The Neurosciences Institute
Encyclopedia
The Neurosciences Institute is a non-profit, scientific research organization dedicated to learning about the brain. Under the leadership of Nobel Laureate Gerald M. Edelman, M.D., Ph.D., the Institute focuses its theoretical and experimental work on the principles underlying how we perceive the world, how we learn and remember, and how consciousness arises.
The Neurosciences Institute (NSI) was founded in 1981 by Dr. Edelman in New York City
. In 1993 it moved to La Jolla, California
, and in 1995 into a newly designed headquarters in San Diego. The new building complex, which has received much acclaim for its architecture, was designed by Tod Williams Billie Tsien Architects
(previously Tod Williams Billie Tsien and Associates).
The Institute comprises a maximum of 40 Fellows
, and a small support staff to allow for an ideal level of dynamic interaction. Each Fellow works on a project of great interest or promise with the flexibility to modify direction as the project and results take shape. Many projects are so remarkable and cutting-edge that they would not be eligible for government funding, which is often limiting. All projects are centered on gaining a deeper understanding of the human brain. The entire operation is overseen by Dr. Edelman, who attends weekly focused group meetings and daily lunches and provides essential counsel for all research projects. Fellows are not required to obtain their own funding and non-restrictive institutional funding is pursued, along with flexible project-based funding.
The Institute began by sponsoring various activities for visiting scientists; these programs were generally organized at the suggestion of individual scientists around a focused research problem. Over the last two decades, more than 1,100 scientists from 300 institutes and 24 countries have visited the Institute to meet informally in small groups to exchange information, to plan experiments to be carried out upon return to their home institutions, or to prepare critical evaluations of current research for communication to the scientific community.
In 1988, the Institute began its own program of research in theoretical neurobiology. Carried out by a group of specially appointed resident Fellows, the program was designed to develop biologically based theories of higher brain functions and to train young scientists in the methods used to construct such neural theories.
In 1993, the Institute moved from New York to temporary quarters in La Jolla, California, while permanent facilities were being constructed nearby on land owned by The Scripps Research Institute. The new three-building complex, designed by the architecture firm Tod Williams Billie Tsien and Associates, has been awarded numerous honors, including the Honor Award for Architecture from the American Institute of Architects in 1997.
The complex includes experimental laboratories for research across a broad front of neurobiological disciplines, as well as facilities for theoretical research and for visiting scientists. With the laboratories complete, a research program for Fellows in Experimental Neurobiology was begun, thus fulfilling the original plan for the Institute’s full range of scientific activities
and Chairman of the Department of Neurobiology at that institution.
Dr. Edelman was born in New York City in 1929. He earned his B.S. degree at Ursinus College
and an M.D. at the University of Pennsylvania
. He spent a year at the Johnson Foundation of Medical Physics, and after a medical house officership at the Massachusetts General Hospital
, he served as a captain in the Army Medical Corps
. In 1960 he earned his Ph.D. at The Rockefeller University (previously Institute). In addition to the Nobel Prize
, Dr. Edelman has been the recipient of numerous awards and honors, including many honorary degrees. He is a member of the National Academy of Sciences
, the American Philosophical Society
, and several foreign societies, including the Academy of Sciences, Institute of France. He is author of over 500 publications.
Dr. Edelman has made significant research contributions in biophysics
, protein chemistry, immunology
, cell biology
, and neurobiology. His early studies on the structure and diversity of antibodies led to the Nobel Prize for Physiology or Medicine in 1972. His subsequent work led to the discovery of cell adhesion molecules (CAMs
) which have been found to guide the fundamental processes by which an animal achieves its shape and form, and by which nervous systems are built. One of the most significant insights provided by this work is that the precursor gene for the neural cell adhesion molecule also gave rise in evolution to the entire molecular system of adaptive immunity.
Dr. Edelman has formulated a detailed theory to explain the development and organization of higher brain functions in terms of a process known as neuronal group selection. This theory was presented in his 1987 volume Neural Darwinism, a widely known work. Dr. Edelman’s continuing work in theoretical neuroscience includes designing new kinds of machines, called recognition automata, that are capable of carrying out tests of the self-consistency of the theory of neuronal group selection and that promise to shed new light on the fundamental workings of the human brain. A new, biologically based theory of consciousness extending the theory of neuronal group selection is presented in his 1989 volume The Remembered Present. A subsequent book, Bright Air, Brilliant Fire, published in 1992, continues to explore the implications of neuronal group selection and neural evolution for a modern understanding of the mind and the brain. In his book Wider than the Sky: The Phenomenal Gift of Consciousness, Dr. Edelman offers an expanded model of the biology of consciousness. His latest book Second Nature: Brain Science and Human Knowledge explores the implication of this work for human understanding.
and Scripps Clinic to the west, The Burnham Institute to the north, the University of California, San Diego
to the south, and numerous biotechnology and pharmaceutical research companies to the east and in the immediate surrounding area.
When seeking an architect, Dr. Gerald Edelman sought a style that would reflect his vision of a scientific monastery where creative study of the brain could be conducted with few constraining rules and unlimited opportunities for discovery and communication. The Neurosciences Institute’s poetic architecture creates a physical environment that nurtures the Institute’s unique scientific sociology and adds to the effective exchanges between researchers in theoretical and experimental neuroscience. New York architects Tod Williams and Billie Tsien turned Edelman’s vision into an elegant reality with a design that for over a decade has nurtured scientific inquiry in an environment conducive to both private reflection and interactive exchange among scientists from different disciplines.
The campus is composed of three distinct buildings, each with its own fascinating design but all complementing and connecting with each other by walkways and a central plaza. The daily activities of the Institute are conducted in the Theory Center and the Walsh Family Laboratories. Theoretical and experimental research space, administrative support, and common areas are located in these buildings.
The Auditorium is designed to accommodate both scientific lectures and musical concerts. Noted acoustician Cyril Harris
worked with Tod Williams and Billie Tsien to create the 352-seat Auditorium. Considered to be among the most acoustically impressive small performance halls in the United States, the Auditorium has an original system of faceted, sound dispersing plaster panels that covers its walls and ceiling. Artists and audiences unequivocally confirm that the same sound is heard in every seat. As a community service, the Auditorium is made available without charge for use by select not-for-profit performing arts and educational organizations.
Under the leadership of Francis O. Schmitt
, a true scientific impresario, this informal college of scholars and research scientists was organized as the Neurosciences Research Program (NRP) at Massachusetts Institute of Technology
. Over the next two decades, and through over 250 meetings and 125 scientific publications, the NRP developed innovative formats for intellectual exchange and disseminated knowledge to the worldwide scientific community.
The central group, whose members are called Associates of the NRP, includes no more than 36 scientists at any one time, with each individual serving for a term of seven years before becoming an Honorary Associate. Over the past four decades, the list of current and Honorary Associates is a veritable “Who’s Who” of neuroscience and includes seventeen Nobel Laureates.
The Neurosciences Institute itself developed from the NRP as an independent institution on the campus of The Rockefeller University in New York in 1981. The NRP moved from Boston to New York in 1983 and became part of the Institute, when it moved to La Jolla in 1995. The Associates continue to meet annually at the Institute. Nothing shows the vibrancy of the neurosciences better than the NRP’s annual meeting. For three days, the Associates eagerly share their latest research, and guest speakers spark the imagination with presentations providing views of the brain and its functions. Informal discussions break out among Associates on far-flung topics.
The Neurosciences Institute (NSI) was founded in 1981 by Dr. Edelman in New York City
New York City
New York is the most populous city in the United States and the center of the New York Metropolitan Area, one of the most populous metropolitan areas in the world. New York exerts a significant impact upon global commerce, finance, media, art, fashion, research, technology, education, and...
. In 1993 it moved to La Jolla, California
California
California is a state located on the West Coast of the United States. It is by far the most populous U.S. state, and the third-largest by land area...
, and in 1995 into a newly designed headquarters in San Diego. The new building complex, which has received much acclaim for its architecture, was designed by Tod Williams Billie Tsien Architects
Tod Williams Billie Tsien Architects
Tod Williams Billie Tsien Architects are a husband-and-wife architectural firm founded in 1974, based in New York....
(previously Tod Williams Billie Tsien and Associates).
The Institute comprises a maximum of 40 Fellows
Fellows
Fellows or Fellowes is a surname and may refer to:People* Ailwyn Fellowes, 1st Baron Ailwyn , British businessman, farmer and politician* Carol Fellowes, 4th Baron Ailwyn , British peer...
, and a small support staff to allow for an ideal level of dynamic interaction. Each Fellow works on a project of great interest or promise with the flexibility to modify direction as the project and results take shape. Many projects are so remarkable and cutting-edge that they would not be eligible for government funding, which is often limiting. All projects are centered on gaining a deeper understanding of the human brain. The entire operation is overseen by Dr. Edelman, who attends weekly focused group meetings and daily lunches and provides essential counsel for all research projects. Fellows are not required to obtain their own funding and non-restrictive institutional funding is pursued, along with flexible project-based funding.
History
The Neurosciences Institute was established in 1981 and located as an independent entity on the campus of The Rockefeller University in New York City. It was founded in recognition that traditional barriers between disciplines had to be removed if fundamental brain functions were ever to be understood. It recognized the need for a different kind of scientific approach – one that emphasized formulation of scientific questions for future research, rather than only the assessment and dissemination of current knowledge.The Institute began by sponsoring various activities for visiting scientists; these programs were generally organized at the suggestion of individual scientists around a focused research problem. Over the last two decades, more than 1,100 scientists from 300 institutes and 24 countries have visited the Institute to meet informally in small groups to exchange information, to plan experiments to be carried out upon return to their home institutions, or to prepare critical evaluations of current research for communication to the scientific community.
In 1988, the Institute began its own program of research in theoretical neurobiology. Carried out by a group of specially appointed resident Fellows, the program was designed to develop biologically based theories of higher brain functions and to train young scientists in the methods used to construct such neural theories.
In 1993, the Institute moved from New York to temporary quarters in La Jolla, California, while permanent facilities were being constructed nearby on land owned by The Scripps Research Institute. The new three-building complex, designed by the architecture firm Tod Williams Billie Tsien and Associates, has been awarded numerous honors, including the Honor Award for Architecture from the American Institute of Architects in 1997.
The complex includes experimental laboratories for research across a broad front of neurobiological disciplines, as well as facilities for theoretical research and for visiting scientists. With the laboratories complete, a research program for Fellows in Experimental Neurobiology was begun, thus fulfilling the original plan for the Institute’s full range of scientific activities
Gerald Edelman
Gerald M. Edelman, M.D., Ph.D. is Director of The Neurosciences Institute and President of Neurosciences Research Foundation, Inc., the publicly supported not-for-profit organization that is the Institute’s parent. Separately, he is Professor at The Scripps Research InstituteThe Scripps Research Institute
The Scripps Research Institute is an American medical research facility that focuses on research in the basic biomedical sciences. Headquartered in La Jolla, California, with a sister facility in Jupiter, Florida, the institute is home to 3,000 scientists, technicians, graduate students, and...
and Chairman of the Department of Neurobiology at that institution.
Dr. Edelman was born in New York City in 1929. He earned his B.S. degree at Ursinus College
Ursinus College
Ursinus College is a liberal arts college in Collegeville, Montgomery County, Pennsylvania.-History:1867Members of the German Reformed Church begin plans to establish a college where "young men could be liberally educated under the benign influence of Christianity." These founders were hoping to...
and an M.D. at the University of Pennsylvania
University of Pennsylvania
The University of Pennsylvania is a private, Ivy League university located in Philadelphia, Pennsylvania, United States. Penn is the fourth-oldest institution of higher education in the United States,Penn is the fourth-oldest using the founding dates claimed by each institution...
. He spent a year at the Johnson Foundation of Medical Physics, and after a medical house officership at the Massachusetts General Hospital
Massachusetts General Hospital
Massachusetts General Hospital is a teaching hospital and biomedical research facility in the West End neighborhood of Boston, Massachusetts...
, he served as a captain in the Army Medical Corps
Medical Corps (United States Army)
The Medical Corps of the U.S. Army is a staff corps of the U.S. Army Medical Department consisting of commissioned medical officers – physicians with either an MD or a DO degree, at least one year of post-graduate clinical training, and a state medical license.The MC traces its earliest origins...
. In 1960 he earned his Ph.D. at The Rockefeller University (previously Institute). In addition to the Nobel Prize
Nobel Prize
The Nobel Prizes are annual international awards bestowed by Scandinavian committees in recognition of cultural and scientific advances. The will of the Swedish chemist Alfred Nobel, the inventor of dynamite, established the prizes in 1895...
, Dr. Edelman has been the recipient of numerous awards and honors, including many honorary degrees. He is a member of the National Academy of Sciences
United States National Academy of Sciences
The National Academy of Sciences is a corporation in the United States whose members serve pro bono as "advisers to the nation on science, engineering, and medicine." As a national academy, new members of the organization are elected annually by current members, based on their distinguished and...
, the American Philosophical Society
American Philosophical Society
The American Philosophical Society, founded in 1743, and located in Philadelphia, Pa., is an eminent scholarly organization of international reputation, that promotes useful knowledge in the sciences and humanities through excellence in scholarly research, professional meetings, publications,...
, and several foreign societies, including the Academy of Sciences, Institute of France. He is author of over 500 publications.
Dr. Edelman has made significant research contributions in biophysics
Biophysics
Biophysics is an interdisciplinary science that uses the methods of physical science to study biological systems. Studies included under the branches of biophysics span all levels of biological organization, from the molecular scale to whole organisms and ecosystems...
, protein chemistry, immunology
Immunology
Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with the physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders ; the...
, cell biology
Cell biology
Cell biology is a scientific discipline that studies cells – their physiological properties, their structure, the organelles they contain, interactions with their environment, their life cycle, division and death. This is done both on a microscopic and molecular level...
, and neurobiology. His early studies on the structure and diversity of antibodies led to the Nobel Prize for Physiology or Medicine in 1972. His subsequent work led to the discovery of cell adhesion molecules (CAMs
CAMS
CAMS can have the following meanings:* Centre for Advanced Media Studies, A premiere institute imparting education in the field of Film, Film Production and Media Technology....
) which have been found to guide the fundamental processes by which an animal achieves its shape and form, and by which nervous systems are built. One of the most significant insights provided by this work is that the precursor gene for the neural cell adhesion molecule also gave rise in evolution to the entire molecular system of adaptive immunity.
Dr. Edelman has formulated a detailed theory to explain the development and organization of higher brain functions in terms of a process known as neuronal group selection. This theory was presented in his 1987 volume Neural Darwinism, a widely known work. Dr. Edelman’s continuing work in theoretical neuroscience includes designing new kinds of machines, called recognition automata, that are capable of carrying out tests of the self-consistency of the theory of neuronal group selection and that promise to shed new light on the fundamental workings of the human brain. A new, biologically based theory of consciousness extending the theory of neuronal group selection is presented in his 1989 volume The Remembered Present. A subsequent book, Bright Air, Brilliant Fire, published in 1992, continues to explore the implications of neuronal group selection and neural evolution for a modern understanding of the mind and the brain. In his book Wider than the Sky: The Phenomenal Gift of Consciousness, Dr. Edelman offers an expanded model of the biology of consciousness. His latest book Second Nature: Brain Science and Human Knowledge explores the implication of this work for human understanding.
Architecture
The Neurosciences Institute campus is located on Torrey Pines Mesa in La Jolla, California, which emerged in the 1990s as one of the world’s leading centers for biomedical discovery. It is bordered by The Scripps Research InstituteThe Scripps Research Institute
The Scripps Research Institute is an American medical research facility that focuses on research in the basic biomedical sciences. Headquartered in La Jolla, California, with a sister facility in Jupiter, Florida, the institute is home to 3,000 scientists, technicians, graduate students, and...
and Scripps Clinic to the west, The Burnham Institute to the north, the University of California, San Diego
University of California, San Diego
The University of California, San Diego, commonly known as UCSD or UC San Diego, is a public research university located in the La Jolla neighborhood of San Diego, California, United States...
to the south, and numerous biotechnology and pharmaceutical research companies to the east and in the immediate surrounding area.
When seeking an architect, Dr. Gerald Edelman sought a style that would reflect his vision of a scientific monastery where creative study of the brain could be conducted with few constraining rules and unlimited opportunities for discovery and communication. The Neurosciences Institute’s poetic architecture creates a physical environment that nurtures the Institute’s unique scientific sociology and adds to the effective exchanges between researchers in theoretical and experimental neuroscience. New York architects Tod Williams and Billie Tsien turned Edelman’s vision into an elegant reality with a design that for over a decade has nurtured scientific inquiry in an environment conducive to both private reflection and interactive exchange among scientists from different disciplines.
The campus is composed of three distinct buildings, each with its own fascinating design but all complementing and connecting with each other by walkways and a central plaza. The daily activities of the Institute are conducted in the Theory Center and the Walsh Family Laboratories. Theoretical and experimental research space, administrative support, and common areas are located in these buildings.
The Auditorium is designed to accommodate both scientific lectures and musical concerts. Noted acoustician Cyril Harris
Cyril Harris
Cyril Kitchener Harris, , was Chief Rabbi of South Africa from 1987 to 2004....
worked with Tod Williams and Billie Tsien to create the 352-seat Auditorium. Considered to be among the most acoustically impressive small performance halls in the United States, the Auditorium has an original system of faceted, sound dispersing plaster panels that covers its walls and ceiling. Artists and audiences unequivocally confirm that the same sound is heard in every seat. As a community service, the Auditorium is made available without charge for use by select not-for-profit performing arts and educational organizations.
The Neurosciences Research Program (NRP)
In 1962, a small group of committed scientists from diverse backgrounds but with a common interest in brain function began to meet regularly to share ideas about how the brain works. Their driving motivation was the recognition that traditional barriers between practitioners of different scientific disciplines had to be broken if the goal of fully understanding the complexity of brain functions was ever to be reached.Under the leadership of Francis O. Schmitt
Francis O. Schmitt
Francis O. Schmitt was an American biologist and Institute Professor at the Massachusetts Institute of Technology.Schmitt received an A.B. in 1924 and a Ph.D. in 1927 from Washington University in St. Louis...
, a true scientific impresario, this informal college of scholars and research scientists was organized as the Neurosciences Research Program (NRP) at Massachusetts Institute of Technology
Massachusetts Institute of Technology
The Massachusetts Institute of Technology is a private research university located in Cambridge, Massachusetts. MIT has five schools and one college, containing a total of 32 academic departments, with a strong emphasis on scientific and technological education and research.Founded in 1861 in...
. Over the next two decades, and through over 250 meetings and 125 scientific publications, the NRP developed innovative formats for intellectual exchange and disseminated knowledge to the worldwide scientific community.
The central group, whose members are called Associates of the NRP, includes no more than 36 scientists at any one time, with each individual serving for a term of seven years before becoming an Honorary Associate. Over the past four decades, the list of current and Honorary Associates is a veritable “Who’s Who” of neuroscience and includes seventeen Nobel Laureates.
The Neurosciences Institute itself developed from the NRP as an independent institution on the campus of The Rockefeller University in New York in 1981. The NRP moved from Boston to New York in 1983 and became part of the Institute, when it moved to La Jolla in 1995. The Associates continue to meet annually at the Institute. Nothing shows the vibrancy of the neurosciences better than the NRP’s annual meeting. For three days, the Associates eagerly share their latest research, and guest speakers spark the imagination with presentations providing views of the brain and its functions. Informal discussions break out among Associates on far-flung topics.
Research programs
- Biological Bases of Consciousness
- Brain-Based-Devices (BBDs)
- Modeling Brain Systems
- Neural Basis of Decision Making
- Synapses and Neuronal Communication
- Genes, Drugs, and the Brain
- Genes and Behavior in Fruit Flies
- Sleep and Appetite in Fruit Flies
- Developmental Neurobiology
- Mitochondria
- Plasticity in the Auditory Cortex
- The Relationship of Music, Language and the Brain
- Rhythm and the Brain
- Temporal Dynamics of Brain Activity During Auditory Perception
- Neurological Diseases and Disorders