Zeda F. Rosenberg, Sc.D.

Doctor of Science

Doctor of Science , usually abbreviated Sc.D., D.Sc., S.D. or Dr.Sc., is an academic research degree awarded in a number of countries throughout the world. In some countries Doctor of Science is the name used for the standard doctorate in the sciences, elsewhere the Sc.D...

, microbiologist

Microbiology

Microbiology is the study of microorganisms, which are defined as any microscopic organism that comprises either a single cell , cell clusters or no cell at all . This includes eukaryotes, such as fungi and protists, and prokaryotes...

, epidemiologist

Epidemiology

Epidemiology is the study of health-event, health-characteristic, or health-determinant patterns in a population. It is the cornerstone method of public health research, and helps inform policy decisions and evidence-based medicine by identifying risk factors for disease and targets for preventive...

 and widely recognized expert in HIV

HIV

Human immunodeficiency virus is a lentivirus that causes acquired immunodeficiency syndrome , a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive...

 biology and prevention, serves as the chief executive officer

Chief executive officer

A chief executive officer , managing director , Executive Director for non-profit organizations, or chief executive is the highest-ranking corporate officer or administrator in charge of total management of an organization...

 of the International Partnership for Microbicides

International Partnership for Microbicides

The International Partnership for Microbicides or IPM is a non-profit product development partnership founded by Dr. Zeda Rosenberg in 2002 to prevent HIV transmission by accelerating the development and availability of a safe and effective microbicide for use by women in developing...

 (IPM). IPM was founded by Dr. Rosenberg in 2002 and is a nonprofit organization

Nonprofit organization

Nonprofit organization is neither a legal nor technical definition but generally refers to an organization that uses surplus revenues to achieve its goals, rather than distributing them as profit or dividends...

 dedicated to developing microbicides

Microbicides for sexually transmitted diseases

Microbicides for sexually transmitted diseases, are pharmacologic agents and chemical substances that are capable of killing or destroying certain microorganisms that commonly cause human infection, for example the human immunodeficiency virus....

 and other innovative HIV prevention products and making them available for women in developing countries

Developing country

A developing country, also known as a less-developed country, is a nation with a low level of material well-being. Since no single definition of the term developing country is recognized internationally, the levels of development may vary widely within so-called developing countries...

.

Dr. Rosenberg received her undergraduate degree (BA) in biology

Biology

Biology is a natural science concerned with the study of life and living organisms, including their structure, function, growth, origin, evolution, distribution, and taxonomy. Biology is a vast subject containing many subdivisions, topics, and disciplines...

 and mathematics

Mathematics

Mathematics is the study of quantity, space, structure, and change. Mathematicians seek out patterns and formulate new conjectures. Mathematicians resolve the truth or falsity of conjectures by mathematical proofs, which are arguments sufficient to convince other mathematicians of their validity...

 from Douglass College, Rutgers University

Rutgers University

Rutgers, The State University of New Jersey , is the largest institution for higher education in New Jersey, United States. It was originally chartered as Queen's College in 1766. It is the eighth-oldest college in the United States and one of the nine Colonial colleges founded before the American...

, and both her master’s degree (SM) in epidemiology

Epidemiology

Epidemiology is the study of health-event, health-characteristic, or health-determinant patterns in a population. It is the cornerstone method of public health research, and helps inform policy decisions and evidence-based medicine by identifying risk factors for disease and targets for preventive...

 and her doctoral degree (ScD) in microbiology

Microbiology

Microbiology is the study of microorganisms, which are defined as any microscopic organism that comprises either a single cell , cell clusters or no cell at all . This includes eukaryotes, such as fungi and protists, and prokaryotes...

 from the Harvard School of Public Health

Harvard School of Public Health

The Harvard School of Public Health is one of the professional graduate schools of Harvard University, located in the Longwood Area of the Boston, Massachusetts neighborhood of Mission Hill, which is next to Harvard Medical School. HSPH is considered a significant school focusing on health in the...

.

Dr. Rosenberg is widely regarded as a steadfast champion for developing new HIV

HIV

Human immunodeficiency virus is a lentivirus that causes acquired immunodeficiency syndrome , a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive...

 prevention products, women’s empowerment and protecting women’s health. Her opinions and commentary have been featured in a variety of international media, including New York Times, The Globe and Mail

The Globe and Mail

The Globe and Mail is a nationally distributed Canadian newspaper, based in Toronto and printed in six cities across the country. With a weekly readership of approximately 1 million, it is Canada's largest-circulation national newspaper and second-largest daily newspaper after the Toronto Star...

 (Canada), The Daily Nation

Daily Nation

The Daily Nation is a Kenyan independent newspaper. It is the most influential newspaper in Kenya with a daily circulation of about 205,000 copies. The total readership is likely to be higher as each copy is read by a large number of people...

 (Kenya), Nature News

Nature (journal)

Nature, first published on 4 November 1869, is ranked the world's most cited interdisciplinary scientific journal by the Science Edition of the 2010 Journal Citation Reports...

 and the South African Medical Journal

South African Medical Journal

The South African Medical Journal is a monthly peer-reviewed open-access medical journal which has been published in South Africa since 1884...

. She has authored many scientific articles and has been a featured speaker at multiple high-level conferences and events, including the IAS Conference on HIV Pathogenesis, Treatment and Prevention

International AIDS Society

The International AIDS Society is an independent association of HIV professionals, with 14,000 members from 190 countries working at all levels of the global response to AIDS. IAS members include researchers from all disciplines, clinicians, public health and community practitioners on the...

, the International AIDS Conference

International AIDS Conference

The International AIDS Society is the custodian of the International AIDS Conference, the largest regular conference on any health or development issue. These conferences provide a forum for the interaction of science, community and leadership, and are claimed to strengthen an evidence-based...

, Women Deliver, and the United Nations General Assembly

United Nations General Assembly

For two articles dealing with membership in the General Assembly, see:* General Assembly members* General Assembly observersThe United Nations General Assembly is one of the five principal organs of the United Nations and the only one in which all member nations have equal representation...

 Special Session on HIV/AIDS.

Early career history

From 1999 to 2002 Dr. Rosenberg was the scientific director for the HIV Prevention Trials Network

HIV Prevention Trials Network

The HIV Prevention Trials Network is an international organization that develops and tests the safety and efficacy of primarily non-vaccine interventions designed to prevent the transmission of HIV....

 (HPTN) at Family Health International

Family Health International

Family Health International is a public health and development organization dedicated to improving living standards of the world's most vulnerable people. Family Health International has 2,500 staff conducting research and implementing programs in fifty-five countries...

 (FHI). In that role, she managed scientific and operational coordination of international clinical trials in the prevention of mother-to-child transmission of HIV, sexual transmission and transmission of HIV through intravenous drug use.

From 1987 to 1999, Dr. Rosenberg worked in several capacities at the National Institute of Allergy and Infectious Diseases

National Institute of Allergy and Infectious Diseases

The National Institute of Allergy and Infectious Diseases is one of the 27 institutes and centers that make up the National Institutes of Health , an agency of the United States Department of Health and Human Services...

 (NIAID) at the U.S. National Institutes of Health

National Institutes of Health

The National Institutes of Health are an agency of the United States Department of Health and Human Services and are the primary agency of the United States government responsible for biomedical and health-related research. Its science and engineering counterpart is the National Science Foundation...

 (NIH). She was senior scientist in the Division of AIDS from 1995 to 1999. In that capacity, she directed HIV prevention clinical trials, providing leadership, planning, implementation, administration and evaluation of a global program of extramural research on the prevention of HIV transmission in adult populations.

Dr. Rosenberg also served as the assistant to the director and then assistant director for prevention research at NIAID from 1987 to 1995. In this position, she was responsible for all scientific research areas related to AIDS

AIDS

Acquired immune deficiency syndrome or acquired immunodeficiency syndrome is a disease of the human immune system caused by the human immunodeficiency virus...

, functioning as a liaison and facilitating scientific exchange between intramural research laboratories and the office of the director. She also coordinated the NIAID Tuberculosis

Tuberculosis

Tuberculosis, MTB, or TB is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. Tuberculosis usually attacks the lungs but can also affect other parts of the body...

 (TB) Research effort, representing NIH on the Public Health Service Task Force to Combat Multi-Drug Resistant TB and co-chairing the TB Research Subcommittee. In addition, she was responsible for coordinating other Institute disease-prevention activities, including in the areas of HIV and other sexually transmitted diseases

Sexually transmitted disease

Sexually transmitted disease , also known as a sexually transmitted infection or venereal disease , is an illness that has a significant probability of transmission between humans by means of human sexual behavior, including vaginal intercourse, oral sex, and anal sex...

.

At IPM

Dr. Rosenberg provides vision, leadership and direction to IPM, which has become a leading product development partnership in the HIV prevention field. Under Dr. Rosenberg’s leadership, IPM has entered into six non-exclusive, royalty-free licenses with five major pharmaceutical companies — Bristol-Myers Squibb

Bristol-Myers Squibb

Bristol-Myers Squibb , often referred to as BMS, is a pharmaceutical company, headquartered in New York City. The company was formed in 1989, following the merger of its predecessors Bristol-Myers and the Squibb Corporation...

, Gilead Sciences

Gilead Sciences

Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes therapeutics. For many years since the company was founded, the company concentrated primarily on antiviral drugs to treat patients infected with HIV, hepatitis B or influenza. In 2006, Gilead acquired two...

, Merck & Co.

Merck & Co.

Merck & Co., Inc. , also known as Merck Sharp & Dohme or MSD outside the United States and Canada, is one of the largest pharmaceutical companies in the world. The Merck headquarters is located in Whitehouse Station, New Jersey, an unincorporated area in Readington Township...

, Pfizer

Pfizer

Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...

 and Tibotec Pharmaceuticals

Tibotec

Tibotec is a pharmaceutical company with a focus on research and development for the treatment of infectious diseases such as HIV , and Hepatitis C...

 (division of Johnson & Johnson

Johnson & Johnson

Johnson & Johnson is an American multinational pharmaceutical, medical devices and consumer packaged goods manufacturer founded in 1886. Its common stock is a component of the Dow Jones Industrial Average and the company is listed among the Fortune 500....

) — to develop, manufacture and distribute eight antiretroviral

Antiretroviral drug

Antiretroviral drugs are medications for the treatment of infection by retroviruses, primarily HIV. When several such drugs, typically three or four, are taken in combination, the approach is known as Highly Active Antiretroviral Therapy, or HAART...

 (ARV) products as microbicides

Microbicides for sexually transmitted diseases

Microbicides for sexually transmitted diseases, are pharmacologic agents and chemical substances that are capable of killing or destroying certain microorganisms that commonly cause human infection, for example the human immunodeficiency virus....

 in developing countries

Developing country

A developing country, also known as a less-developed country, is a nation with a low level of material well-being. Since no single definition of the term developing country is recognized internationally, the levels of development may vary widely within so-called developing countries...

.

In 2011, IPM will initiate a Phase III clinical program to evaluate the dapivirine vaginal ring, an antiretroviral-based product that could potentially provide women with HIV protection for a month or longer. The program will involve up to 6,000 women in many communities throughout sub-Saharan Africa, where the HIV/AIDS epidemic has hit hardest.

Professional affiliations

• International AIDS Society
  International AIDS Society
  The International AIDS Society is an independent association of HIV professionals, with 14,000 members from 190 countries working at all levels of the global response to AIDS. IAS members include researchers from all disciplines, clinicians, public health and community practitioners on the...
  
   (IAS), 2004-current
• Global Health Council
  Global Health Council
  The Global Health Council is a United States-based non-profit networking organizing linking "several hundred health non-governmental organizations around the world to share knowledge and resources, build partnerships and together become stronger advocates for health"...
  
  , 2002-current
• Global HIV Prevention Working Group, 2002-current
• IAS Industry Liaison Forum, 2004-current

Publications

1. Haseltine, W.A., Pederson, F.S., Sahagan, B.G., Rosenberg, Z.F., and Koslov, J. Comparative analysis of RNA tumor virus genomes. In: R. Neth and R. Gallo, eds., Modern Trends in Human Leukemia III, pps. 529-552, Springer-Verlag, Berlin (1979)
2. Rosenberg, Z.F., and Haseltine, W.A. A transfection assay for transformation by feline sarcoma virus proviral DNA. Virology 102: 240-244 (1980).
3. Rosenberg, Z.F., Pederson, F.S. and Haseltine, W.A. Comparative analysis of the genomes of feline leukemia viruses. J. Virol. 35: 542-546 (1980).
4. Rosenberg, Z.F., Snyder, H.W., Jr., and Haseltine, W.A. Characterization of murine cells transformed by feline sarcoma virus (FeSV) proviral DNA. In: W. Hardy, Jr., M. Essex, and A.J. McClelland, eds., Feline Leukemia Virus, Elsevier North-Holland Inc., NY, pps. 335-344 (1980).
5. Rosenberg, Z.F., Pederson, F.S. and Haseltine, W.A. Comparative analysis of the genomes of feline leukemia viruses. In: W. Hardy, Jr., M. Essex, and A.J. McClelland, eds., Feline Leukemia Virus, Elsevier North-Holland Inc., NY, pps. 355-359 (1980).
6. Sahagan, B.G., Rosenberg, Z.F., and Haseltine, W.A. Restriction enzyme analysis of the feline sarcoma virus provirus in murine fibroblasts transformed by transfection. In: W. Hardy, Jr., M. Essex, and A.J. McClelland, eds., Feline Leukemia Virus, Elsevier North-Holland Inc., NY, pps 345-352 (1980).
7. Rosenberg, Z.F., Sahagan, B.G., Snyder, H.W., Jr., Worley, M.B., Essex, M., and Haseltine, W.A. Biochemical characterization of cells transformed via transfection by feline sarcoma virus proviral DNA. J. Virol. 38: 782-788 (1981).
8. Rosenberg, Z.F., Sahagan, B.G., Worley, M.B., Essex, M., and Haseltine, W.A. Transformation with subgenomic fragments of feline sarcoma virus proviral DNA. Virology 112: 496-504 (1981).
9. Rosenberg, Z.F., Crowther, R.L., Essex, M., Jarrett, O. and Haseltine, W.A. Isolation via transfection of feline leukemia viruses from DNA of mediastinal tumors. Virology 115: 203-210 (1981).
10. Koenig, S. and Rosenberg, Z.F. Immunology of infection with the human immunodeficiency virus (HIV): A view from the III International Conference on AIDS. Ann. Intern. Med. 107: 409-412 (1987).
11. Rosenberg, Z.F. and Fauci, A.S. Immunopathogenesis of human immunodeficiency virus infection. Clin. Immunol. News. 9: 1-4 (1988).
12. Rosenberg, Z.F. and Fauci, A.S. Immunopathogenic mechanisms in human immunodeficiency virus (HIV) infections. Ann. N.Y. Acad. Sci. 546:164- 174 (1988).
13. Rosenberg, Z.F. and Fauci, A.S. Update of HIV vaccine trials at the National Institutes of Health. In: M. Girard and L. Valette, eds., Proceedings of the Third Cent Gardes Symposium, Pasteur Vaccine, Marnes-La-Coquette, France, pps.287-292 (1988).
14. Rosenberg, Z.F. and Fauci, A.S. Immunopathogenic mechanism of HIV infection. Clin. Immunol. Immunopathol. 50: S149-S156 (1989).
15. Rosenberg, Z.F. and Fauci, A.S. Induction of expression of HIV in latently or chronically infected cells. AIDS Res. Hum. Retroviruses 5:1-4 (1989).
16. Rosenberg, Z.F. and Fauci, A.S. The immunopathogenesis of HIV infection. Adv. Immunol. 47:377-431 (1989).
17. Rosenberg, Z.F. and Fauci, A.S. Immunology of AIDS: Approaches to understanding the immunopathogenesis of HIV nfection. La Ricerca 19:189-209 (1989).
18. Fauci, A.S. and Rosenberg, Z.F. Immunopathogenic mechanisms of HIV infection. In: F. Melchers et al., eds., Progress in Immunology VII, Springer-Verlag, Berlin, pps. 1028-1035 (1989).
19. Rosenberg, Z.F. and Fauci, A.S. Immunopathogenic Mechanisms of HIV Infection: Cytokine induction of HIV expression. Immunol. Today 11:176-180 (1990).
20. Rosenberg, Z.F. and Fauci, A.S. Immunopathology and pathogenesis of HIV infection. In: P. Pizzo and C. Wilfert, eds., Pediatric AIDS: The Challenge of HIV Infection in Infants, Children, and Adolescents. Williams and Wilkins, Baltimore, MD, pp. 82-94, (1990).
21. Rosenberg, Z.F. and Fauci, A.S. Inside the AIDS Virus. New Scientist 1703:51-54 (1990).
22. Rosenberg,Z.F. and Fauci A.S. Activation of latent HIV nfection. J. NIH Res. 2:41-45 (1990).
23. Fauci, A.S. and Rosenberg, Z.F. Human Retroviruses. In: S. Baron and P.M. Jennings, eds., Medical Microbiology, Churchill Livingstone Inc., New York, pps. 801-816 (1991).
24. Rosenberg, Z.F. and Fauci, A.S. Immunopathogenic mechanisms of HIV infection. In: R.C. Gallo and G. Jay, eds., The Human Retroviruses, Academic Press, Inc., Orlando, Fla., pps. 141-162, (1991).
25. Rosenberg, Z.F. and Fauci, A.S. Immunopathogenesis of HIV infection. FASEB J. 5:2382-2390 (1991).
26. Rosenberg, Z.F. and Fauci, A.S. Immunopathogenesis of human immunodeficiency virus infection. In: W.C. Koff, F. Wong-Staal, and R.C. Kennedy, eds., AIDS Research Reviews, Vol. 1, Marcel Dekker, Inc., N.Y., pp. 65-80, (1991).
27. Rosenberg, Z.F. and Fauci, A.S. Immunopathogenesis of HIV infection. In: V. T. DeVita, Jr., S. Hellman, and S. A. Rosenberg, eds., AIDS: Etiology, Diagnosis, Treatment and Prevention, 3rd ed., J. B. Lippincott Company, Philadelphia, pp. 61-76, (1992).
28. Rosenberg, Z.F. and Fauci, A.S. Immunopathogenesis of HIV infection. In: T. C. Quinn, ed., Advances in Host Defense Mechanisms (Sexually Transmitted Diseases), Vol. 8. Raven Press, N. Y., pp. 165-200, (1992).
29. Rosenberg, Z.F. The research agenda: NIH research portfolio. In: Tuberculosis in New York City, Proceedings of the Julia M. Jones Sixth Annual Preventive Medicine Day, New York Lung Association, November 5, 1992, New York, N.Y., pp 4-5, (1992).
30. Rosenberg, Z.F. and Fauci, A.S. Immunology of HIV infection. In: W.E. Paul, ed., Fundamental Immunology, Third Edition, Raven Press, New York, NY, pp. 1375-1397, (1993).
31. Rosenberg, Z.F. and Fauci, A.S. Immunopathology and pathogenesis of HIV infection. In: P. Pizzo and C. Wilfert, eds., Pediatric AIDS: The Challenge of HIV Infection in Infants, Children, and Adolescents (2nd edition). Williams and Wilkins, Baltimore, MD, pp. 115-127, (1994).
32. Fauci, A.S. and Rosenberg, Z.F. Immunopathogenesis. In: S. Broder, T.C. Merigan, Jr., and D. Bolognesi, eds., Textbook of AIDS Medicine, Williams and Wilkins, Baltimore, MD, pp. 55-75, (1994).
33. Van Damme, L. and Rosenberg, Z.F. Microbicides and Barrier Methods in HIV Prevention. AIDS (13; Suppl A): S85-92; 1999.
34. Mayer, K.H., Peipert, J., Fleming, T., Fullem, A., Moench, T., Cu-Uvin, S., Bentley, M., Chesney, M., and Rosenberg, Z. Safety and Tolerability of Buffergel, a Novel Vaginal Microbicide, in Women in the United States. Clin. Infect. Dis. 32: 476-82; 2001.
35. Mauck, C., Rosenberg, Z., and Van Damme, L. Recommendations for the Clinical Development of Topical Microbicides: an Update. AIDS 15:857-868, 2001.
36. Cates, W., Jr., Rosenberg, Z., and Raymond, E. When Should the Public Be Informed of the Results of Medical Research? [Letter] JAMA 286: 2944-45, 2001.
37. Rosenberg, Z. and Brown, G. Placing HIV Prevention in the Hands of Women: The Promise of Microbicides. SDI/UGF World Summit 2002.
38. Rosenberg, Z. A New Public-Private Partnership for Microbicides. Health and Sexuality 7: 15-17, 2002.
39. Mayer, K.H., Abdool Karim, S., Kelly, C., Maslankowski, L., Rees, H., Profy, A.T., Day, J., Welch, J., Rosenberg, Z., for the HIV Prevention Trials Network (HPTN) 020 Protocol Team. Safety and Tolerability of Vaginal PRO 2000 Gel in Sexually Active HIV-uninfected and Abstinent HIV-infected Women. AIDS 17: 321-329, 2003.
40. Harrison, P., Rosenberg, Z, and Bowcut, J. Topical Microbicides for Disease Prevention: Challenges and Opportunities for Scientific Collaboration. Clin Infect Dis 36: 1290-1294, 2003.
41. Coplan, P.M , Mitchnick, M, Rosenberg Z.F. Public Health: Regulatory Challenges in Microbicide Development. Science 304:1911-2, 2004.
42. Hoffman, I.F., Taha, T.E., Padian, N.S., Kelly, C.W., Welch, J.D., Martins.on, F.E., Kumwenda, N.I., Rosenberg, Z.F., Chilongozi, D.A., Brown J.M., Chirenje, M, Richardson, B.A. Nonoxynol-9 100 mg gel: multi-site safety study from sub-Saharan Africa. AIDS 18:2191-2195, 2004.
43. Tassiopoulos, K.K., Seage, G., Sam, N., Kiweli, I., Shao, J., Trong, T.H., Essex, M., Coplan, P., Rosenberg, Z., Hughes, M., Kapiga, S. Predictors of herpes simplex type 2 prevalence and incidence among bar and hotel workers in Moshi, Tanzania. J Infect Dis 195: 493-501, 2007
44. Kapiga, S.H., Sam N.E., Bang, H., Ni, Q, Ao, T.T., Kiwelu, I., Chiduo, S., Ndibe, U., Seage, G. 3rd, Coplan, P., Shao, J., Rosenberg, Z.F., Essex, M. The role of herpes simplex virus type 2 and other genital infections in the acquisition of HIV-1 among high-risk women in northern Tanzania. J Infect Dis 195:1260-1269, 2007
45. Nuttall, J., Romano, J., Douville, K., Galbreath, C., Nel, A., Heyward, W., Mitchnick, M., Walker, S., Rosenberg, Z. The future of HIV prevention: prospects for an effective anti-HIV microbicide. Infect Dis Clin N Am 21: 219-239, 2007
46. Nuttall, J., Douville, K., Galbreath, C., Walker, S., Norick, P., Rosenberg, Z. Challenges of producing a drug primarily for use in developing countries: microbicides for HIV prevention. Therapy 4: 725-730, 2007
47. Cates, W. and Rosenberg, Z. Vaginal microbicides: What does the future hold? Contemp OBGYN pgs 22-28, April 15, 2008
48. Romano J, Variano B, Coplan P, Van Roey J, Douville K, Rosenberg Z, Temmerman M, Verstraelen H, Van Bortel L, Weyers S, Mitchnick M. Safety and availability of dapivirine (TMC120) delivered from an intravaginal ring. AIDS Res Hum Retro. 25: 483-488, 2009.
49. Nel A, Smythe S, Young K, Malcolm K, McCoy C, Rosenberg Z, Romano J. Safety and pharmacokinetics of dapivirine delivery from matrix and reservoir intravaginal rings to HIV-negative women. J Acquir Immune Defic Syndr. 51: 416-423, 2009.