TIA1
Encyclopedia
TIA1 is a poly(A)-binding protein
. It is associated with programmed cell death (apoptosis
) and regulates alternative splicing
of the gene encoding the Fas receptor
, an apoptosis-promoting protein.
Poly(A)-binding protein
Poly-binding protein is a RNA-binding protein which binds to the poly tail of mRNA. The poly tail is located on the 3' end of mRNA...
. It is associated with programmed cell death (apoptosis
Apoptosis
Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation...
) and regulates alternative splicing
Alternative splicing
Alternative splicing is a process by which the exons of the RNA produced by transcription of a gene are reconnected in multiple ways during RNA splicing...
of the gene encoding the Fas receptor
Fas receptor
The FAS receptor also known as apoptosis antigen 1 , cluster of differentiation 95 or tumor necrosis factor receptor superfamily member 6 is a protein that in humans is encoded by the TNFRSF6 gene....
, an apoptosis-promoting protein.