AM-2233 is a drug which acts as a highly potent full agonist for the cannabinoid receptor

Cannabinoid receptor

The cannabinoid receptors are a class of cell membrane receptors under the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains...

s, with a K_i

Dissociation constant

In chemistry, biochemistry, and pharmacology, a dissociation constant is a specific type of equilibrium constant that measures the propensity of a larger object to separate reversibly into smaller components, as when a complex falls apart into its component molecules, or when a salt splits up into...

 of 1.8nM at CB₁ and 2.2nM at CB₂ as the active (R) enantiomer

Enantiomer

In chemistry, an enantiomer is one of two stereoisomers that are mirror images of each other that are non-superposable , much as one's left and right hands are the same except for opposite orientation. It can be clearly understood if you try to place your hands one over the other without...

. It was developed as a selective radioligand for the cannabinoid receptors and has been used as its ¹³¹I

Iodine-131

Iodine-131 , also called radioiodine , is an important radioisotope of iodine. It has a radioactive decay half-life of about eight days. Its uses are mostly medical and pharmaceutical...

 derivative for mapping the distribution of the CB₁ receptor in the brain. AM-2233 was found to fully substitute for THC

Tetrahydrocannabinol

Tetrahydrocannabinol , also known as delta-9-tetrahydrocannabinol , Δ1-THC , or dronabinol, is the main chemical psychoactive substance found in the cannabis plant. It was first isolated in 1964. In pure form, it is a glassy solid when cold, and becomes viscous and sticky if warmed...

 in rats, with a potency lower than that of JWH-018

JWH-018

JWH-018 or AM-678 is an analgesic chemical from the naphthoylindole family, which acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2...

 but higher than WIN 55,212-2

WIN 55,212-2

WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, that produces effects similar to those of cannabinoid derivatives such as THC but has an entirely different chemical structure....

.

See also

• AM-679
  AM-679 (cannabinoid)
  AM-679 is a drug which acts as a moderately potent agonist for the cannabinoid receptors, with a Ki of 13.5nM at CB1 and 49.5nM at CB2. AM-679 was one of the first 3-indole derivatives that was found to have significant cannabinoid receptor affinity, and while AM-679 itself has only modest affinity...
  
  
• AM-694
  AM-694
  AM-694 is a drug which acts as a potent and selective agonist for the cannabinoid receptor CB1, with a Ki of 0.08nM at CB1 and 18x selectivity over the related CB2 receptor....
  
  
• AM-1220
  AM-1220
  AM-1220 is a drug which acts as a potent and moderately selective agonist for the cannabinoid receptor CB1, with around 19x selectivity for CB1 over the related CB2 receptor...
  
  
• AM-1221
  AM-1221
  AM-1221 is a drug which acts as a potent and selective agonist for the cannabinoid receptor CB2, with a Ki of 0.28nM at CB2 and 52.3nM at the CB1 receptor, giving it around 180x selectivity for CB2. The 2-methyl and 6-nitro groups on the indole ring both tend to increase CB2 affinity while...
  
  
• AM-1241
  AM-1241
  AM-1241 is a chemical from the aminoalkylindole family, which acts as a potent and selective agonist for the cannabinoid receptor CB2, with a Ki of 3.4nM at CB2 and 80x selectivity over the related CB1 receptor...
  
  
• Cannabipiperidiethanone
  Cannabipiperidiethanone
  Cannabipiperidiethanone, or 1--3-indole, is a synthetic cannabinoid which has been found as an ingredient of "herbal" synthetic cannabis blends sold in Japan, alongside JWH-122 and JWH-081...