USS Yorktown may refer to one of many real-world or fictional vessels:

In the United States Navy:, a 16-gun sloop-of-war commissioned in 1840 (sunk in 1850), the lead Yorktown-class gunboat commissioned in 1889 (sold in 1921), the lead Yorktown-class aircraft carrier commissioned in 1937 (sunk in 1942), an Essex-class aircraft carrier commissioned in 1943 (museum ship since 1975), a Ticonderoga-class cruiser commissioned in 1984 (awaiting scrapping)

In fiction:

• At least two USS Yorktowns have appeared in the Star Trek franchise:
  • USS Yorktown, a Constitution-class starship appearing in the 23rd century
  • USS Yorktown (NCC-61137), a Zodiac-class starship appearing in the 24th century