ZD6126
Encyclopedia
ZD6126 is a vascular-targeting agent
and a prodrug
of N-acetylcolchinol, related to colchicine
. It has shown promising results on tumor
s in mice.
A phase I clinical trial
identified gastrointestinal and cardiac effects as limiting dosing. Two phase II
clinical trial
s were started investigating ZD6126 in metastatic renal cell carcinoma and metastatic colorectal cancer.
ZD6126 was being investigated by AstraZeneca as a vascular disrupting agent (VDA). However, the trials were halted, after it became apparent that ZD6126 was too cardiotoxic at the required doses.
Vascular-targeting agent
A vascular-targeting agent or vascular disrupting agent is a drug designed to damage the vasculature of cancer tumors causing central necrosis.VTAs can be small-molecule or ligand-based....
and a prodrug
Prodrug
A prodrug is a pharmacological substance administered in an inactive form. Once administered, the prodrug is metabolised in vivo into an active metabolite, a process termed bioactivation. The rationale behind the use of a prodrug is generally for absorption, distribution, metabolism, and...
of N-acetylcolchinol, related to colchicine
Colchicine
Colchicine is a medication used for gout. It is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum...
. It has shown promising results on tumor
Tumor
A tumor or tumour is commonly used as a synonym for a neoplasm that appears enlarged in size. Tumor is not synonymous with cancer...
s in mice.
A phase I clinical trial
Clinical trial
Clinical trials are a set of procedures in medical research and drug development that are conducted to allow safety and efficacy data to be collected for health interventions...
identified gastrointestinal and cardiac effects as limiting dosing. Two phase II
Phase II
Phase II may refer to:* Phase II clinical trial* Drug metabolism Phase II* Star Trek: Phase II, a planned Star Trek television series that eventually evolved into Star Trek: The Motion Picture...
clinical trial
Clinical trial
Clinical trials are a set of procedures in medical research and drug development that are conducted to allow safety and efficacy data to be collected for health interventions...
s were started investigating ZD6126 in metastatic renal cell carcinoma and metastatic colorectal cancer.
ZD6126 was being investigated by AstraZeneca as a vascular disrupting agent (VDA). However, the trials were halted, after it became apparent that ZD6126 was too cardiotoxic at the required doses.