Toceranib
Encyclopedia
Toceranib is a receptor tyrosine kinase
inhibitor and is used in the treatment of canine mast cell
tumor also called mastocytoma
. Together with masitinib (Kinavet (US)/Masivet (EU/ROW) company: AB Science), Toceranib is the only dog-specific anti-cancer
drug approved by the U.S. Food and Drug Administration. It is marketed as Palladia as its phosphate salt, toceranib phosphate (INN
) by Pfizer
. It was developed by SUGEN
as SU11654 , a sister compound to SU11248, which was later approved for human therapies as Sutent. Toceranib is likely to act mostly through inhibition of the kit tyrosine kinase, though it may also have an anti-angiogenic
effect.
Receptor tyrosine kinase
Receptor tyrosine kinases s are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase proteins....
inhibitor and is used in the treatment of canine mast cell
Mast cell
A mast cell is a resident cell of several types of tissues and contains many granules rich in histamine and heparin...
tumor also called mastocytoma
Mastocytoma
A mastocytoma or mast cell tumor is a type of tumor consisting of mast cells. It is found in humans and many animal species; in human medicine it also can refer to an accumulation or nodule of mast cells that resembles a tumor....
. Together with masitinib (Kinavet (US)/Masivet (EU/ROW) company: AB Science), Toceranib is the only dog-specific anti-cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
drug approved by the U.S. Food and Drug Administration. It is marketed as Palladia as its phosphate salt, toceranib phosphate (INN
International Nonproprietary Name
An International Nonproprietary Name is the official nonproprietary or generic name given to a pharmaceutical substance, as designated by the World Health Organization...
) by Pfizer
Pfizer
Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...
. It was developed by SUGEN
SUGEN
SUGEN was a drug discovery company focused on development of protein kinase inhibitors. It was founded in 1991, and shut down in 2003, after pioneering protein kinases as therapeutic targets and developing the successful cancer therapy sunitinib .-Early history and focus:Sugen was founded in 1991...
as SU11654 , a sister compound to SU11248, which was later approved for human therapies as Sutent. Toceranib is likely to act mostly through inhibition of the kit tyrosine kinase, though it may also have an anti-angiogenic
Angiogenesis inhibitor
An angiogenesis inhibitor is a substance that inhibits the growth of new blood vessels . Some angiogenesis inhibitors are a normal part of the body's control, some are administered as drugs, and some come from diet....
effect.