• JWH-007
  JWH-007
  JWH-007 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It was the most active of the first group of N-alkyl naphoylindoles discovered by the team led by John W Huffman, several years after the family was initially...
  
   — an analgesic
  Analgesic
  An analgesic is any member of the group of drugs used to relieve pain . The word analgesic derives from Greek an- and algos ....
  
   chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB₁ receptor and CB₂ receptors, with some selectivity for CB₂ with a K_i of 2.9nM ± 2.6 and 9.5nM ± 4.5 at CB₁.
• JWH-015
  JWH-015
  JWH-015 is a chemical from the naphthoylindole family, which acts as a subtype-selective cannabinoid agonist. Its affinity for CB2 receptors is 13.8nM, while its affinity for CB1 is 383nM, meaning that it binds almost 28x more strongly to CB2 than CB1. However it still displays some weak CB1...
  
   — a chemical from the naphthoylindole family, which acts as a subtype-selective cannabinoid agonist. Its affinity for CB₂ receptors is 13.8nM, while its affinity for CB₁ is 383nM, meaning that it binds almost 28x more strongly to CB₂ than CB₁.
• JWH-018
  JWH-018
  JWH-018 or AM-678 is an analgesic chemical from the naphthoylindole family, which acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2...
  
   — an analgesic chemical from the naphthoylindole family, which acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, with some selectivity for CB₂ with a K_i of 2.9nM ± 2.6 and 9nM ± 5 at CB₁.
• JWH-019
  JWH-019
  JWH-019 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is the N1-hexyl homologue of the more common synthetic cannabinoid compound JWH-018...
  
   — an agonist at both CB₁ and CB₂ receptors, it has 1.77x selectivity for CB₂ with a K_i of 5.55nM ± 2 and 9.8nM ± 2 at CB₁.
• JWH-030
  JWH-030
  JWH-030 is a research chemical which is a cannabinoid receptor agonist. It has analgesic effects and is used in scientific research. It is a partial agonist at CB1 receptors, with a Ki of 87nM, making it roughly half the potency of THC. It was discovered and named after Dr. John W. Huffman....
  
   — an analgesic chemical from the naphthoylpyrrole family, it is a partial agonist at CB₁ receptors, with a K_i of 87nM, making it roughly half the potency of THC.
• JWH-047 —
• JWH-048 — a potent and selective agonist for the CB₂ receptor with a K_i of 0.49nM ± 0.1 and 10.7nM ± 1.0 at CB₁, it has a 22x selectivity for CB₂.
• JWH-051
  JWH-051
  JWH-051 is an analgesic drug which is a cannabinoid agonist. Its chemical structure is closely related to that of the potent cannabinoid agonist HU-210, with the only difference being the removal of the hydroxyl group at position 1 of the aromatic ring. It was discovered and named after Dr. John W...
  
   — an analgesic, it has high affinity for the CB₁ receptor, but is a much stronger agonist for CB₂, with a K_i value of 0.03nM at CB₂ vs 1.20nM at CB₁. It was one of the first CB₂-selective ligands developed, although its selectivity for CB₂ is modest compared to newer compounds such as HU-308
  HU-308
  HU-308 is a drug which acts as a cannabinoid agonist. It is highly selective for the CB2 receptor subtype, with a selectivity of over 5000x for CB2 vs CB1. The synthesis and characterization took place in the laboratory of Prof. Mechoulam at the Hebrew University of Jerusalem in the late 1990s...
  
  .
• JWH-057 — a 1-deoxy analog of Δ8-THC that has very high affinity for the CB₂ receptor, but also has high affinity for the CB₁ receptor.
• JWH-073
  JWH-073
  JWH-073 is an analgesic chemical from the naphthoylindole family, which acts as a partial agonist at both the CB1 and CB2 cannabinoid receptors. It is somewhat selective for the CB1 subtype, with affinity at this subtype approximately 5x the affinity at CB2. The abbreviation JWH stands for John W...
  
   — an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors. It is somewhat selective for the CB₁ subtype with a K_i of 8.9nM.
• JWH-081
  JWH-081
  JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. With a Ki of 1.2nM it is fairly selective for the CB1 subtype, its affinity at this subtype approximately 10x the affinity at CB2. It was discovered by and named...
  
   — an analgesic chemical from the naphthoylindole family, which acts as an agonist at both the cannabinoid receptors with a K_i of 1.2nM ± 0.03 at CB₁ and 12.4nM ± 2.2 at the CB₂ receptors. It is fairly selective for the CB₁ subtype with approximately 10x the affinity for CB₂.
• JWH-098
  JWH-098
  JWH-098 is a synthetic cannabinoid receptor agonist from the naphthoylindole family. It is the indole 2-methyl derivative of a closely related compound JWH-081, but has markedly different affinity for the CB1 and CB2 receptors...
  
   — a potent and fairly selective CB₂ agonist with a K_i of 1.9nM ± 0.3 at CB₂ and 4.5nM ± 0.1 at CB₁, giving it about 2.4x selectivity for CB₂.
• JWH-116 —
• JWH-120 — a potent and 173-fold selective CB₂ agonist with a K_i of 6.1nM ± 0.7, it is the N-propyl homolog of JWH-122.
• JWH-122
  JWH-122
  JWH-122 is a synthetic cannabimimetic that was discovered by John W. Huffman. It has a Ki of 0.69 nM at CB1 and 1.2 nM at CB2....
  
   — a potent and fairly selective CB₁ agonist with a K_i of 0.69nM ± 0.5 at CB₁ and 1.2nM ± 1.2 at CB₂.
• JWH-133
  JWH-133
  JWH-133 is a potent selective CB2 receptor agonist, with a Ki of 3.4nM and selectivity of around 200x for CB2 over CB1 receptors. It was discovered by, and named after, John W...
  
   — a potent and highly selective CB₂ receptor agonist with a K_i of 3.4nM and selectivity of around 200x for CB₂ over CB₁ receptors.
• JWH-139 — 3-(1,1-dimethylpropyl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromene
• JWH-147
  JWH-147
  JWH-147 is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is somewhat selective for the CB2 subtype, with a Ki of 11.0nM at CB1 vs 7.1nM at CB2. It was discovered and named after Dr. John W. Huffman...
  
   — an analgesic drug from the naphthoylpyrrole family, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors. It is somewhat selective for the CB₂ subtype, with a K_i of 11.0nM at CB₁ vs 7.1nM at CB₂.
• JWH-148 —
• JWH-149 — a potent and fairly selective CB₂ agonist with a K_i of 0.73nM ± 0.03 and 5.0nM ± 2.1 at CB₁, giving it about 6.8x selectivity for CB₂.
• JWH-161
  JWH-161
  JWH-161 is a cannabinoid derivative that was designed by Dr John W. Huffman's team as a hybrid between the dibenzopyran "classical" cannabinoid drugs and the novel indole derivatives, in an attempt to unravel the differences in their binding modes to the CB1 receptor...
  
   —
• JWH-164
  JWH-164
  JWH-164 is a synthetic cannabinoid receptor agonist from the naphthoylindole family. It has approximately equal affinity for the CB1 and CB2 receptors, with a Ki of 6.6nM at CB1 and 6.9nM at CB2. JWH-164 is a positional isomer of the related compound JWH-081, but with a methoxy group at the...
  
   — a potent cannabinoid agonist with a K_i of 6.6nM ± 0.7 at CB₁ and 6.9nM ± 0.2 at CB₂.
• JWH-166 — a potent and highly selective CB₂ agonist with a K_i of 1.9nM ± 0.08 at CB₂ and 44nM ± 10 at CB₁ giving it 23x selectivity for CB₂.
• JWH-167
  JWH-167
  JWH-167 is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 1.75x selectivity for CB2 with a Ki of 90nM ± 17 and 159nM ± 14 at CB1...
  
   — a weak cannabinoid agonist from the phenylacetylindole family with 1.77x selectivity for CB₁ with a K_i of 90nM ± 17 at CB₁ and 159nM ± 14 at CB₂.
• JWH-171
  JWH-171
  JWH-171 is an analgesic drug which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is only 51.0nM, making it slightly less potent than THC itself, however JWH-171 is particularly notable in that it is a hydrocarbon containing no heteroatoms...
  
   — an analgesic drug which acts as a cannabinoid receptor agonist. Its binding affinity at the CB₁ receptor is only 51nM, making it slightly less potent than THC itself.
• JWH-175
  JWH-175
  JWH-175 is a drug from the naphthylmethylindole family which acts as a cannabinoid receptor agonist. It was invented by the scientist John W. Huffman and colleagues at Clemson University. JWH-175 is closely related to the widely used cannabinoid designer drug JWH-018, but with the ketone bridge...
  
   —
• JWH-176 —
• JWH-181 — a potent cannabinoid agonist with 2.1x selectivity for CB₂ with a K_i of 0.62nM ± 0.04 and 1.3nM ± 0.1 at CB₁.
• JWH-182 — a potent cannabinoid agonist with some selectivity for CB₁ with a K_i of 0.65nM ± 0.03 and 1.1nM ± 0.1 at CB₂.
• JWH-184 —
• JWH-185 —
• JWH-192 —
• JWH-193
  JWH-193
  JWH-193 is a drug from the aminoalkylindole family which acts as a cannabinoid receptor agonist. It was invented by the pharmaceutical company Sanofi-Winthrop in the early 1990s. JWH-193 has a binding affinity at the CB1 receptor of 6nM, binding around seven times more tightly than the parent...
  
   — 6nM at CB₁
• JWH-194 —
• JWH-195 —
• JWH-196 —
• JWH-197 —
• JWH-198
  JWH-198
  JWH-198 is a drug from the aminoalkylindole family which acts as a cannabinoid receptor agonist. It was invented by the pharmaceutical company Sanofi-Winthrop in the early 1990s. JWH-198 has a binding affinity at the CB1 receptor of 10nM, binding around four times more tightly than the parent...
  
   — 10nM at CB₁
• JWH-199 —
• JWH-200
  JWH-200
  JWH-200 is an analgesic chemical from the aminoalkylindole family, which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is 42nM, around the same as that of THC, but its analgesic potency in vivo was higher than that of other analogues with stronger CB1 binding...
  
   — an analgesic chemical from the aminoalkylindole family, which acts as a cannabinoid receptor agonist. Its binding affinity at the CB₁ receptor is 42nM, around the same as that of THC, but interestingly, its analgesic potency in vivo was higher than that of other analogues with stronger CB₁ binding affinity in vitro, around 3 times that of THC but with less sedative effect, most likely reflecting favorable pharmacokinetic characteristics.
• JWH-203
  JWH-203
  JWH-203 is an analgesic chemical from the phenylacetylindole family, which acts as a cannabinoid agonist with approximately equal affinity at both the CB1 and CB2 receptors, having a Ki of 8.0nM at CB1 and 7.0nM at CB2...
  
   — an analgesic chemical from the phenylacetylindole family, which acts as a cannabinoid agonist with approximately equal affinity at both the CB₁ and CB₂ receptors, having a K_i of 8.0nM at CB₁ and 7.0nM at CB₂. Similar to the related 2'-methoxy compound JWH-250, JWH-203 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds, and is the most potent compound found in the phenylacetyl group.
• JWH-205 — CB₁: 124nM ± 23 CB₂: 180nM ± 9 CB₂ selectivity: 1.45x SMILES: c1ccc(cc1)cC(=O)c1c(C)n(CCCCC)c2ccccc12
• JWH-210
  JWH-210
  JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki values of 0.46nM at CB1 and 0.69nM at CB2. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a...
  
   — an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB₁ and CB₂ receptors, with K_i values of 0.46nM at CB₁ and 0.69nM at CB₂. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower K_i) at CB₁ than both its 4-methyl and 4-n-propyl homologues (JWH-122 and JWH-182 respectively), and than the 4-methoxy compound JWH-081.
• JWH-213 — a potent and fairly selective CB₂ agonist with a K_i of 0.42nM ± 0.05 at CB₂ and 1.5nM ± 0.2 at CB₁ giving it 3.6x selectivity over CB₁.
• JWH-229 — 1-methoxy-3-(1',1'-dimethylhexyl)-Δ⁸-THC, a dibenzopyran "classical" cannabinoid drug with a K_i of 4.6nM ± 2.0, it is a potent CB₂ agonist.
• JWH-234 — a cannabinoid agonist that has 2.2x selectivity for CB₂ with a K_i value of 8.4nM ± 1.8 at CB₂ and 3.8nM ± 0.6 at CB₁.
• JWH-249
  JWH-249
  JWH-249 is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 2.4x selectivity for CB1 with a Ki of 8.4nM ± 1.8 and 20nM ± 2 at CB2...
  
   — CB₁: 8.4nM ± 1.8 CB₂: 20nM ± 2 selectivity for CB₁: 2.38x
• JWH-250
  JWH-250
  JWH-250 or is an analgesic chemical from the phenylacetylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors, with a Ki of 11nM at CB1 and 33nM at CB2...
  
   — an analgesic chemical from the phenylacetylindole family, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors, with a K_i of 11nM at CB₁ and 33nM at CB₂.
• JWH-251
  JWH-251
  JWH-251 is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 5x selectivity for CB1 with a Ki of 29nM and 146nM at CB2...
  
   — (1-pentyl-3-(2-methylphenylacetyl)indole) CB₁: 29nM ± 3 CB₂: 146nM ± 36 selectivity for CB₁: 5x
• JWH-253 —
• JWH-258 — a potent and mildly selective CB₁ agonist with a K_i of 4.6nM ± 0.6 and 10.5nM ± 1.3 at CB₂.
• JWH-300 —
• JWH-302
  JWH-302
  JWH-302 or is an analgesic chemical from the phenylacetylindole family, which acts as a cannabinoid agonist with moderate affinity at both the CB1 and CB2 receptors. It is a positional isomer of the more common drug JWH-250, though it is slightly less potent with a Ki of 17nM at CB1, compared to...
  
   — (1-pentyl-3-(3-methoxyphenylacetyl)indole) CB₁: 17nM ± 2 CB₂: 89nM ± 15 selectivity for CB₁: 5.26x
• JWH-307
  JWH-307
  JWH-307 is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is somewhat selective for the CB2 subtype, with a Ki of 7.7nM at CB1 vs 3.3nM at CB2. It was discovered by, and named after, Dr. John W. Huffman....
  
   — an analgesic drug from the naphthoylpyrrole family, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors. It is somewhat selective for the CB₂ subtype, with a K_i of 7.7nM at CB₁ vs 3.3nM at CB₂.
• JWH-336 —
• JWH-350 — a 11-nor-1-methoxy-3-(1',1'-dimethylheptyl)-9α-hydroxyhexahydrocannabinol with 33-fold selectivity for the CB₂ receptor and high CB₂ receptor affinity (K_i=12nM ± 1) has the desirable combination of excellent CB₂ affinity combined with little affinity for the CB₁ receptor.
• JWH-359
  JWH-359
  JWH-359 is a dibenzopyran "classical" cannabinoid drug, which is a potent and selective CB2 receptor agonist, with a Ki of 13.0nM and selectivity of around 220x for CB2 over CB1 receptors. It is related to other dibenzopyran CB2 agonists such as JWH-133 and L-759,656 but with a chiral side chain...
  
   — a dibenzopyran "classical" cannabinoid drug with a K_i of 13.0nM and selectivity of around 220x for CB₂, it is a potent and selective CB₂ receptor agonist.
• JWH-387 — 1-pentyl-3-(4-bromo-1-naphthoyl)indole
• JWH-398
  JWH-398
  JWH-398 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It has mild selectivity for CB1 with a Ki of 2.3nM and 2.8nM at CB2. It was identified by the EMCDDA as an ingredient in three separate "herbal incense" products...
  
   — an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both receptors with a K_i of 2.3nM at CB₁ and 2.8nM at CB₂.
• JWH-424
  JWH-424
  JWH-424 is a drug from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors, but with moderate selectivity for CB2, having a Ki of 5.44nM at CB2 vs 20.9nM at CB1. The heavier 8-iodo analogue is even more CB2 selective, with its 2-methyl derivative having...
  
   — a potent and moderately selective CB₂ agonist with a K_i of 5.44nM at CB₂ and 20.9nM at CB₁.

See also

• List of AM cannabinoids
• List of HU cannabinoids
• List of CP cannabinoids