TRIM45
Encyclopedia
tripartite motif containing 45, also known as TRIM45, is a human gene
.
This gene encodes a member of the tripartite motif family
. The encoded protein may function as a [transcriptional repressor of the mitogen-activated protein kinase
pathway. Alternatively spliced transcript variants have been described.
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
This gene encodes a member of the tripartite motif family
Tripartite motif family
-Function:Many TRIM proteins are induced by interferons, which are important component of resistance to pathogens and several TRIM proteins are known to be required for the restriction of infection by lentiviruses...
. The encoded protein may function as a [transcriptional repressor of the mitogen-activated protein kinase
Mitogen-activated protein kinase
Mitogen-activated protein kinases are serine/threonine-specific protein kinases that respond to extracellular stimuli and regulate various cellular activities, such as gene expression, mitosis, differentiation, proliferation, and cell survival/apoptosis.-Activation:MAP kinases are activated...
pathway. Alternatively spliced transcript variants have been described.