JWH-250
Encyclopedia
JWH-250 or is an analgesic
chemical from the phenylacetylindole family, which acts as a cannabinoid agonist
at both the CB1 and CB2
receptors, with a Ki
of 11nM at CB1 and 33nM at CB2. Unlike many of the older JWH series compounds, this compound does not have a naphthalene
ring, instead occupying this position with a 2'-methoxy-phenylacetyl group, making JWH-250 a representative member of a new class of cannabinoid ligands. Other 2'-substituted analogues such as the methyl
, chloro
and bromo
compounds are also active and somewhat more potent.
. He created JWH-250 and a number of other compounds to research the structure and function of the endocannabinoid system of mammal
s.
Samples of JWH-250 were first identified in May 2009 by the German Federal Criminal Police, as an ingredient in new generation "herbal smoking blends
" which had been released since the banning of the original ingredients (C8)-CP 47,497 and JWH-018
.
Competition,consumer awareness of the active components,and recent market trends have driven down the capital needed to buy JWH and other research chemicals such as these to a few US dollars per gram on the retail and wholesale markets.
Analgesic
An analgesic is any member of the group of drugs used to relieve pain . The word analgesic derives from Greek an- and algos ....
chemical from the phenylacetylindole family, which acts as a cannabinoid agonist
Agonist
An agonist is a chemical that binds to a receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance...
at both the CB1 and CB2
Cannabinoid receptor 2 (macrophage)
Cannabinoid receptor 2 , also known as CB2 or CNR2, is a G protein-coupled receptor from the cannabinoid receptor family, which in humans is encoded by the CNR2 gene...
receptors, with a Ki
Dissociation constant
In chemistry, biochemistry, and pharmacology, a dissociation constant is a specific type of equilibrium constant that measures the propensity of a larger object to separate reversibly into smaller components, as when a complex falls apart into its component molecules, or when a salt splits up into...
of 11nM at CB1 and 33nM at CB2. Unlike many of the older JWH series compounds, this compound does not have a naphthalene
Naphthalene
Naphthalene is an organic compound with formula . It is a white crystalline solid with a characteristic odor that is detectable at concentrations as low as 0.08 ppm by mass. As an aromatic hydrocarbon, naphthalene's structure consists of a fused pair of benzene rings...
ring, instead occupying this position with a 2'-methoxy-phenylacetyl group, making JWH-250 a representative member of a new class of cannabinoid ligands. Other 2'-substituted analogues such as the methyl
JWH-251
JWH-251 is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 5x selectivity for CB1 with a Ki of 29nM and 146nM at CB2...
, chloro
JWH-203
JWH-203 is an analgesic chemical from the phenylacetylindole family, which acts as a cannabinoid agonist with approximately equal affinity at both the CB1 and CB2 receptors, having a Ki of 8.0nM at CB1 and 7.0nM at CB2...
and bromo
JWH-249
JWH-249 is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 2.4x selectivity for CB1 with a Ki of 8.4nM ± 1.8 and 20nM ± 2 at CB2...
compounds are also active and somewhat more potent.
History
JWH-250 was discovered by, and named after the researcher Dr. John W. HuffmanJohn W. Huffman
John William Huffman is a professor emeritus of organic chemistry at Clemson University who first synthesised many novel cannabinoids, including JWH-007, JWH-015, JWH-018, JWH-019, JWH-030, JWH-051, JWH-073, JWH-081, JWH-122, JWH-133, JWH-147, JWH-171, JWH-182, JWH-203, JWH-210, JWH-250, JWH-307,...
. He created JWH-250 and a number of other compounds to research the structure and function of the endocannabinoid system of mammal
Mammal
Mammals are members of a class of air-breathing vertebrate animals characterised by the possession of endothermy, hair, three middle ear bones, and mammary glands functional in mothers with young...
s.
Samples of JWH-250 were first identified in May 2009 by the German Federal Criminal Police, as an ingredient in new generation "herbal smoking blends
Spice (drug)
Synthetic cannabis is a psychoactive herbal and chemical product which, when consumed, mimics the effects of cannabis. It is best known by the brand names K2 and Spice, both of which have largely become genericized trademarks used to refer to any synthetic cannabis product...
" which had been released since the banning of the original ingredients (C8)-CP 47,497 and JWH-018
JWH-018
JWH-018 or AM-678 is an analgesic chemical from the naphthoylindole family, which acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2...
.
Competition,consumer awareness of the active components,and recent market trends have driven down the capital needed to buy JWH and other research chemicals such as these to a few US dollars per gram on the retail and wholesale markets.