Venule
Encyclopedia
A venule is a very small blood vessel
in the microcirculation
that allows deoxygenated blood
to return from the capillary
beds to the larger blood vessels called vein
s. Venules range from 8 to 100μm in diameter and are formed when capillaries unite (come together).
Venules are blood vessels that drain blood directly from the capillary beds. Many venules unite to form a vein.
composed of squamous endothelial cell
s that act as a membrane
, a middle layer of muscle and elastic tissue and an outer layer of fibrous connective tissue. The middle layer is poorly developed so that venules have thinner walls than arterioles. They are extremely porous so that fluid and blood cells can move easily from the bloodstream through their walls.
In contrast to regular venules, high endothelial venules
are a special type of venule where the endothelium is made up of simple cuboidal cells. Lymphocytes re-enter the bloodstream through the HEVs.
They form from anastomosis of capillaries, using the beta form of semi-red blood cells and white blood cells to form.
Blood vessel
The blood vessels are the part of the circulatory system that transports blood throughout the body. There are three major types of blood vessels: the arteries, which carry the blood away from the heart; the capillaries, which enable the actual exchange of water and chemicals between the blood and...
in the microcirculation
Microcirculation
The microcirculation is a term used to describe the small vessels in the vasculature which are embedded within organs and are responsible for the distribution of blood within tissues; as opposed to larger vessels in the macrocirculation which transport blood to and from the organs...
that allows deoxygenated blood
Blood
Blood is a specialized bodily fluid in animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells....
to return from the capillary
Capillary
Capillaries are the smallest of a body's blood vessels and are parts of the microcirculation. They are only 1 cell thick. These microvessels, measuring 5-10 μm in diameter, connect arterioles and venules, and enable the exchange of water, oxygen, carbon dioxide, and many other nutrient and waste...
beds to the larger blood vessels called vein
Vein
In the circulatory system, veins are blood vessels that carry blood towards the heart. Most veins carry deoxygenated blood from the tissues back to the heart; exceptions are the pulmonary and umbilical veins, both of which carry oxygenated blood to the heart...
s. Venules range from 8 to 100μm in diameter and are formed when capillaries unite (come together).
Venules are blood vessels that drain blood directly from the capillary beds. Many venules unite to form a vein.
Structure
Venule walls have three layers: An inner endotheliumEndothelium
The endothelium is the thin layer of cells that lines the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall. These cells are called endothelial cells. Endothelial cells line the entire circulatory system, from the heart...
composed of squamous endothelial cell
Endothelium
The endothelium is the thin layer of cells that lines the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall. These cells are called endothelial cells. Endothelial cells line the entire circulatory system, from the heart...
s that act as a membrane
Biological membrane
A biological membrane or biomembrane is an enclosing or separatingmembrane that acts as a selective barrier, within or around a cell. It consists of a lipid bilayer with embedded proteins that may constitute close to 50% of membrane content...
, a middle layer of muscle and elastic tissue and an outer layer of fibrous connective tissue. The middle layer is poorly developed so that venules have thinner walls than arterioles. They are extremely porous so that fluid and blood cells can move easily from the bloodstream through their walls.
In contrast to regular venules, high endothelial venules
High endothelial venules
High endothelial venules are specialized post-capillary venous swellings characterized by plump endothelial cells as opposed to the usual thiner endothelial cells found in regular venules...
are a special type of venule where the endothelium is made up of simple cuboidal cells. Lymphocytes re-enter the bloodstream through the HEVs.
They form from anastomosis of capillaries, using the beta form of semi-red blood cells and white blood cells to form.