Undruggable protein
Encyclopedia
Difficult targets
Undruggable proteins are hard for pharmaceutical researchers to target, as they do not have suitable loci that bind to small organic molecules. For instance, proteins responsible for pancreatic cancerPancreatic cancer
Pancreatic cancer refers to a malignant neoplasm of the pancreas. The most common type of pancreatic cancer, accounting for 95% of these tumors is adenocarcinoma, which arises within the exocrine component of the pancreas. A minority arises from the islet cells and is classified as a...
are undruggable.