Verrucous carcinoma
Encyclopedia
Verrucous carcinoma is an uncommon variant of squamous cell carcinoma
. This form of cancer is often seen in those who chew tobacco
or use snuff
orally, so much so that it is sometimes referred to as "Snuff dipper's cancer."
Most patients with verrucous carcinoma have a good prognosis. Local recurrence is not uncommon, but metastasis
to distant parts of the body is rare. Patients with oral verrucous carcinoma may be at greater risk of a second oral squamous cell carcinoma, for which the prognosis is worse.
It is also known as an Ackerman tumor.
Squamous cell carcinoma
Squamous cell carcinoma , occasionally rendered as "squamous-cell carcinoma", is a histologically distinct form of cancer. It arises from the uncontrolled multiplication of malignant cells deriving from epithelium, or showing particular cytological or tissue architectural characteristics of...
. This form of cancer is often seen in those who chew tobacco
Tobacco
Tobacco is an agricultural product processed from the leaves of plants in the genus Nicotiana. It can be consumed, used as a pesticide and, in the form of nicotine tartrate, used in some medicines...
or use snuff
Snuff
Snuff is a product made from ground or pulverised tobacco leaves. It is an example of smokeless tobacco. It originated in the Americas and was in common use in Europe by the 17th century...
orally, so much so that it is sometimes referred to as "Snuff dipper's cancer."
Most patients with verrucous carcinoma have a good prognosis. Local recurrence is not uncommon, but metastasis
Metastasis
Metastasis, or metastatic disease , is the spread of a disease from one organ or part to another non-adjacent organ or part. It was previously thought that only malignant tumor cells and infections have the capacity to metastasize; however, this is being reconsidered due to new research...
to distant parts of the body is rare. Patients with oral verrucous carcinoma may be at greater risk of a second oral squamous cell carcinoma, for which the prognosis is worse.
Classification
Verrucous carcinoma may be divided into the following four types:- Type I, also known as Oral florid papillomatosisOral florid papillomatosisOral florid papillomatosis is a condition characterized by a white mass resembling a cauliflower covering the tongue and extending onto other portions of the mucous membranes. This is a type of verrucous carcinoma.- See also :* Mucous membrane...
- Type II, also known as Anogential type verrucous carcinoma
- Type III, also known as Epithelioma cuniculatum
- Type IV
Definition
It’s a diffuse, papillary, non metastasizing, well differentiated, malignant neoplasm of epidermis or oral epithelium.It is also known as an Ackerman tumor.
Etiology
This form of cancer is often seen in those who chew tobacco or use snuff orally, so much so that it is sometimes referred to as "Snuff dipper's cancer."Clinical features
- age- usually over 60 yrs
- sex- males are more prone
- site- gingiva, buccal mucosa, alveolar mucosa, hard palate, floor of the mouth, larynx, oesophagus, penis, vagina, scrotum.
- clinical presentation-
- It’s a slow growing, diffuse, exophytic lesion usually covered by Leukoplakik patches.
- Invasive lesions quickly invade bones
- It is rapidly become fixed with underlying periosteum and cause gradual destruction of jaw bone.
- Enlarged regional lymph nodes
- Lesion shows painful multiple rugae like folds and deep clefts between them.
See also
- Giant condyloma acuminatumGiant condyloma acuminatumGiant condyloma acuminatum is a rare cutaneous condition characterized by an aggressive, wart-like growth that is a verrucous carcinoma. It is attributed to human papillomavirus....
- Squamous cell carcinomaSquamous cell carcinomaSquamous cell carcinoma , occasionally rendered as "squamous-cell carcinoma", is a histologically distinct form of cancer. It arises from the uncontrolled multiplication of malignant cells deriving from epithelium, or showing particular cytological or tissue architectural characteristics of...
- List of cutaneous conditions