TEL-JAK2
Encyclopedia
TEL
-JAK2 is a gene fusion
resulting from a chromosomal translocation
between chromosomes 9 and 12 observed in human leukemia
. The 5' moiety of TEL is fused to the 3' end of JAK2.
The oligomerisation
domain of the TEL protein (also called ETV6) becomes juxtaposed to the tyrosine
kinase
domain of JAK2, and as result the TEL-JAK2 displays constitutive kinase activity.
TEL
- Acronyms :TEL is a three-letter acronym for:* Tetra-ethyl lead, a gasoline additive to make leaded gasoline* Tokyo Electron, a semiconductor equipment manufacturer* Transporter erector launcher, a mobile missile launch platform...
-JAK2 is a gene fusion
Fusion gene
A fusion gene is a hybrid gene formed from two previously separate genes. It can occur as the result of a translocation, interstitial deletion, or chromosomal inversion...
resulting from a chromosomal translocation
Chromosomal translocation
In genetics, a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes. A gene fusion may be created when the translocation joins two otherwise separated genes, the occurrence of which is common in cancer. It is detected on...
between chromosomes 9 and 12 observed in human leukemia
Leukemia
Leukemia or leukaemia is a type of cancer of the blood or bone marrow characterized by an abnormal increase of immature white blood cells called "blasts". Leukemia is a broad term covering a spectrum of diseases...
. The 5' moiety of TEL is fused to the 3' end of JAK2.
The oligomerisation
Oligomer
In chemistry, an oligomer is a molecule that consists of a few monomer units , in contrast to a polymer that, at least in principle, consists of an unlimited number of monomers. Dimers, trimers, and tetramers are oligomers. Many oils are oligomeric, such as liquid paraffin...
domain of the TEL protein (also called ETV6) becomes juxtaposed to the tyrosine
Tyrosine kinase
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an "on" or "off" switch in many cellular functions....
kinase
Kinase
In chemistry and biochemistry, a kinase is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific substrates, a process referred to as phosphorylation. Kinases are part of the larger family of phosphotransferases...
domain of JAK2, and as result the TEL-JAK2 displays constitutive kinase activity.