8-Aminoquinoline is a form of aminoquinoline

Aminoquinoline

Aminoquinoline are derivatives of quinoline, most notable for their roles as antimalarial drugs.Depending upon the location of the amino group, they can be divided into:* 4-Aminoquinoline* 8-Aminoquinoline...

 with an amine

Amine

Amines are organic compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are derivatives of ammonia, wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group. Important amines include amino acids, biogenic amines,...

 at the 8-position of quinoline

Quinoline

Quinoline is a heterocyclic aromatic organic compound. It has the formula C9H7N and is a colourless hygroscopic liquid with a strong odour. Aged samples, if exposed to light, become yellow and later brown...

.

The 8-aminoquinoline family of drugs contains three members, primaquine

Primaquine

Primaquine is a medication used in the treatment of malaria and Pneumocystis pneumonia. It is a member of the 8-aminoquinoline group of drugs that includes tafenoquine and pamaquine.-Radical cure:...

, tafenoquine

Tafenoquine

Tafenoquine is an 8-aminoquinoline drug manufactured by GlaxoSmithKline that is currently being investigated as a potential treatment for malaria, as well as for malaria prevention....

 and pamaquine

Pamaquine

Pamaquine is an 8-aminoquinoline drug used for the treatment of malaria. It is closely related to primaquine.-Adverse effects:Like primaquine, pamaquine causes haemolytic anaemia in patients with G6PD deficiency...

 and are used in the treatment of malaria

Malaria

Malaria is a mosquito-borne infectious disease of humans and other animals caused by eukaryotic protists of the genus Plasmodium. The disease results from the multiplication of Plasmodium parasites within red blood cells, causing symptoms that typically include fever and headache, in severe cases...

. They may be used to eradicate malaria hypnozoites from the liver and have both been used for malaria prophylaxis

Malaria prophylaxis

Malaria prophylaxis is a preventative treatment of malaria.Most adults from endemic areas have a degree of long-term infection, which tends to recur, and also possess partial immunity ; the resistance reduces with time, and such adults may become susceptible to severe malaria if they have spent a...

.

The 8-aminoquinoline drugs must not be given to patients with G6PD deficiency, because they cause potentially fatal haemolysis in these patients.

Pamaquine

Pamaquine

Pamaquine is an 8-aminoquinoline drug used for the treatment of malaria. It is closely related to primaquine.-Adverse effects:Like primaquine, pamaquine causes haemolytic anaemia in patients with G6PD deficiency...

 is no longer available anywhere, but primaquine is still used routinely worldwide as part of the treatment of Plasmodium vivax

Plasmodium vivax

Plasmodium vivax is a protozoal parasite and a human pathogen. The most frequent and widely distributed cause of recurring malaria, P. vivax is one of the four species of malarial parasite that commonly infect humans. It is less virulent than Plasmodium falciparum, which is the deadliest of the...

and Plasmodium ovale

Plasmodium ovale

Plasmodium ovale is a species of parasitic protozoa that causes tertian malaria in humans. It is closely related to Plasmodium falciparum and Plasmodium vivax, which are responsible for most malaria. It is rare compared to these two parasites, and substantially less dangerous than P...

malaria. Tafenoquine

Tafenoquine

Tafenoquine is an 8-aminoquinoline drug manufactured by GlaxoSmithKline that is currently being investigated as a potential treatment for malaria, as well as for malaria prevention....

is currently in Phase III clinical trials and is not yet available to prescribe.