Akram K, Rinehart S, Voros S. Coronary arterial atherosclerotic plaque imaging by contrast-enhanced computed tomography: fantasy or reality? J Nucl Cardiol. 2008 Nov-Dec;15(6):818-29.
Voros S. What are the potential advantages and disadvantages of volumetric CT scanning? J Cardiovasc Comput Tomogr. 2009 Mar-Apr;3(2):67-70. Epub 2009 Jan 9.
Rinehart S, Vazquez G, Qian Z, Voros S. Coronary Plaque Imaging with Multi-Slice Computed Tomographic Angiography and Intravascular Ultrasound: A Close Look Inside and Out. J Inv Cardiol 2009; 21(7):367-372.
Qian Z, Marvasty I, Anderson H, Rinehart S, Voros S. Lesion-specific coronary artery calcium quantification better predicts cardiac events”. Proc. of IEEE International Symposium on Biomedical Imaging (ISBI), p237-240, 2009.
Akram K, Anderson HD, Voros S. Quantification of left ventricular parameters obtained by automated software for 64-slice multidetector computed tomography and comparison with magnetic resonance imaging. Cardiovasc Intervent Radiol. 2009 Nov;32(6):1154-60.
Voros S. "Does imaging paint a sugar-coated picture of diabetic vessels?" : plaque composition in diabetics by IVUS and CT angiography. J Nucl Cardiol. 2009 May-Jun;16(3):339-44. Epub 2009 Mar 10. No abstract available.
Voros S, Joshi PH, Vazquez G, Roth G, Murrieta L, Rinehart S, Qian Z, Miller J. Cardiovascular computed tomographic assessment of the effect of combination lipoprotein therapy on coronary arterial plaque: Rationale and design of the AFRICA (Atorvastatin plus Fenofibric acid in the Reduction of Intermediate Coronary Atherosclerosis) study. J Cardiovasc Comput Tomogr. 2010;4:164–172.
George Barbier, Jesus Gustavo Vazquez Figueroa, Sarah Rinehart, Zhen Qian, Parag Joshi, Charles Wilmer, Szilard Voros. Tissue Characterization of a Papillary Fibroelastoma on the Aortic Valve by Contrast-Enhanced 320-Detector Row Computed Tomography Accepted Manuscript, 7 June 2010. Journal of Cardiovascular Computed Tomography. DOI: 10.1016/j.jcct.2010.05.020
Zhen Qian, Hunt Anderson, Idean Marvasty, Kamran Akram, Gustavo Vazquez, Sarah Rinehart, Szilard Voros. Lesion- and Vessel-Specific Coronary Artery Calcium Scores are Superior to Whole-Heart Agatston and Volume Scores in the Diagnosis of Obstructive Coronary Artery Disease. Journal of Cardiovascular Computed Tomography. DOI: 10.1016/j.jcct.2010.09.001.
Sara Mobasseri, Szilard Voros. Clinical Trial Report: The Use of Coronary CT Angiography to Evaluate Chest Pain Patients—The ROMICAT (Rule Out Myocardial Infarction using Computer-Assisted Tomography) Study. Current Cardiovascular Imaging Reports. DOI: 10.1007/s12410-010-9051-7.
Rinehart S, Vazquez G, Qian Z, Murrieta L, Christian K, Voros S. Quantitative Measurements of Coronary Arterial Stenosis, Plaque Geometry and Composition are Highly Reproducible with a Standardized Coronary Arterial Computed Tomographic Approach in High-Quality CT Datasets. In Press. Journal of Cardiovascular Computed Tomography.
Rosenberg S, Elashoff MR, Beineke P, Daniels SE, Wingrove JA, Tingley WG, Sager PT, Sehnert AJ, Yau M, Kraus WE, Newby LK, Schwartz RS, Voros S, Ellis SG, Tahirkheli N, Waksman R, McPherson J, Lansky A, Winn ME, Schork NJ, Topol EJ. Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients. Ann Intern Med. 2010 Oct 5;153(7):425-34.
Prospective Validation of Standardized, 3-Dimensional, Quantitative Coronary Computed Tomographic Plaque Measurements Using Radiofrequency Backscatter Intravascular Ultrasound as Reference Standard in Intermediate Coronary Arterial Lesions Results From the ATLANTA (Assessment of Tissue Characteristics, Lesion Morphology, and Hemodynamics by Angiography With Fractional Flow Reserve, Intravascular Ultrasound and Virtual Histology, and Noninvasive Computed Tomography in Atherosclerotic Plaques) I Study.
Voros S, Rinehart S, Qian Z, Vazquez G, Anderson H, Murrieta L, Wilmer C, Carlson H, Taylor K, Ballard W, Karmpaliotis D, Kalynych A, Brown C 3rd. JACC Cardiovasc Interv. 2011 Feb;4(2):198-208. PMID: 21349459 [PubMed - in process].