Anti-interleukin-6 agents are a recent class of therapeutics.

Interleukin-6 is relevant to many inflammatory diseases and many cancers. Hence anti-IL-6 agents have been sought.
The first approved, tocilizumab

Tocilizumab

Tocilizumab is an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis and systemic juvenile idiopathic arthritis, a severe form of RA in children. It is a humanized monoclonal antibody against the interleukin-6 receptor...

 (Actemra), actually acts against the IL-6 receptor.

In clinical trials : Elsilimomab

Elsilimomab

Elsilimomab is a mouse monoclonal antibody and an immunosuppressive drug.It targets Interleukin-6.It has undergone a number of early stage clinical trails, eg. for lymphoma and myeloma....

 for some cancers, Anti-IL-6 chimeric monoclonal antibody

Anti-IL-6 chimeric monoclonal antibody

CNTO 328 is a chimeric monoclonal antibody being studied in the treatment of advanced kidney cancer and other types of cancer....

 (CNTO 328), ALD518

ALD518

BMS-945429 is an aglycosylated, humanized monoclonal antibody against interleukin-6. It is an investigational drug for cancer and rheumatoid arthritis due to its anti-inflammatory properties....

, CNTO 136, CPSI-2364, CDP6038.

Pre-clinical : VX30 for rheumatoid arthritis

Rheumatoid arthritis

Rheumatoid arthritis is a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks synovial joints. The process produces an inflammatory response of the synovium secondary to hyperplasia of synovial cells, excess synovial fluid, and the development...

. Also ARGX-109, FE301,
FM101

Food/diet

It has been reported that lunasin, a soy peptide, reduces inflammation by reducing interleukin-6 and may help in leukemia

Leukemia

Leukemia or leukaemia is a type of cancer of the blood or bone marrow characterized by an abnormal increase of immature white blood cells called "blasts". Leukemia is a broad term covering a spectrum of diseases...

.

Luteolin

Luteolin

Luteolin is a yellow crystalline compound. It is a flavonoid; to be specific, it is one of the more common flavones. From preliminary research, it is thought to play a role in the human body possibly as an antioxidant, a free radical scavenger, a promoter of carbohydrate metabolism, or an immune...

reduces IL-6 production in some neurons.