Vinca alkaloids are a set of anti-mitotic and anti-microtubule agents which were originally derived from the Periwinkle plant

Catharanthus roseus

Catharanthus roseus is a species of Catharanthus native and endemic to Madagascar. Synonyms include Vinca rosea , Ammocallis rosea, and Lochnera rosea; other English names occasionally used include Cape Periwinkle, Rose Periwinkle, Rosy Periwinkle, and "Old-maid".In the wild, it is an endangered...

 Catharanthus roseus.

Vinca alkaloids are used in the treatment of cancer. They are a class of cell-cycle-specific cytotoxic drugs which work by inhibiting the ability of cancer cells to divide: acting upon tubulin, they prevent it from forming into microtubules, a necessary component for cellular division.
Vinca alkaloids are now produced synthetically and used as drugs in cancer therapy and as immunosuppressive drugs. These compounds include vinblastine

Vinblastine

Vinblastine is an antimicrotubule drug used to treat certain kinds of cancer, including Hodgkin's lymphoma, non-small cell lung cancer, breast cancer, head and neck cancer, and testicular cancer. It is also used to treat Langerhan cell histiocytosis....

, vincristine

Vincristine

Vincristine , formally known as leurocristine, sometimes abbreviated "VCR", is a vinca alkaloid from the Catharanthus roseus , formerly Vinca rosea and hence its name. It is a mitotic inhibitor, and is used in cancer chemotherapy.-Mechanism:Tubulin is a structural protein that polymerizes to...

, vindesine

Vindesine

Vindesine is an anti-mitotic vinca alkaloid used in chemotherapy. It is used to treat many different types of cancer, including leukaemia, lymphoma, melanoma, breast cancer, and lung cancer....

 and vinorelbine

Vinorelbine

Vinorelbine is an anti-mitotic chemotherapy drug that is given as a treatment for some types of cancer, including breast cancer and non-small cell lung cancer.-Pharmacology:...

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