Vedolizumab
Encyclopedia
Vedolizumab is a monoclonal antibody
being developed by Millennium Pharmaceuticals
, Inc. for the treatment of ulcerative colitis
and Crohn's disease
. It binds to integrin
α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1)
, vedolizumab is undergoing Phase III trials.
Monoclonal antibodies
Monoclonal antibodies are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a unique parent cell....
being developed by Millennium Pharmaceuticals
Millennium Pharmaceuticals
Millennium Pharmaceuticals, Inc., The Takeda Oncology Company is a biopharmaceutical company based in Cambridge, Massachusetts. The Company markets Velcade for injection, a cancer product, and has a growing clinical development pipeline of product candidates...
, Inc. for the treatment of ulcerative colitis
Ulcerative colitis
Ulcerative colitis is a form of inflammatory bowel disease . Ulcerative colitis is a form of colitis, a disease of the colon , that includes characteristic ulcers, or open sores. The main symptom of active disease is usually constant diarrhea mixed with blood, of gradual onset...
and Crohn's disease
Crohn's disease
Crohn's disease, also known as regional enteritis, is a type of inflammatory bowel disease that may affect any part of the gastrointestinal tract from mouth to anus, causing a wide variety of symptoms...
. It binds to integrin
Integrin
Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the ECM. They also play a role in cell signaling and thereby regulate cellular shape, motility, and the cell cycle....
α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1)
, vedolizumab is undergoing Phase III trials.