Arkansas Highway 121
Encyclopedia
Arkansas Highway 121 is a designation for two state highways in Lee County, Arkansas. One route of 9.49 miles (15.3 km) runs from the St. Francis River
St. Francis River
The Saint Francis River is a tributary of the Mississippi River, about long, in southeastern Missouri and northeastern Arkansas in the United States...

 to US Route 79 (US 79) northeast of Marianna
Marianna, Arkansas
Marianna is a city in and the county seat of Lee County, Arkansas, United States, along the L'Anguille River. The community was established by Col. Walter H. Otey in 1848 and was known as Walnut Ridge until 1852 when it became known as Marianna...

. A second routing begins north of Marianna at Highway 1
Arkansas Highway 1
Arkansas Highway 1 is a north–south state highway in east Arkansas. The route of runs from McGehee to Clay County and the Missouri state line. One of the original 1926 state highways, Highway 1 has remained very close to its original routing. The highway contains an overlap of approximately with...

 and runs essentially in a half-loop counterclockwise to LaGrange
LaGrange, Arkansas
LaGrange is a town in Lee County, Arkansas, United States. The population was 122 at the 2000 census.-Geography:LaGrange is located at ....

.

St. Francis River to US 79

Highway 122 begins at Lee County Route 513 at the shore of the St. Francis River
St. Francis River
The Saint Francis River is a tributary of the Mississippi River, about long, in southeastern Missouri and northeastern Arkansas in the United States...

 about 4 miles (6.4 km) west of the Mississippi River
Mississippi River
The Mississippi River is the largest river system in North America. Flowing entirely in the United States, this river rises in western Minnesota and meanders slowly southwards for to the Mississippi River Delta at the Gulf of Mexico. With its many tributaries, the Mississippi's watershed drains...

. The highway winds northwest through floodplain to terminate at US 79, which is designated as part of the Great River Road
Great River Road
The Great River Road is a collection of state, provincial, federal, and local roads which follow the course of the Mississippi River through ten states of the United States...

.

Highway 1 to LaGrange

The second portion of Highway 121 begins at Highway 1
Arkansas Highway 1
Arkansas Highway 1 is a north–south state highway in east Arkansas. The route of runs from McGehee to Clay County and the Missouri state line. One of the original 1926 state highways, Highway 1 has remained very close to its original routing. The highway contains an overlap of approximately with...

 north of Marianna
Marianna, Arkansas
Marianna is a city in and the county seat of Lee County, Arkansas, United States, along the L'Anguille River. The community was established by Col. Walter H. Otey in 1848 and was known as Walnut Ridge until 1852 when it became known as Marianna...

 and runs west through farmland. Highway 121 has a junction with Highway 261
Arkansas Highway 261
Highway 261 is a north–south highway in Arkansas running from AR 1 in Caldwell south to AR 259.-Route description:The route begins in Caldwell at AR 1 and travels southwest past Slonikers Mill to Palestine. At Palestine, AR 261 crosses I-40/US 63 and US 70. The route continues south until it...

 at Holub, after which Highway 121 turns due south. The route continues south to US 79 at Smith Corner when the two routes overlap for approximately 0.5 mile (0.80467 km) at which time Highway 121 turns south again.

After running south through a few miles of farmland the route enters Aubrey
Aubrey, Arkansas
Aubrey is a town in Lee County, Arkansas, United States. The population was 221 at the 2000 census.-Geography:Aubrey is located at ....

 as Main Street and intersects Highway 78. At Big Creek Corner the route curves east after a junction with Highway 243. Now entering Rondo
Rondo, Arkansas
Rondo is a town in Lee County, Arkansas, United States. The population was 237 at the 2000 census.-Geography:Rondo is located at ....

 the route has junction with Highway 243 (Main Street) and serves as the western terminus for Highway 316. The route continues approximately 5 miles (8 km) further east to intersect Highway 1 before it terminates at Young Boulevard in LaGrange
LaGrange, Arkansas
LaGrange is a town in Lee County, Arkansas, United States. The population was 122 at the 2000 census.-Geography:LaGrange is located at ....

.

Traffic counts from the Arkansas State Highway and Transportation Department
Arkansas State Highway and Transportation Department
The Arkansas State Highway and Transportation Department is a government department in the U.S. state of Arkansas. Its mission is to provide a safe, efficient, aesthetically pleasing and environmentally sound intermodal transportation system for the user...

(AHTD) reveal that less than 200 vehicles per day (VPD) used Highway 121 from the St. Francis River to US 79 in 2010. The semi-circular rural portion from Highway 1 to LaGrange varies between 350–950 VPD.

Major intersections

Mile markers reset at concurrencies.
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| align=center colspan=4 | Highway 121 begins at Highway 1
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| colspan=4 align=center | concurrency east, 0.5 mile (0.80467 km)
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