Arnold Klein
Encyclopedia
Arnold William "Arnie" Klein (born February 27, 1945) is an American
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...

 dermatologist and Professor of Medicine/Dermatology at the David Geffen School of Medicine at UCLA
David Geffen School of Medicine at UCLA
UCLA School of Medicine or David Geffen School of Medicine at UCLA is an accredited medical school located in Los Angeles, California, United States...

 in Los Angeles, California
Los Angeles, California
Los Angeles , with a population at the 2010 United States Census of 3,792,621, is the most populous city in California, USA and the second most populous in the United States, after New York City. It has an area of , and is located in Southern California...

.

Background and Education

Klein was born in Mt. Clemens, Michigan, the son of a Jewish Orthodox rabbi, and raised in Michigan and North Miami, Florida
North Miami, Florida
North Miami is a suburban city located in northeast Miami-Dade County, Florida, United States, about north of Miami. The city lies on Biscayne Bay and hosts the Biscayne Bay Campus of Florida International University, and the North Miami campus of Johnson & Wales University...

. He graduated from North Miami Sr. High in 1963, obtained a BA in biology from the University of Pennsylvania
University of Pennsylvania
The University of Pennsylvania is a private, Ivy League university located in Philadelphia, Pennsylvania, United States. Penn is the fourth-oldest institution of higher education in the United States,Penn is the fourth-oldest using the founding dates claimed by each institution...

 in 1967, and his MD from the University of Pennsylvania School of Medicine
University of Pennsylvania School of Medicine
The Perelman School of Medicine , formerly the University of Pennsylvania School of Medicine, was founded in 1765, making it the oldest American medical school. As part of the University of Pennsylvania, it is located in the University City section of Philadelphia, Pennsylvania. It is widely...

 in 1971. He worked as a medical intern at Cedars-Sinai Medical Center
Cedars-Sinai Medical Center
Originally established as Kaspare Cohn Hospital in 1902, Cedars-Sinai Medical Center is a non-profit, tertiary 958-bed hospital and multi-specialty academic health science centre located in Los Angeles, California, US. Part of the Cedars-Sinai Health System, the hospital employs a staff of over...

 in Los Angeles and as a resident in dermatology at the university hospitals of the University of Pennsylvania and the University of California at Los Angeles, where he worked as Chief Resident in Dermatology in 1975.

Career

Dr. Arnold Klein is considered the father of modern cosmetic dermatology and has been in the forefront of the latest treatments in this field. He developed the gold standard for minimally invasive injection techniques for physical enhancements such as Botox, Collagen
Collagen
Collagen is a group of naturally occurring proteins found in animals, especially in the flesh and connective tissues of mammals. It is the main component of connective tissue, and is the most abundant protein in mammals, making up about 25% to 35% of the whole-body protein content...

 and Restylane
Restylane
Restylane is the trade name for a range of injectable fillers with a specific formulation of non-animal sourced hyaluronic acid . Restylane was the first stabilized hyaluronic acid filler on the market and reportedly has been used in over 11 million treatments worldwide .In the United States,...

. These techniques are used worldwide by dermatologist and plastic surgeons. In 1984, Klein developed lip augmentation which to date, is the largest filler procedure used worldwide. Developing the injection techniques for Bovine collagen for wrinkles and scars helped get FDA approval and launched the highly profitable field of minimally invasive aesthetic enhancements. This discovery enabled him to speak internationally and led to his work as an advisor, consultant, and/or principal investigator for Allergan, Anike, Elan Pharmaceuticals, Ethicon, Genzyme, Johnson & Johnson, Medicis Aesthetics, Ortho-Neutrogena, Skin Medica and Q-Med. For this work he received multiple awards including, the first annual Allergan Award for Aesthetic Achievements, Allergan Award for Pioneering Work in Soft Tissue Augmentation and the American Dermatologic Association Honor Society.

Klein is an outspoken critic of the misuse of prescription drug
Prescription drug
A prescription medication is a licensed medicine that is regulated by legislation to require a medical prescription before it can be obtained. The term is used to distinguish it from over-the-counter drugs which can be obtained without a prescription...

s, and of certain synthetic dermal fillers, including ArteFill
ArteFill
Artefill is a non-resorbable injectable dermal filler for the correction of wrinkles and lines on the face. Artefill is approved by the U.S. Food and Drug Administration for correctıng smile lines but it is widely used "off label" by physicıans to fill lines and wrinkles all over the face...

. Dr. Klein was responsible for the FDA giving Allergan's Botox a black box warning. In 2010, Klein was named a consultant to the FDA.

He estimated in 2002 that he had administered Botox injections to 90,000 people, including Carrie Fisher
Carrie Fisher
Carrie Frances Fisher is an American actress, novelist, screenwriter, and lecturer. She is most famous for her portrayal of Princess Leia in the original Star Wars trilogy, her bestselling novel Postcards from the Edge, for which she wrote the screenplay to the film of the same name, and her...

, Cher
Cher
Cher is an American recording artist, television personality, actress, director, record producer and philanthropist. Referred to as the Goddess of Pop, she has won an Academy Award, a Grammy Award, an Emmy Award, three Golden Globes and a Cannes Film Festival Award among others for her work in...

, Elizabeth Taylor
Elizabeth Taylor
Dame Elizabeth Rosemond "Liz" Taylor, DBE was a British-American actress. From her early years as a child star with MGM, she became one of the great screen actresses of Hollywood's Golden Age...

 and Dolly Parton
Dolly Parton
Dolly Rebecca Parton is an American singer-songwriter, author, multi-instrumentalist, actress and philanthropist, best known for her work in country music. Dolly Parton has appeared in movies like 9 to 5, The Best Little Whorehouse in Texas, Steel Magnolias and Straight Talk...

. "Dr. Arnold Klein is acknowledged worldwide as the best! All doctors I know say the same." - Angelika Taschen, Editor of Aesthetic Surgery. People Magazine's Oscar Power 2006 issue called Dr. Klein "The Go To Guy for Botox". Klein was Michael Jackson
Michael Jackson
Michael Joseph Jackson was an American recording artist, entertainer, and businessman. Referred to as the King of Pop, or by his initials MJ, Jackson is recognized as the most successful entertainer of all time by Guinness World Records...

's dermatologist from 1985 onward, during which he diagnosed and treated Jackson for lupus
Lupus erythematosus
Lupus erythematosus is a category for a collection of diseases with similar underlying problems with immunity . Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood cells, heart, and lungs...

 and vitiligo
Vitiligo
Vitiligo is a condition that causes depigmentation of sections of skin. It occurs when melanocytes, the cells responsible for skin pigmentation, die or are unable to function. The cause of vitiligo is unknown, but research suggests that it may arise from autoimmune, genetic, oxidative stress,...

, and worked to mitigate the effects of excessive plastic surgery
Plastic surgery
Plastic surgery is a medical specialty concerned with the correction or restoration of form and function. Though cosmetic or aesthetic surgery is the best-known kind of plastic surgery, most plastic surgery is not cosmetic: plastic surgery includes many types of reconstructive surgery, hand...

. He also admonished Jackson about his use of propofol
Propofol
Propofol is a short-acting, intravenously administered hypnotic agent. Its uses include the induction and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation. Propofol is also commonly used in veterinary medicine...

 as a sleep aid.

Philanthropy

In the infancy of the AIDS
AIDS
Acquired immune deficiency syndrome or acquired immunodeficiency syndrome is a disease of the human immune system caused by the human immunodeficiency virus...

 epidemic, Dr. Klein became one of the first doctors in Los Angeles to diagnose a case of Kaposi’s sarcoma in young patients. Ever since, he has been dedicated to seeking out the best possible care for his patients. In 1985, Dr. Arnold Klein along with one of his oldest and dearest friends Dame Elizabeth Taylor
Elizabeth Taylor
Dame Elizabeth Rosemond "Liz" Taylor, DBE was a British-American actress. From her early years as a child star with MGM, she became one of the great screen actresses of Hollywood's Golden Age...

 helped bring amfAR
AmfAR
amfAR, The Foundation for AIDS Research, is an international nonprofit organization dedicated to the support of AIDS research, HIV prevention, treatment education, and the advocacy of sound AIDS-related public policy.-History:...

, the American Foundation for AIDS Research, into existence, in the living room of Klein’s home. Over the next two decades, they would both found other, allied organizations—the Elizabeth Taylor AIDS Foundation, and Klein’s Art for AIDS in Orange County—but their commitment to amfAR never wavered, and to this day both sit on its board. amfAR has invested more than $307-million in support of its mission.
Additionally, Dr. Klein founded The Elizabeth Taylor Endowment for the UCLA CARE Center in 2007, a renowned facility for HIV/AIDS research and treatment. In the November 2008 issue of L'Uomo Vogue, in an article related to AIDS in Africa, it was reported that Dr. Klein and the organizations he founded have raised in excess of $274-million for HIV research and care.
Dr. Klein serves as a trustee to various boards of directors. Some of which include the Jennifer Jones-Simon Foundation and The Hereditary Disease Foundation
Hereditary Disease Foundation
The Hereditary Disease Foundation aims to cure genetic disorders by supporting basic biomedical research.-History:In 1968, after experiencing Huntington's disease in his wife's family, Dr. Milton Wexler was inspired to start the Hereditary Disease Foundation, with the aim of curing genetic...

. Dr. Klein, alongside his old friend Frank Gehry
Frank Gehry
Frank Owen Gehry, is a Canadian American Pritzker Prize-winning architect based in Los Angeles, California.His buildings, including his private residence, have become tourist attractions...

, help the foundation to raise funds and awareness for inherited diseases.
Dr. Klein also co-founded the Rose Tarlow-Arnold W. Klein Breast Cancer Foundation at UCLA which provides breast cancer treatment for individuals who are unable to afford it.

Honors and Awards

The UCLA Division of Dermatology announced on July 23, 2004 the creation of a new endowed chair: The Arnold Klein, M.D., Chair in Dermatology. The holder of this new chair, which is the first of its kind in the dermatology division, will help promote the rapid application of basic science and clinical research discoveries to the development of new therapies in dermatology. Friends and associates of Dr. Arnold Klein have established the chair in his honor. Funding will be used to support teaching, research and pilot projects in the UCLA Division of Dermatology at the David Geffen School of Medicine at UCLA. The endowment will help foster optimum care for patients and enhance training opportunities for medical students and fellows.

He has received numerous awards and honors including Who's Who in the World, Best Doctors in America, Men of Achievement, AIDS Services Foundation of Orange County, Award of Merit, Los Angeles Magazine, The Best of L.A. Los Angeles Business Journal, 10 Masters of Medicine in Los Angeles, Haney Scholar, University of Pennsylvania, Inaugural Visiting Professor in Cosmetic Dermatology, Harvard School of Medicine, Inaugural Visiting Professor in Cosmetic Dermatology, University of Vermont, Measey Scholar, University of Pennsylvania, Philadelphia Foundation Fellow, Public Health Service Post – Doctoral Fellow, and Top Doctors of America

Publications

Dr Klein has published more than 150 scientific papers. Some of these include:

Klein AW, Cuskey W, Krassner W; Drug Trip Abroad - American Addicts in Amsterdam and London; Philadelphia, Pennsylvania; University of Pennsylvania Press; 1972

Klein AW, Samitz M. Nickel; Dermatitis: hazards from prosthesis; Journal of the American Medical Association; 1973;223:27

Klein AW, Sternberg J, Bernstein P; The Skin Book; New York, NY; MacMillan; 1980

Klein AW; Implantation techniques for injectable collagen: Two and one-half years of personal clinical experience; Journal of the American Academy of Dermatology; 1983;9(2):224–228

Kalter S. (Klein A. - Consultant); Looking Up: The Complete Guide to Looking And Feeling Good For The Recovering Cancer Patient; New York, NY; McGraw-Hill; 1987

Klein AW; Injectable Collagen: in Textbook of Dermatology, 3rd ed; Moeschella S, Hurley H, eds.; Philadelphia, Pennsylvania: W.D. Saunders; 1992

Klein AW; Substances for soft-tissue augmentation; In: Burgdorf WHC, Katz SI, eds.; Dermatology Progress and Perspectives: The Proceedings of the 18th World Congress of Dermatology; New York, NY: Parthenon Publishing Group; 1993

Klein AW; Sterility of refrigerated injectable collagen syringe; Journal of the American Academy of Dermatology; 1993;29(3):507

Klein AW; Soft-tissue augmentation in the practice of dermatology; In: Moy R, Lask G, eds.; Surgical Dermatology; New York, NY; McGraw-Hill; 1996

Klein AW; Injectable collagen: a tutorial; In: Dzubow L M.D. ed.; Cosmetic Dermatologic Surgery; Lippincott-Raven Publishers; 1998

Klein AW; Tissue Augmentation in Clinical Practice: Procedures and Techniques Textbook; Shalita AR M.D., Norris AD M.D., eds.; New York, NY; Marcel Dekker, Inc.; 1998

Klein AW; Substances for soft tissue augmentation; In: Freedberg I M.D., ed.; Fitzpatrick’s Dermatology in General Medicine, 5th ed.; New York, NY; McGraw Hill;1999

Klein AW, Klein J, Narins R; Tumescent liposuction; In: Freedberg I M.D., ed.; Fitzpatrick’s Dermatology in General Medicine, 5th ed.; Vol II; New York, NY; McGraw Hill; 1999

Klein AW; Injectable augmentation (fat, collagen); In: Blitzer A M.D., Binder WJ M.D., Boyd JB M.D., Carruthers A M.D., eds.; Management of facial lines and wrinkles; Lippincott, Williams and Wilkins Publishers; 2000:145-176

Klein AW; Filling substances: collagen; In: Narins R M.D., ed.; Cosmetic Surgery: An Interdisciplinary Approach; Marcel Dekker, Inc. Publishers; 2001:193-220

Klein AW; New filling substances on the horizon; In: Narins R M.D., ed.; Cosmetic Surgery: An Interdisciplinary Approach; Marcel Dekker, Inc. Publishers; 2001:313-331

Klein AW; Treatment of wrinkles with botox (forehead, glabella, crow-feet, mental); In: Kreydon OP, Böni R M.D., Burg G, eds.; Hyperhidrosis and botulinum toxin in dermatology; Current Problems in Dermatology; Basel, Krager Publishers 2002; 30:188-217

Klein AW, Krauss M,; Soft tissue augmentation; In: Kaminer M, Dover J, Arndt K, eds.; Atlas of Cosmetic Surgery; WB Saunders Company, Publishers; 2002:264-290

Klein AW, Kreyden OP; Storage and dilution of botulinum toxin; In: Boni R, Burg G, Kreyden OP, eds.; Hyperhidrosis and Botulinum Toxin in Dermatology; S. Karger Publishers; 2002;30:126-130

Klein AW, Carruthers J M.D., Carruthers A M.D., Lowe NJ M.D., et al.; A multicenter, double-blind, randomized, placebo-controlled study of the efficacy and safety of botulinum toxin type A in the treatment of glabellar lines; Journal of the American Academy of Dermatology; 2002 :46:840-849

Klein AW; Treatment of migraine: letter to the editor; New England Journal of Medicine; Sept 5th 2002;347(10):764-766

Klein AW; Temporary dermal fillers usa; In: Lowe NJ, ed.; Textbook of Facial Rejuvenation: The Art of Minimally Invasive Combination Therapy; Martin Dunitz Publishers 2003;17:189-202

Klein AW; Substances for soft tissue augmentation; In Freedberg I M.D., ed.; Fitzpatrick’s Dermatology in General Medicine, 6th ed. New York, NY; McGraw Hill; 2003

Klein AW, Klein J, Narins, R; Tumescent liposuction; In: Freedberg I M.D., ed.; Fitzpatrick’s Dermatology in General Medicine, 6th ed. Volume II; New York, NY; McGraw Hill; 2003

Klein AW; Temporary fillers; In: Nouri K M.D., Leal-Khouri S M.D., eds.; Techniques in Dermatologic Surgery, Edinburgh, London; Mosby; 2003

Klein, AW; Treatment of dyshidrotic hand dermatitis with intradermal botulinum; Letter to the Editor; Journal of the American Academy of Dermatology; Jan 2004; 4 (1)

Klein AW; Tissue Augmentation in Clinical Practice; Textbook, Second Ed., Taylor & Francis; January, 2006

Klein AW, Alam M, DesJardin J, et al.; A quality rating scale for aesthetic surgical procedures; Journal of the American Academy of Dermatology; 2006; 54(2): 272-282

External links

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