Tandem pore domain potassium channel

The two-pore-domain potassium channel is a family of 15 members form what is known as "leak channels" which possess Goldman-Hodgkin-Katz

GHK current equation

The Goldman–Hodgkin–Katz flux equation describes the ionic flux carried by an ionic species across a cell membrane as a function of the transmembrane potential and the concentrations of the ion inside and outside of the cell...

(open) rectification

Rectifier

A rectifier is an electrical device that converts alternating current , which periodically reverses direction, to direct current , which flows in only one direction. The process is known as rectification...

. These channels are regulated by several mechanisms including oxygen tension, pH

In chemistry, pH is a measure of the acidity or basicity of an aqueous solution. Pure water is said to be neutral, with a pH close to 7.0 at . Solutions with a pH less than 7 are said to be acidic and solutions with a pH greater than 7 are basic or alkaline...

, mechanical stretch, and G-proteins. Their name is derived from the fact that the α subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimer

Protein dimer

In biochemistry, a dimer is a macromolecular complex formed by two, usually non-covalently bound, macromolecules like proteins or nucleic acids...

s in the membrane.

Below is a list of the 15 known two-pore-domain human potassium channel

Potassium channel

In the field of cell biology, potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes...

Gene	Channel	Family	Aliases >- \|	K_2p1.1 KCNK1 Potassium channel subfamily K member 1 is a protein that in humans is encoded by the KCNK1 gene....	TWIK	>- \|	K_2p2.1 KCNK2 Potassium channel subfamily K member 2 is a protein that in humans is encoded by the KCNK2 gene.- External links :...	TREK	>- \|	K_2p3.1 KCNK3 Potassium channel subfamily K member 3 is a protein that in humans is encoded by the KCNK3 gene.-Interactions:KCNK3 has been shown to interact with YWHAB and S100A10.- External links :...	TASK	>- \|	K_2p4.1 KCNK4 Potassium channel subfamily K member 4 is a protein that in humans is encoded by the KCNK4 gene....	TREK	>- \|	K_2p5.1 KCNK5 Potassium channel subfamily K member 5 is a protein that in humans is encoded by the KCNK5 gene....	TASK	>- \|	K_2p6.1 KCNK6 Potassium channel subfamily K member 6 is a protein that in humans is encoded by the KCNK6 gene....	TWIK	>- \|	K_2p7.1 KCNK7 Potassium channel, subfamily K, member 7, also known as KCNK7 or K2P7.1 is a protein which in humans is encoded by the KCNK7 gene. K2P7.1 is a potassium channel containing two pore-forming P domains...	TWIK	>- \|	K_2p9.1 KCNK9 Potassium channel subfamily K member 9 is a protein that in humans is encoded by the KCNK9 gene.This gene encodes K2P9.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This open channel is highly expressed in the cerebellum...	TASK	>- \|	K_2p10.1 KCNK10 Potassium channel, subfamily K, member 10, also known as KCNK10 is a human gene. The protein encoded by this gene, K2P10.1, is a potassium channel containing two pore-forming P domains....	TREK	>- \|	K_2p12.1 KCNK12 Potassium channel, subfamily K, member 12, also known as KCNK12 is a human gene. The protein encoded by this gene, K2P12.1, is a potassium channel containing two pore-forming P domains....	THIK	>- \|	K_2p13.1 KCNK13 Potassium channel, subfamily K, member 13, also known as KCNK13 is a human gene. The protein encoded by this gene, K2P13.1 is a potassium channel containing two pore-forming P domains....	THIK	>- \|	K_2p15.1 KCNK15 Potassium channel subfamily K member 15 is a protein that in humans is encoded by the KCNK15 gene....	TASK	>- \|	K_2p16.1 KCNK16 Potassium channel subfamily K member 16 is a protein that in humans is encoded by the KCNK16 gene. The protein encoded by this gene, K2P16.1, is a potassium channel containing two pore-forming P domains....	TALK	>- \|	K_2p17.1 KCNK17 Potassium channel subfamily K member 17 is a protein that in humans is encoded by the KCNK17 gene....	TALK	>- \|	K_2p18.1 KCNK18 Potassium channel subfamily K member 18 , also known as TWIK-related spinal cord potassium channel or K2P18.1 is a protein that in humans is encoded by the KCNK18 gene. K2P18.1 is a potassium channel containing two pore-forming P domains.A flaw in this gene could help trigger migraine headaches...

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