Acanthosis
Encyclopedia
Acanthosis is diffuse epidermal hyperplasia
Hyperplasia
Hyperplasia means increase in number of cells/proliferation of cells. It may result in the gross enlargement of an organ and the term is sometimes mixed with benign neoplasia/ benign tumor....

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Acanthosis implies increased thickness of stratum spinosum
Stratum spinosum
The stratum spinosum is a layer of the epidermis found between the stratum granulosum and stratum basale. This layer is also referred to as the "spinous" or "prickle-cell" layer. This appearance is due to desmosomal connections of adjacent cells. Keratinization begins in the stratum spinosum....

. It is a disease of
the prickle cell layer of the skin, where warts appear on the skin or inside the mouth.
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