5-tryptamine is a tryptamine

Tryptamine

Tryptamine is a monoamine alkaloid found in plants, fungi, and animals. It is based around the indole ring structure, and is chemically related to the amino acid tryptophan, from which its name is derived...

 derivative which acts as a selective agonist

Agonist

An agonist is a chemical that binds to a receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance...

 at the 5-HT_1D

5-HT1D receptor

5-hydroxytryptamine receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it. 5-HT1D acts on the central nervous system, and affects locomotion and anxiety...

 serotonin

Serotonin

Serotonin or 5-hydroxytryptamine is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract, platelets, and in the central nervous system of animals including humans...

 receptor

Receptor (biochemistry)

In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism...

. Increasing the O-alkoxy chain length in this series gives generally increasing potency and selectivity for 5-HT_1D, with highest activity found for the nonyloxy derivative, having a 5-HT_1D binding affinity of 1.0nM, and around 300x selectivity over the related 5-HT_1A receptor.

See also

• 5-Benzyloxytryptamine
  5-Benzyloxytryptamine
  5-Benzyloxytryptamine , is a tryptamine derivative which acts as an agonist at the 5-HT1D, 5-HT2 and 5-HT6 serotonin receptors.- See also :* 5-Carboxamidotryptamine* 5-Methoxytryptamine* BW-723C86* Sumatriptan- References :...
  
  
• 5-Carboxamidotryptamine
  5-Carboxamidotryptamine
  5-Carboxamidotryptamine is a tryptamine derivative closely related to the neurotransmitter serotonin.5-CT acts as a non-selective, high-affinity full agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, and 5-HT7 receptors, as well as at the 5-HT2, 5-HT3, 5-HT6 receptors with lower affinity. It has...
  
  
• 5-Ethoxy-DMT
  5-Ethoxy-DMT
  5-Ethoxy-N,N-dimethyltryptamine is a tryptamine derivative, which has been previously synthesised as a chemical intermediate, but has not been studied to determine its pharmacology...
  
  
• Sumatriptan
  Sumatriptan
  Sumatriptan is a triptan sulfa drug containing a sulfonamide group. It is used for the treatment of migraine headaches. Sumatriptan is produced and marketed by various drug manufacturers with many different trade names such as Sumatriptan, Imitrex, Imigran, Imigran recovery.-Approval and...