Turnip crinkle virus (TCV) repressor of minus strand synthesis H5

The TCV hairpin 5 is an RNA element

Cis-regulatory element

A cis-regulatory element or cis-element is a region of DNA or RNA that regulates the expression of genes located on that same molecule of DNA . This term is constructed from the Latin word cis, which means "on the same side as". These cis-regulatory elements are often binding sites for one or...

found in the turnip crinkle virus

Turnip crinkle virus

Turnip crinkle virus is a plant pathogenic virus of the family Tombusviridae.TCV is a small , icosohedral, single stranded, positive sense RNA virus . It has been shown to infect various types of plant species including the common plant model, Arabidopsis thaliana, and is currently being studied...

. This RNA element is composed of a stem-loop

Stem-loop

Stem-loop intramolecular base pairing is a pattern that can occur in single-stranded DNA or, more commonly, in RNA. The structure is also known as a hairpin or hairpin loop. It occurs when two regions of the same strand, usually complementary in nucleotide sequence when read in opposite directions,...

that contains a large symmetrical internal loop (LSL). H5 can repress minus-strand synthesis when the 3' side of the LSL pairs

Base pair

In molecular biology and genetics, the linking between two nitrogenous bases on opposite complementary DNA or certain types of RNA strands that are connected via hydrogen bonds is called a base pair...

with the 4 bases

Nucleotide

Nucleotides are molecules that, when joined together, make up the structural units of RNA and DNA. In addition, nucleotides participate in cellular signaling , and are incorporated into important cofactors of enzymatic reactions...

at the 3'-terminus of the RNA(GCCC-OH).

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