XRCC1
Encyclopedia
XRCC1 is a DNA repair
protein
.
It complexes with DNA ligase
III.
with PARP2
, DNA polymerase beta
, Aprataxin
, Oxoguanine glycosylase
, PCNA
, APEX1
, PNKP
and PARP1
.
DNA repair
DNA repair refers to a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as UV light and radiation can cause DNA damage, resulting in as many as 1...
protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
.
It complexes with DNA ligase
DNA ligase
In molecular biology, DNA ligase is a specific type of enzyme, a ligase, that repairs single-stranded discontinuities in double stranded DNA molecules, in simple words strands that have double-strand break . Purified DNA ligase is used in gene cloning to join DNA molecules together...
III.
Interactions
XRCC1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with PARP2
PARP2
Poly [ADP-ribose] polymerase 2 is an enzyme that in humans is encoded by the PARP2 gene.-Further reading:...
, DNA polymerase beta
DNA polymerase beta
[edit]Polymerase , beta, also known as POLB, is an enzyme that, in humans, is encoded by the POLB gene.- Function :...
, Aprataxin
Aprataxin
Aprataxin is a protein that in humans is encoded by the APTX gene.-Interactions:Aprataxin has been shown to interact with XRCC1, PARP1 and P53.-External links:**...
, Oxoguanine glycosylase
Oxoguanine glycosylase
8-Oxoguanine glycosylase also known as OGG1 is a DNA glycosylase enzyme that, in humans, is encoded by the OGG1 gene. It is involved in base excision repair.- Function :...
, PCNA
PCNA
Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase δ in eukaryotic cells. It achieves this processivity by encircling the DNA, thus creating a topological link to the genome...
, APEX1
APEX1
DNA- lyase is an enzyme that in humans is encoded by the APEX1 gene.-Interactions:APEX1 has been shown to interact with MUTYH, Flap structure-specific endonuclease 1 and XRCC1.-Further reading:...
, PNKP
PNKP
Bifunctional polynucleotide phosphatase/kinase is an enzyme that in humans is encoded by the PNKP gene.-Interactions:PNKP has been shown to interact with DNA polymerase beta and XRCC1.-Further reading:...
and PARP1
PARP1
Poly [ADP-ribose] polymerase 1 also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene.- Function :PARP1 works:...
.