Thiazepine
Encyclopedia
Nitrogen
Nitrogen is a chemical element that has the symbol N, atomic number of 7 and atomic mass 14.00674 u. Elemental nitrogen is a colorless, odorless, tasteless, and mostly inert diatomic gas at standard conditions, constituting 78.08% by volume of Earth's atmosphere...
replacing a carbon
Carbon
Carbon is the chemical element with symbol C and atomic number 6. As a member of group 14 on the periodic table, it is nonmetallic and tetravalent—making four electrons available to form covalent chemical bonds...
in the seven-membered heterocyclic compound
Heterocyclic compound
A heterocyclic compound is a cyclic compound which has atoms of at least two different elements as members of its ring. The counterparts of heterocyclic compounds are homocyclic compounds, the rings of which are made of a single element....
.
Types include:
- 1,3-thiazepine1,3-Thiazepine1,3-thiazepine is a thiazepine....
- 1,4-thiazepine
Benzothiazepines (such as diltiazem
Diltiazem
Diltiazem is a non-dihydropyridine member of the class of drugs known as calcium channel blockers, used in the treatment of hypertension, angina pectoris, and some types of arrhythmia....
) have a single benzene
Benzene
Benzene is an organic chemical compound. It is composed of 6 carbon atoms in a ring, with 1 hydrogen atom attached to each carbon atom, with the molecular formula C6H6....
attached to the ring, while dibenzothiazepine
Dibenzothiazepine
Dibenzothiazepines are chemical compounds which are derivatives of thiazepine with two benzo rings.An example is quetiapine. Another is tianeptine....
s have two.
- Diltiazem, a benzothiazepine, is intermediate in properties between verapamilVerapamilVerapamil is an L-type calcium channel blocker of the phenylalkylamine class. It has been used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and most recently, cluster headaches. It is also an effective preventive medication for migraine...
and the dihydropyridines. - Diltiazem is used to treat variant angina (Prinzmetal's anginaPrinzmetal's anginaPrinzmetal angina, also known as variant angina or angina inversa, is a syndrome typically consisting of angina at rest that occurs in cycles...
), either naturally occurring or drug-induced and stable angina.