Cannabipiperidiethanone, or 1-(N-methylpiperidin-2-ylmethyl)-3-(2-methoxyphenylacetyl)indole, is a synthetic cannabinoid which has been found as an ingredient of "herbal" synthetic cannabis blends sold in Japan, alongside JWH-122

JWH-122

JWH-122 is a synthetic cannabimimetic that was discovered by John W. Huffman. It has a Ki of 0.69 nM at CB1 and 1.2 nM at CB2....

 and JWH-081

JWH-081

JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. With a Ki of 1.2nM it is fairly selective for the CB1 subtype, its affinity at this subtype approximately 10x the affinity at CB2. It was discovered by and named...

. Its binding affinity was measured at the cannabinoid receptor

Cannabinoid receptor

The cannabinoid receptors are a class of cell membrane receptors under the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains...

s CB₁ and CB₂ and it was found to have an IC₅₀ of 591nM at CB₁ and 968nM at CB₂, making it 2.3x and 9.4x weaker than JWH-250

JWH-250

JWH-250 or is an analgesic chemical from the phenylacetylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors, with a Ki of 11nM at CB1 and 33nM at CB2...

at these two targets respectively.