U.S. Route 19 is a north–south U.S. Highway. Despite encroaching Interstate Highways, the route has remained a long-haul route, connecting the Gulf of Mexico

Gulf of Mexico

The Gulf of Mexico is a partially landlocked ocean basin largely surrounded by the North American continent and the island of Cuba. It is bounded on the northeast, north and northwest by the Gulf Coast of the United States, on the southwest and south by Mexico, and on the southeast by Cuba. In...

 with Lake Erie

Lake Erie

Lake Erie is the fourth largest lake of the five Great Lakes in North America, and the tenth largest globally. It is the southernmost, shallowest, and smallest by volume of the Great Lakes and therefore also has the shortest average water residence time. It is bounded on the north by the...

.

The highway's southern terminus is at Memphis, Florida

Memphis, Florida

Memphis is a census-designated place in Manatee County, Florida, United States. The population was 7,264 at the 2000 census. It is part of the Bradenton–Sarasota–Venice Metropolitan Statistical Area.-Geography:...

, just north of Bradenton, Florida at an intersection with U.S. Route 41

U.S. Route 41

U.S. Route 41 is a north–south United States Highway that runs from Miami, Florida to the Upper Peninsula of Michigan. Until 1949, the part in southern Florida, from Naples to Miami, was U.S...

. It's northern terminus is in Erie, Pennsylvania

Erie, Pennsylvania

Erie is a city located in northwestern Pennsylvania in the United States. Named for the lake and the Native American tribe that resided along its southern shore, Erie is the state's fourth-largest city , with a population of 102,000...

, at an intersection with U.S. Route 20

U.S. Route 20

U.S. Route 20 is an east–west United States highway. As the "0" in its route number implies, US 20 is a coast-to-coast route. Spanning , it is the longest road in the United States, and the route sparsely parallels Interstate 90...

 about two miles (3 km) from the shores of Lake Erie

Lake Erie

Lake Erie is the fourth largest lake of the five Great Lakes in North America, and the tenth largest globally. It is the southernmost, shallowest, and smallest by volume of the Great Lakes and therefore also has the shortest average water residence time. It is bounded on the north by the...

.

The length of the highway is 1377 miles (2,216.1 km) following the U.S.