Zona pellucida-like domain
Encyclopedia
Zona pellucida-like domain (ZP domain / ZP-like domain) is a family of evolutionarily related proteins
.
A large domain, containing around 260 amino acids, has been recognised in a variety of receptor-like eukaryotic glycoprotein
s. All of these proteins are mosaic proteins composed of various domains and that all have a large extracellular region, often followed by either a transmembrane region and a very short cytoplasmic
region or by a GPI-anchor. The domain common to all these proteins is a bipartite protein polymerization module that is located in the C-terminal portion of the extracellular region and contains 8 or 10 conserved Cys residues involved in disulfide bonds.
Protein family
A protein family is a group of evolutionarily-related proteins, and is often nearly synonymous with gene family. The term protein family should not be confused with family as it is used in taxonomy....
.
A large domain, containing around 260 amino acids, has been recognised in a variety of receptor-like eukaryotic glycoprotein
Glycoprotein
Glycoproteins are proteins that contain oligosaccharide chains covalently attached to polypeptide side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. In proteins that have segments extending...
s. All of these proteins are mosaic proteins composed of various domains and that all have a large extracellular region, often followed by either a transmembrane region and a very short cytoplasmic
Cytoplasm
The cytoplasm is a small gel-like substance residing between the cell membrane holding all the cell's internal sub-structures , except for the nucleus. All the contents of the cells of prokaryote organisms are contained within the cytoplasm...
region or by a GPI-anchor. The domain common to all these proteins is a bipartite protein polymerization module that is located in the C-terminal portion of the extracellular region and contains 8 or 10 conserved Cys residues involved in disulfide bonds.
Examples
Humans genes encoding proteins containing this domain include:- CUZD1CUZD1CUB and zona pellucida-like domain-containing protein 1 is a protein that in humans is encoded by the CUZD1 gene.-Further reading:...
- DMBT1DMBT1Deleted in malignant brain tumors 1 protein is a protein that in humans is encoded by the DMBT1 gene.-Interactions:DMBT1 has been shown to interact with Surfactant protein D.-Further reading:...
- ENGEndoglinEndoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex.The protein consists of a homodimer of 180 kDA with disulfide links....
- GP2GP2 (gene)Pancreatic secretory granule membrane major glycoprotein GP2 is a protein that in humans is encoded by the GP2 gene.-Further reading:...
- OIT3
- POMZP3
- TECTATECTAAlpha-tectorin is a protein that in humans is encoded by the TECTA gene.-Further reading:...
, TECTBTECTBBeta-tectorin is a protein that in humans is encoded by the TECTB gene.- Function :The genes for alpha-tectorin and beta-tectorin encode the major noncollagenous proteins of the tectorial membrane of the cochlea.-Further reading:...
, TGFBR3 - UMODTamm-Horsfall proteinThe Tamm-Horsfall glycoprotein also known as uromodulin is a glycoprotein that in humans is encoded by the UMOD gene. Up to 150 mg/dl of uromodulin may be excreted in the urine, making it the most abundant protein in normal urine.- Gene :...
, UMODL1 - ZP1, ZP2ZP2Zona pellucida sperm-binding protein 2 is a protein that in humans is encoded by the ZP2 gene.-Further reading:...
, ZP3ZP3Zona pellucida sperm-binding protein 3, also known as zona pellucida glycoprotein 3 or the sperm receptor, is a protein that in humans is encoded by the ZP3 gene...
, ZP4ZP4Zona pellucida sperm-binding protein 4 is a protein that in humans is encoded by the ZP4 gene.- Function :The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and...
, ZPLD1