ANG1005
Encyclopedia
ANG1005 is a drug candidate engineered to cross the blood brain barrier to deliver chemotherapy
for the treatment of glioma
.
It is made up of one molecule of a peptide
called Angiopep-2 joined together with three molecules of Paclitaxel
, a taxane-chemotherapy drug. It reduced tumour growth in mice and rats with glioblastoma tumors.
It targets lipoprotein receptor-related protein
(LRP-1) which is upregulated in some cancers.
In 2008 two Phase-I clinical trials of ANG1005 were started ; one in patients with advanced cancer and brain metastases, and another in patients with recurrent malignant glioma
. Favourable initial tolerability results in brain cancer were reported in March 2009. and more in October 2009 and updated in June 2010.
Chemotherapy
Chemotherapy is the treatment of cancer with an antineoplastic drug or with a combination of such drugs into a standardized treatment regimen....
for the treatment of glioma
Glioma
A glioma is a type of tumor that starts in the brain or spine. It is called a glioma because it arises from glial cells. The most common site of gliomas is the brain.-By type of cell:...
.
It is made up of one molecule of a peptide
Peptide
Peptides are short polymers of amino acid monomers linked by peptide bonds. They are distinguished from proteins on the basis of size, typically containing less than 50 monomer units. The shortest peptides are dipeptides, consisting of two amino acids joined by a single peptide bond...
called Angiopep-2 joined together with three molecules of Paclitaxel
Paclitaxel
Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a U.S. National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it taxol...
, a taxane-chemotherapy drug. It reduced tumour growth in mice and rats with glioblastoma tumors.
It targets lipoprotein receptor-related protein
LRP1
Low density lipoprotein receptor-related protein 1 , also known as alpha-2-macroglobulin receptor , apolipoprotein E receptor or cluster of differentiation 91 , is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis...
(LRP-1) which is upregulated in some cancers.
In 2008 two Phase-I clinical trials of ANG1005 were started ; one in patients with advanced cancer and brain metastases, and another in patients with recurrent malignant glioma
Glioma
A glioma is a type of tumor that starts in the brain or spine. It is called a glioma because it arises from glial cells. The most common site of gliomas is the brain.-By type of cell:...
. Favourable initial tolerability results in brain cancer were reported in March 2009. and more in October 2009 and updated in June 2010.