Zolazepam
Encyclopedia
Zolazepam was discoverd by a team at Parke-Davis in the 1960s.(Flupyrazapon) is a pyrazolodiazepinone derivative structurally related to the benzodiazepine
drugs, which is used as an anaesthetic for a wide range of animals in veterinary medicine. Zolazepam is usually administered in combination with other drugs such as the NMDA
antagonist
tiletamine
or the alpha-2 adrenergic receptor
agonist
xylazine
, depending on what purpose it is being used for.
Zolazepam was developed by Horace A. de Wald and Donald E. Butler for Parke Davis and was the result of a very detailed analysis of the benzodiazepine structure (US Patent 3,558,605 filed in 1969).
Zolazepam, in combination with tiletamine
, has been used in the tranquilization of wild animals, such as gorillas and polar bears, and has been found to be in terms of reduced side-effects superior to ketamine
.
Benzodiazepine
A benzodiazepine is a psychoactive drug whose core chemical structure is the fusion of a benzene ring and a diazepine ring...
drugs, which is used as an anaesthetic for a wide range of animals in veterinary medicine. Zolazepam is usually administered in combination with other drugs such as the NMDA
NMDA
N-Methyl-D-aspartic acid or N-Methyl-D-aspartate is an amino acid derivative which acts as a specific agonist at the NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor...
antagonist
Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that does not provoke a biological response itself upon binding to a receptor, but blocks or dampens agonist-mediated responses...
tiletamine
Tiletamine
Tiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist. It is related chemically and pharmacologically to other anesthetics in this family such as ketamine and phencyclidine...
or the alpha-2 adrenergic receptor
Adrenergic receptor
The adrenergic receptors are a class of metabotropic G protein-coupled receptors that are targets of the catecholamines, especially noradrenaline and adrenaline ....
agonist
Agonist
An agonist is a chemical that binds to a receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance...
xylazine
Xylazine
Xylazine is a drug that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. An analogue of clonidine, it is an agonist at the α2 class of adrenergic receptor....
, depending on what purpose it is being used for.
Zolazepam was developed by Horace A. de Wald and Donald E. Butler for Parke Davis and was the result of a very detailed analysis of the benzodiazepine structure (US Patent 3,558,605 filed in 1969).
Zolazepam, in combination with tiletamine
Tiletamine
Tiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist. It is related chemically and pharmacologically to other anesthetics in this family such as ketamine and phencyclidine...
, has been used in the tranquilization of wild animals, such as gorillas and polar bears, and has been found to be in terms of reduced side-effects superior to ketamine
Ketamine
Ketamine is a drug used in human and veterinary medicine. Its hydrochloride salt is sold as Ketanest, Ketaset, and Ketalar. Pharmacologically, ketamine is classified as an NMDA receptor antagonist...
.