Timothy Ley
Encyclopedia
Timothy J Ley is an American hematologist, oncologist and cancer biologist. He is the Lewis T. and Rosalind B. Apple Professor of Oncology in the Department of Medicine, is chief of the Section of Stem Cell Biology in the Division of Oncology and is Professor of Genetics at Washington University in St. Louis
. He is an associate director of The Genome Institute at Washington University. Dr. Ley's research group has focused on the reference sequence of the human genome to systematically identify the mutations responsible for the initiation and progression of acute myeloid leukemia
(AML) and was part of the first group to fully sequence a cancer genome (of an AML patient). To better understand the role of these mutations, he and his colleagues have constructed several mouse models of acute promyelocytic leukemia
(APL), which are very similar to human APL. Dr. Ley's laboratory has also defined the roles of granzymes for the functions of cytotoxic and regulatory T cells.
Dr. Ley received his B.A. degree from Drake University
in 1974, and his M.D. from Washington University School of Medicine
in 1978. He did his internship and residency in Medicine at Massachusetts General Hospital
, was a Clinical Associate at the NHLBI (National Heart, Lung, and Blood Institute), a Hematology-Oncology Fellow at Washington University Medical Center, and a Senior Investigator at the NHLBI before moving to Washington University in 1986.
Washington University in St. Louis
Washington University in St. Louis is a private research university located in suburban St. Louis, Missouri. Founded in 1853, and named for George Washington, the university has students and faculty from all fifty U.S. states and more than 110 nations...
. He is an associate director of The Genome Institute at Washington University. Dr. Ley's research group has focused on the reference sequence of the human genome to systematically identify the mutations responsible for the initiation and progression of acute myeloid leukemia
Acute myeloid leukemia
Acute myeloid leukemia , also known as acute myelogenous leukemia, is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. AML is the most common acute...
(AML) and was part of the first group to fully sequence a cancer genome (of an AML patient). To better understand the role of these mutations, he and his colleagues have constructed several mouse models of acute promyelocytic leukemia
Acute promyelocytic leukemia
Acute promyelocytic leukemia is a subtype of acute myelogenous leukemia , a cancer of the blood and bone marrow. It is also known as acute progranulocytic leukemia; APL; AML with t, PML-RARA and variants; FAB subtype M3 and M3 variant.In APL, there is an abnormal accumulation of immature...
(APL), which are very similar to human APL. Dr. Ley's laboratory has also defined the roles of granzymes for the functions of cytotoxic and regulatory T cells.
Dr. Ley received his B.A. degree from Drake University
Drake University
Drake University is a private, co-educational university located in Des Moines, Iowa, USA. The institution offers a number of undergraduate and graduate programs, as well as professional programs in law and pharmacy. Today, Drake is one of the twenty-five oldest law schools in the country....
in 1974, and his M.D. from Washington University School of Medicine
Washington University School of Medicine
Washington University School of Medicine , located in St. Louis, Missouri, is one of the graduate schools of Washington University in St. Louis. One of the top medical schools in the United States, it is currently ranked 4th for research according to U.S. News and World Report and has been listed...
in 1978. He did his internship and residency in Medicine at Massachusetts General Hospital
Massachusetts General Hospital
Massachusetts General Hospital is a teaching hospital and biomedical research facility in the West End neighborhood of Boston, Massachusetts...
, was a Clinical Associate at the NHLBI (National Heart, Lung, and Blood Institute), a Hematology-Oncology Fellow at Washington University Medical Center, and a Senior Investigator at the NHLBI before moving to Washington University in 1986.
Awards and honors
- Member, Institute of MedicineInstitute of MedicineThe Institute of Medicine is a not-for-profit, non-governmental American organization founded in 1970, under the congressional charter of the National Academy of Sciences...
, 2003 - Fellow, American Academy of Arts and SciencesAmerican Academy of Arts and SciencesThe American Academy of Arts and Sciences is an independent policy research center that conducts multidisciplinary studies of complex and emerging problems. The Academy’s elected members are leaders in the academic disciplines, the arts, business, and public affairs.James Bowdoin, John Adams, and...
, 2010 - Fellow, American Association for the Advancement of ScienceAmerican Association for the Advancement of ScienceThe American Association for the Advancement of Science is an international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsibility, and supporting scientific education and science outreach for the...
, 2002 - President, American Society for Clinical InvestigationAmerican Society for Clinical InvestigationThe American Society for Clinical Investigation, or ASCI, established in 1908, is one of the nation's oldest and most respected medical honor societies.-Organization and Purpose:...
, 1997–1998 - Treasurer, Association of American PhysiciansAssociation of American PhysiciansThe Association of American Physicians is a medical society founded in 1885 by the Canadian physician Sir William Osler and six other distinguished physicians of his era, for "the advancement of scientific and practical medicine." Election to the AAP is an honor extended to individuals with...
, 2007–Present - Best Doctors In America
External links
- Genome Institute Bio
- Divisions of Hematology & Oncology Bio
- Washington University Physicians Bio
- PubMed Citations
- "Healthy Living: The Code Breakers." St. Louis Magazine. 2009 June.
- "Cancer gene complexity revealed." BBC News. 7 August 2009.