JWH-302
Encyclopedia
JWH-302 or is an analgesic
chemical from the phenylacetylindole family, which acts as a cannabinoid agonist
with moderate affinity at both the CB1 and CB2
receptors. It is a positional isomer of the more common drug JWH-250
, though it is slightly less potent with a Ki
of 17nM at CB1, compared to 11nM for JWH-250. Because of their identical molecular weight and similar fragmentation patterns, JWH-302 and JWH-250 can be very difficult to distinguish by GCMS testing.
Analgesic
An analgesic is any member of the group of drugs used to relieve pain . The word analgesic derives from Greek an- and algos ....
chemical from the phenylacetylindole family, which acts as a cannabinoid agonist
Agonist
An agonist is a chemical that binds to a receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance...
with moderate affinity at both the CB1 and CB2
Cannabinoid receptor 2 (macrophage)
Cannabinoid receptor 2 , also known as CB2 or CNR2, is a G protein-coupled receptor from the cannabinoid receptor family, which in humans is encoded by the CNR2 gene...
receptors. It is a positional isomer of the more common drug JWH-250
JWH-250
JWH-250 or is an analgesic chemical from the phenylacetylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors, with a Ki of 11nM at CB1 and 33nM at CB2...
, though it is slightly less potent with a Ki
Dissociation constant
In chemistry, biochemistry, and pharmacology, a dissociation constant is a specific type of equilibrium constant that measures the propensity of a larger object to separate reversibly into smaller components, as when a complex falls apart into its component molecules, or when a salt splits up into...
of 17nM at CB1, compared to 11nM for JWH-250. Because of their identical molecular weight and similar fragmentation patterns, JWH-302 and JWH-250 can be very difficult to distinguish by GCMS testing.