Tolazamide
Encyclopedia
Tolazamide is an oral blood glucose lowering drug
used for people with Type 2 diabetes. It is part of the sulfonylurea family (ATC A10BB).
with ethyl chloroformate
in the presence of a base. Heating that intermediate with azepane
leads to the displacement of the ethoxy group and the formation of tolazemide:
Medication
A pharmaceutical drug, also referred to as medicine, medication or medicament, can be loosely defined as any chemical substance intended for use in the medical diagnosis, cure, treatment, or prevention of disease.- Classification :...
used for people with Type 2 diabetes. It is part of the sulfonylurea family (ATC A10BB).
Synthesis
para-Toluenesulfonamide is converted to its carbamateCarbamate
Carbamates are organic compounds derived from carbamic acid . A carbamate group, carbamate ester, and carbamic acids are functional groups that are inter-related structurally and often are interconverted chemically. Carbamate esters are also called urethanes.-Synthesis:Carbamic acids are derived...
with ethyl chloroformate
Ethyl chloroformate
Ethyl chloroformate is the ethyl ester of chloroformic acid. It is a reagent used in organic synthesis for the introduction of the ethyl carbamate protecting group and for the formation of carboxylic anhydrides....
in the presence of a base. Heating that intermediate with azepane
Azepane
Azepane is a saturated heterocycle, containing one nitrogen atom in seven-membered ring.A well known azepane derivative is caprolactam....
leads to the displacement of the ethoxy group and the formation of tolazemide: