TRAF3
Encyclopedia
TNF receptor-associated factor 3 is a protein
that in humans is encoded by the TRAF3 gene
.
with CD30
, CD27
, Lymphotoxin beta receptor
, Nucleoporin 62
, CD40
, TNFSF14
, RANK
, Caspase 3
and TANK
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the TRAF3 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
TRAF3 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with CD30
CD30
CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker.This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the...
, CD27
CD27
CD27 is a tumor necrosis factor receptor.-Interactions:CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.-External links:...
, Lymphotoxin beta receptor
Lymphotoxin beta receptor
Lymphotoxin beta receptor is a receptor for lymphotoxin which in humans is encoded by the LTBR gene.-Function:The protein encoded by this gene is a member of the tumor necrosis factor family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid...
, Nucleoporin 62
Nucleoporin 62
Nucleoporin p62 is a protein complex associated with the nuclear envelope. The p62 protein remains associated with the nuclear pore complex-lamina fraction. p62 is synthesized as a soluble cytoplasmic precursor of 61 kDa followed by modification that involve addition of N-acetylglucosamine residues...
, CD40
CD40 (protein)
CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects....
, TNFSF14
TNFSF14
Tumor necrosis factor ligand superfamily member 14 is a protein that in humans is encoded by the TNFSF14 gene. TNFSF14 has also been designated as CD258, as well as LIGHT.-Interactions:...
, RANK
RANK
Receptor Activator of Nuclear Factor κ B , also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding...
, Caspase 3
Caspase 3
Caspase 3 is a caspase protein that interacts with caspase 8 and caspase 9. It is encoded by the CASP3 gene. CASP3 orthologs have been identified in numerous mammals for which complete genome data are available...
and TANK
TANK (gene)
TRAF family member-associated NF-kappa-B activator is a protein that in humans is encoded by the TANK gene.-Interactions:TANK has been shown to interact with TANK-binding kinase 1, IKBKE, TRAF2, IKBKG and TRAF3.-Further reading:...
.