URB754
Encyclopedia
URB754 was originally reported to be a potent, noncompetitive inhibitor of monoacylglycerol lipase
. However, recent studies have shown that URB754 failed to inhibit recombinant MGL, and brain FAAH
activity was also resistant to URB754. Some controversy in the field remains regarding the use of this compound.
Monoacylglycerol lipase
Monoacylglycerol lipase, also known as MAG lipase, MAGL, MGL or MGLL is a protein that, in humans, is encoded by the MGLL gene. MAGL is a 33-kDa, membrane-associated member of the serine hydrolase superfamily and contains the classical GXSXG consensus sequence common to most serine hydrolases...
. However, recent studies have shown that URB754 failed to inhibit recombinant MGL, and brain FAAH
FAAH
Fatty acid amide hydrolase or FAAH is a member of the serine hydrolase family of enzymes. It was first shown to breakdown anandamide in 1993 . In humans, it is encoded by the gene FAAH.-Function:...
activity was also resistant to URB754. Some controversy in the field remains regarding the use of this compound.