Warty dyskeratoma
Encyclopedia
Warty dyskeratoma, also known as an Isolated dyskeratosis follicularis,) is a benign
epidermal proliferation with distinctive histologic findings that may mimic invasive squamous cell carcinoma and commonly manifests as an umbilicated (Having a central mark or depression resembling a navel
) lesion with a keratotic plug, WD have some histopathologic similarities to viral warts but its not caused by HPV and the majority of these lesions display overall histopathologic features consistent with a follicular adnexal neoplasm. usually limited to the head
, neck
, scalp
or face
and vulva
. Lesions are generally solitary and sporadic and may be associated with a follicular unit. Oral
involvement, particularly the hard palate
, and genital involvement have been reported. it can also be thought of as one of the manifestations of focal acantholytic dyskeratosis
, an epidermal reaction pattern that can be seen in several disorders, including Darier's disease
and Grover's disease
. But the main Difference between Darier disease and Warty dyskeratoma, is that Darier disease inherited dermatosis (autosomal dominant) consisting of multiple keratotic papules on the face
, trunk
, and extremities
, while WD occurs as an isolated, noninherited, single keratotic nodule mainly confined to the head
and neck
as mentioned earlier.
, squamous carcinoma, condyloma
, and other viral-induced squamous lesions.
Benign
A benign tumor is a tumor that lacks the ability to metastasize. Common examples of benign tumors include moles and uterine fibroids.The term "benign" implies a mild and nonprogressive disease. Indeed, many kinds of benign tumors are harmless to human health...
epidermal proliferation with distinctive histologic findings that may mimic invasive squamous cell carcinoma and commonly manifests as an umbilicated (Having a central mark or depression resembling a navel
Navel
The navel is a scar on the abdomen caused when the umbilical cord is removed from a newborn baby...
) lesion with a keratotic plug, WD have some histopathologic similarities to viral warts but its not caused by HPV and the majority of these lesions display overall histopathologic features consistent with a follicular adnexal neoplasm. usually limited to the head
Head
In anatomy, the head of an animal is the rostral part that usually comprises the brain, eyes, ears, nose and mouth . Some very simple animals may not have a head, but many bilaterally symmetric forms do....
, neck
Neck
The neck is the part of the body, on many terrestrial or secondarily aquatic vertebrates, that distinguishes the head from the torso or trunk. The adjective signifying "of the neck" is cervical .-Boner anatomy: The cervical spine:The cervical portion of the human spine comprises seven boney...
, scalp
Scalp
The scalp is the anatomical area bordered by the face anteriorly and the neck to the sides and posteriorly.-Layers:It is usually described as having five layers, which can conveniently be remembered as a mnemonic:...
or face
Face
The face is a central sense organ complex, for those animals that have one, normally on the ventral surface of the head, and can, depending on the definition in the human case, include the hair, forehead, eyebrow, eyelashes, eyes, nose, ears, cheeks, mouth, lips, philtrum, temple, teeth, skin, and...
and vulva
Vulva
The vulva consists of the external genital organs of the female mammal. This article deals with the vulva of the human being, although the structures are similar for other mammals....
. Lesions are generally solitary and sporadic and may be associated with a follicular unit. Oral
Mouth
The mouth is the first portion of the alimentary canal that receives food andsaliva. The oral mucosa is the mucous membrane epithelium lining the inside of the mouth....
involvement, particularly the hard palate
Hard palate
The hard palate is a thin horizontal bony plate of the skull, located in the roof of the mouth. It spans the arch formed by the upper teeth.It is formed by the palatine process of the maxilla and horizontal plate of palatine bone....
, and genital involvement have been reported. it can also be thought of as one of the manifestations of focal acantholytic dyskeratosis
Dyskeratosis
Dyskeratosis it is abnormal keratinization occurring prematurely within individual cells or groups of cells below the stratum corneum....
, an epidermal reaction pattern that can be seen in several disorders, including Darier's disease
Darier's disease
Darier's disease , also known as Darier disease, Darier–White disease, Dyskeratosis follicularis and Keratosis follicularis, is an autosomal dominant disorder discovered by French dermatologist Ferdinand-Jean Darier. Darier's is characterized by dark crusty patches on the skin, sometimes containing...
and Grover's disease
Grover's disease
Grover's disease is a polymorphic, pruritic, papulovesicular dermatosis characterized histologically by acantholysis....
. But the main Difference between Darier disease and Warty dyskeratoma, is that Darier disease inherited dermatosis (autosomal dominant) consisting of multiple keratotic papules on the face
Face
The face is a central sense organ complex, for those animals that have one, normally on the ventral surface of the head, and can, depending on the definition in the human case, include the hair, forehead, eyebrow, eyelashes, eyes, nose, ears, cheeks, mouth, lips, philtrum, temple, teeth, skin, and...
, trunk
Torso
Trunk or torso is an anatomical term for the central part of the many animal bodies from which extend the neck and limbs. The trunk includes the thorax and abdomen.-Major organs:...
, and extremities
Limb (anatomy)
A limb is a jointed, or prehensile , appendage of the human or other animal body....
, while WD occurs as an isolated, noninherited, single keratotic nodule mainly confined to the head
Head
In anatomy, the head of an animal is the rostral part that usually comprises the brain, eyes, ears, nose and mouth . Some very simple animals may not have a head, but many bilaterally symmetric forms do....
and neck
Neck
The neck is the part of the body, on many terrestrial or secondarily aquatic vertebrates, that distinguishes the head from the torso or trunk. The adjective signifying "of the neck" is cervical .-Boner anatomy: The cervical spine:The cervical portion of the human spine comprises seven boney...
as mentioned earlier.
Differential Diagnosis
Warty dyskeratoma must be differentiated from vulvar dysplasia, bowenoid papulosisBowenoid papulosis
Bowenoid papulosis is a cutaneous condition characterized by the presence of pigmented verrucous papules on the body of the penis. They are associated with human papillomavirus, the causative agent of genital warts...
, squamous carcinoma, condyloma
Condyloma
Condyloma refers to an infection of the genitals. The two subtypes are:* Condyloma acuminata, or genital warts, caused by human papilloma virus subtypes 6, 11, and others...
, and other viral-induced squamous lesions.
See also
- Keratosis follicularisKeratosis follicularisKeratosis follicularis may refer to:* Darier's disease* Focal palmoplantar keratoderma with oral mucosal hyperkeratosisSee also:* Isolated dyskeratosis follicularis* Keratosis follicularis spinulosa decalvans...
- Stucco keratosisStucco keratosisStucco keratosis is a common benign cutaneous condition characterized by a skin lesion with a dull or lackluster surface, and with church-spire-like projections of epidermal cells around collagen seen histologically....
- List of cutaneous conditions