Atul Kumar
Encyclopedia
Atul Kumar [ अतुल कुमार् ] (Born, April 28, 1963, Lucknow, India
) is a scientist in the Central Drug Research Institute
of Lucknow
, India
.
His areas of research are organic chemistry, medicinal chemistry
and drug design. He has made significant contributions to research on osteoporosis
, cancer
, Tuberculosis
, diabetes and other metabolic disorders. He also has considerable contributions in the area of organic chemistry particularly in the development of organocatalysed synthesis, Biomimetic synthesis, Multicomponent Reaction, Green Chemistry, Sonochemistry, Enzymatic synthesis, and Diversity Oriented synthesis, Functional Ionic Liquid Mediated Synthesis (FILMS).
.
He is working as a Principal scientist (Scfaculty member) in the department of Medicinal Chemistry at the Central Drug Research Institute
in Lucknow, India.
He has developed a new drug candidates “CENTHANK” CDRI-99-373,(anti-resorptive agent)for the treatment of osteoporosis which is currently in Phase I clinical trial
s, diabetes and breast cancer, which are in preclinical stages.
In the area of organic synthesis, he has been involved in the development of new catalysts such as Liposomised mCPBA (LIP-mCPBA), new solid-supported hypervalent iodine
reagents, and the use of human hemoglobin
(HbA) and supramolecular carbohydrate
molecules as solid catalysts for the synthesis of bioactive molecules. He has extensively contributed to the development of organocatalysed synthesis, biomimetic synthesis, multicomponent reaction, sonochemistry, enzymatic synthesis, high-throughput synthesis and diversity oriented synthesis.
Dr. Kumar was the first to demonstrate that single nucleotides have the ability to catalyze organic reactions, and performed Biomimetic reductive amination, which is considered as one of the most genuine biomimetic reactions of organic chemistry. This single-nucleotide
catalysis has immense impact on many fields of science such as chemistry, biochemistry, and prebiotic studies, especially the RNA world and DNA world hypothesis for understanding the origin of life on Earth.
Dr. Kumar has recently demonstrated a new protocol for organic synthesis involving Functional Ionic Liquids and named this new methodology as Functional Ionic Liquid Mediated Synthesis (FILMS).
These studies have resulted in publication of about 65 original research papers, and 42 patents.
& anti cancer.The discovery of anti-osteoporosis agent CDRI-99-373, this drug was also recognized as a "notable Science and technological achievement" by the Government of India Planning Commission in its ``Report of Steering Committee of Science and Technology for eleventh Five year plan (2007-2012).
He has received several honors and awards, notably the Organization of Pharmaceutical Producers of India (OPPI) OPPI SCIENTIST AWARD 2007. This award is given by Mr. Ram Vilas Paswan, Hon. Minster for Chemical and Fertilizers, Government of India at Mumbai,
including R
1,00,000.00 as a cash award. He also received CDRI Incentive Awards for years 2004, 2005, 2006, 2007, 2008,2009,2010 and 2011.
Several of his publications in synthetic chemistry and medicinal chemistry have been recognized as distinguish research contributions:
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India
India , officially the Republic of India , is a country in South Asia. It is the seventh-largest country by geographical area, the second-most populous country with over 1.2 billion people, and the most populous democracy in the world...
) is a scientist in the Central Drug Research Institute
Central Drug Research Institute
The Central Drug Research Institute is one of the first laboratories to be established in India right after its independence. CDRI is among the thirty nine laboratories that are functioning under the aegis of the council of scientific and Industrial Research CSIR of India...
of Lucknow
Lucknow
Lucknow is the capital city of Uttar Pradesh in India. Lucknow is the administrative headquarters of Lucknow District and Lucknow Division....
, India
India
India , officially the Republic of India , is a country in South Asia. It is the seventh-largest country by geographical area, the second-most populous country with over 1.2 billion people, and the most populous democracy in the world...
.
His areas of research are organic chemistry, medicinal chemistry
Medicinal chemistry
Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where it is involved with design, chemical synthesis and development for market of pharmaceutical...
and drug design. He has made significant contributions to research on osteoporosis
Osteoporosis
Osteoporosis is a disease of bones that leads to an increased risk of fracture. In osteoporosis the bone mineral density is reduced, bone microarchitecture is deteriorating, and the amount and variety of proteins in bone is altered...
, cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
, Tuberculosis
Tuberculosis
Tuberculosis, MTB, or TB is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. Tuberculosis usually attacks the lungs but can also affect other parts of the body...
, diabetes and other metabolic disorders. He also has considerable contributions in the area of organic chemistry particularly in the development of organocatalysed synthesis, Biomimetic synthesis, Multicomponent Reaction, Green Chemistry, Sonochemistry, Enzymatic synthesis, and Diversity Oriented synthesis, Functional Ionic Liquid Mediated Synthesis (FILMS).
Education & Profession
Atul Kumar obtained his masters degree and Ph.D from Lucknow University, then worked as a post-doc at the SUNY BuffaloUniversity at Buffalo, The State University of New York
University at Buffalo, The State University of New York, also commonly known as the University at Buffalo or UB, is a public research university and a "University Center" in the State University of New York system. The university was founded by Millard Fillmore in 1846. UB has multiple campuses...
.
He is working as a Principal scientist (Scfaculty member) in the department of Medicinal Chemistry at the Central Drug Research Institute
Central Drug Research Institute
The Central Drug Research Institute is one of the first laboratories to be established in India right after its independence. CDRI is among the thirty nine laboratories that are functioning under the aegis of the council of scientific and Industrial Research CSIR of India...
in Lucknow, India.
He has developed a new drug candidates “CENTHANK” CDRI-99-373,(anti-resorptive agent)for the treatment of osteoporosis which is currently in Phase I clinical trial
Clinical trial
Clinical trials are a set of procedures in medical research and drug development that are conducted to allow safety and efficacy data to be collected for health interventions...
s, diabetes and breast cancer, which are in preclinical stages.
In the area of organic synthesis, he has been involved in the development of new catalysts such as Liposomised mCPBA (LIP-mCPBA), new solid-supported hypervalent iodine
Iodine
Iodine is a chemical element with the symbol I and atomic number 53. The name is pronounced , , or . The name is from the , meaning violet or purple, due to the color of elemental iodine vapor....
reagents, and the use of human hemoglobin
Hemoglobin
Hemoglobin is the iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates, with the exception of the fish family Channichthyidae, as well as the tissues of some invertebrates...
(HbA) and supramolecular carbohydrate
Carbohydrate
A carbohydrate is an organic compound with the empirical formula ; that is, consists only of carbon, hydrogen, and oxygen, with a hydrogen:oxygen atom ratio of 2:1 . However, there are exceptions to this. One common example would be deoxyribose, a component of DNA, which has the empirical...
molecules as solid catalysts for the synthesis of bioactive molecules. He has extensively contributed to the development of organocatalysed synthesis, biomimetic synthesis, multicomponent reaction, sonochemistry, enzymatic synthesis, high-throughput synthesis and diversity oriented synthesis.
Dr. Kumar was the first to demonstrate that single nucleotides have the ability to catalyze organic reactions, and performed Biomimetic reductive amination, which is considered as one of the most genuine biomimetic reactions of organic chemistry. This single-nucleotide
Nucleotide
Nucleotides are molecules that, when joined together, make up the structural units of RNA and DNA. In addition, nucleotides participate in cellular signaling , and are incorporated into important cofactors of enzymatic reactions...
catalysis has immense impact on many fields of science such as chemistry, biochemistry, and prebiotic studies, especially the RNA world and DNA world hypothesis for understanding the origin of life on Earth.
Dr. Kumar has recently demonstrated a new protocol for organic synthesis involving Functional Ionic Liquids and named this new methodology as Functional Ionic Liquid Mediated Synthesis (FILMS).
These studies have resulted in publication of about 65 original research papers, and 42 patents.
Awards and honors
Kumar has won several awards for the design,synthesis and discovery of New Chemical Entities (NCEs) for various therapeutic areas associated with women reproductive health (osteoporosis) and metabolic diseases like diabetes& anti cancer.The discovery of anti-osteoporosis agent CDRI-99-373, this drug was also recognized as a "notable Science and technological achievement" by the Government of India Planning Commission in its ``Report of Steering Committee of Science and Technology for eleventh Five year plan (2007-2012).
He has received several honors and awards, notably the Organization of Pharmaceutical Producers of India (OPPI) OPPI SCIENTIST AWARD 2007. This award is given by Mr. Ram Vilas Paswan, Hon. Minster for Chemical and Fertilizers, Government of India at Mumbai,
including R
Rupee
The rupee is the common name for the monetary unit of account in India, Sri Lanka, Nepal, Pakistan, Mauritius, Seychelles, Maldives, and formerly in Burma, and Afghanistan. Historically, the first currency called "rupee" was introduced in the 16th century...
1,00,000.00 as a cash award. He also received CDRI Incentive Awards for years 2004, 2005, 2006, 2007, 2008,2009,2010 and 2011.
Several of his publications in synthetic chemistry and medicinal chemistry have been recognized as distinguish research contributions:
- "Synthesis of Benzimidazoles, Benzoxazoles and Benzothiazoles with PDAIS" (J. Combinatorial Chemistry, 2009) was listed as a distinguished paper in SYNFACT
- His papers published as Tetrahedron LettersTetrahedron Letters-See also:*Tetrahedron*Tetrahedron: Asymmetry...
34, 4751, 1996, Tetrahedron LettersTetrahedron Letters-See also:*Tetrahedron*Tetrahedron: Asymmetry...
37,3463, 1993 were listed in the "HEART CUT" Column of "CHEM TECH" (ACS Publication) as distinguished papers. - His work on diabetes has been cited by the "Nature” eMagazine Nature India in its Research highlights.
- His paper on the synthesis of heterocycles using aqueous micelles and ultrasonic irradiation is listed in the Organic Chemistry Portal.
- His paper " ß-cyclodextrin catalysed synthesis of Tryptanthrin " has been listed in Top ten most accessed articles of Green Chemistry.
- His paper "Single Nucleotide-Catalyzed Biomimetic Reductive Amination" has been covered by the "Nature” eMagazine Nature India in its Research highlights "Probing the origin of life".
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