Trypanocidal agent
Encyclopedia
A trypanocidal agent is an antiprotozoal agent
that acts upon on trypanosome
parasites.
Examples include:
Antiprotozoal agent
Antiprotozoal agents is a class of pharmaceuticals used in treatment of protozoan infection.Protozoans have little in common with each other and so agents effective against one pathogen may not be effective against another...
that acts upon on trypanosome
Trypanosoma
Trypanosoma is a genus of kinetoplastids , a monophyletic group of unicellular parasitic flagellate protozoa. The name is derived from the Greek trypano and soma because of their corkscrew-like motion. All trypanosomes are heteroxenous and are transmitted via a vector...
parasites.
Examples include:
- benzonidazole
- blasticidin SBlasticidin SBlasticidin S is an antibiotic that is produced by Streptomyces griseochromogenes. In biological research, specifically genetic engineering, it is used to select transformed cells which have been engineered to carry a resistance gene for blasticidin. In short, DNA of interest is fused to DNA...
- DAPIDAPIDAPI or 4',6-diamidino-2-phenylindole is a fluorescent stain that binds strongly to A-T rich regions in DNA. It is used extensively in fluorescence microscopy...
- diminazeneDiminazeneDiminazen is a di-amidine also known as 4,4'-bis. It binds DNA and RNA and is the acting component of diminazene aceturat drugs directed, e.g., against trypanosomiasis....
- diminazene aceturate
- eflornithineEflornithineEflornithine is a drug found to be effective in the treatment of facial hirsutism as well as in African trypanosomiasis...
- ethidium
- isometamidium chlorideIsometamidium chlorideIsometamidium chloride is a trypanocidal agent used in veterinary medicine....
- lonidamineLonidamineLonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the...
- melaminylthioarsenate
- melarsoprolMelarsoprolMelarsoprol is a medicinal drug used in the treatment of human African trypanosomiasis. It is also sold under the trade names “Mel B” and “Melarsen Oxide-BAL.”...
- nifurtimoxNifurtimoxNifurtimox is a 5-nitrofuran and is used to treat diseases caused by trypanosomes including Chagas disease and sleeping sickness. It is given by mouth and not by injection.-Indications:...
- pentamidinePentamidinePentamidine is an antimicrobial medication given for prevention and treatment of Pneumocystis pneumonia caused by Pneumocystis jirovecii , a severe interstitial type of pneumonia often seen in patients with HIV infection...
- posaconazolePosaconazolePosaconazole is a triazole antifungal drug.Posaconazole is marketed in the United States, the European Union, and in other countries by Schering-Plough under the trade name Noxafil...
- puromycinPuromycinPuromycin is an antibiotic that is a protein synthesis inhibitor by inhibiting translation.-Inhibition of translation:Puromycin is an aminonucleoside antibiotic, derived from the Streptomyces alboniger bacterium, that causes premature chain termination during translation taking place in the...
- quinapyramineQuinapyramineQuinapyramine is a trypanocidal agent for veterinary use....
- salicylhydroxamic acidSalicylhydroxamic acidSalicylhydroxamic acid is a drug that is a potent and irreversible inhibitor of bacterial and plant urease usually used for urinary tract infections. The molecule is similar to urea but is not hydrolyzable by the urease enzyme. It is also a trypanocidal agent...
- suraminSuraminSuramin is a drug developed by Oskar Dressel and Richard Kothe of Bayer, Germany in 1916, and is still sold by Bayer under the brand name Germanin.According to the National Cancer Institute there are no active clinical trials...
- tetraphenylporphine sulfonateTetraphenylporphine sulfonateTetraphenylporphine sulfonate is a trypanocidal agent....