BZIP domain
Encyclopedia
The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA
binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper
that is required for the dimerization of two DNA binding regions. The DNA binding region comprises a number of basic aminoacids such as arginine
and lysine
. Proteins containing this domain are transcription factors.
of all plants. Interactions between bZIP transcription factors play important role in cancer development in epithelial tissues, steroid hormone synthesis by cells of endocrine tissues, factors affecting reproductive functions, and several other phenomena that affect human health.
; ATF2; ATF4
; ATF5
; ATF6
; ATF7
; BACH1
; BACH2
;
BATF; BATF2; CREB1
; CREB3
; CREB3L1; CREB3L2; CREB3L3; CREB3L4;
CREB5
; CREBL1
; CREM; E4BP4; FOSL1
; FOSL2
; JUN
; JUNB
; JUND
; MAFA
; MAFB
;
NFE2
; NFE2L2
; NFE2L3
; SNFT; CREM
DNA
Deoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms . The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in...
binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper
Leucine zipper
A leucine zipper, aka leucine scissors, is a common three-dimensional structural motif in proteins. These motifs are usually found as part of a DNA-binding domain in various transcription factors, and are therefore involved in regulating gene expression...
that is required for the dimerization of two DNA binding regions. The DNA binding region comprises a number of basic aminoacids such as arginine
Arginine
Arginine is an α-amino acid. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that codify for arginine during...
and lysine
Lysine
Lysine is an α-amino acid with the chemical formula HO2CCH4NH2. It is an essential amino acid, which means that the human body cannot synthesize it. Its codons are AAA and AAG....
. Proteins containing this domain are transcription factors.
bZIP transcription factors
bZIP transcription factors are found in all organisms. A recent evolutionary study revealed that 4 bZIP genes were encoded by the genome of the most recent common ancestorMost recent common ancestor
In genetics, the most recent common ancestor of any set of organisms is the most recent individual from which all organisms in the group are directly descended...
of all plants. Interactions between bZIP transcription factors play important role in cancer development in epithelial tissues, steroid hormone synthesis by cells of endocrine tissues, factors affecting reproductive functions, and several other phenomena that affect human health.
bZIP domain containing proteins
- AP-1AP-1 (transcription factor)In the field of molecular biology, the activator protein 1 is a transcription factor which is a heterodimeric protein composed of proteins belonging to the c-Fos, c-Jun, ATF and JDP families. It regulates gene expression in response to a variety of stimuli, including cytokines, growth factors,...
fosC-FosIn the field of molecular biology and Genetics, c-Fos is a protein encoded by the FOS gene.-Structure and function:c-Fos is a cellular proto-oncogene belonging to the immediate early gene family of transcription factors. c-Fos has a leucine-zipper DNA binding domain, and a transactivation domain at...
/junC-junc-Jun is the name of a gene and protein that, in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the c-jun gene. It is activated through double phosphorylation by the...
heterodimer that forms a transcription factorTranscription factorIn molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA... - Jun-BJUNBTranscription factor jun-B is a protein that in humans is encoded by the JUNB gene. Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.-Interactions:JUNB has been shown...
transcription factor - CREBCREBCREB is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements , thereby increasing or decreasing the transcription of the downstream genes....
cAMP response element transcription factor - OPAQUE2 (O2) transcription factor of the 22-kD zein gene that encodes a class of storage proteins in the endospermEndospermEndosperm is the tissue produced inside the seeds of most flowering plants around the time of fertilization. It surrounds the embryo and provides nutrition in the form of starch, though it can also contain oils and protein. This makes endosperm an important source of nutrition in human diet...
of maize (Zea Mays) kernels
Human proteins containing this domain
ATF1ATF1
Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.-Interactions:ATF1 has been shown to interact with CSNK2A2, Casein kinase 2, alpha 1 and BRCA1. EWS,- External links :...
; ATF2; ATF4
ATF4
Activating transcription factor 4 , also known as ATF4, is a protein that in humans is encoded by the ATF4 gene.- Function :...
; ATF5
ATF5
Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ATF5 gene.- Function :First described by Nishizawa and Nagata, ATF5 has been classified as a member of the activating transcription factor /cAMP response-element binding protein family.ATF5...
; ATF6
ATF6
Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene and is involved in unfolded protein response.- Function :...
; ATF7
ATF7
Cyclic AMP-dependent transcription factor ATF-7 is a protein that in humans is encoded by the ATF7 gene.-Homonym:In 2001, Peters et al...
; BACH1
BACH1
Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.-Further reading:- External links :...
; BACH2
BACH2
Transcription regulator protein BACH2 is a protein that in humans is encoded by the BACH2 gene....
;
BATF; BATF2; CREB1
CREB1
CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters...
; CREB3
CREB3
Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene.-Interactions:CREB3 has been shown to interact with Host cell factor C1.- External links :...
; CREB3L1; CREB3L2; CREB3L3; CREB3L4;
CREB5
CREB5
Cyclic AMP-responsive element-binding protein 5 is a protein that in humans is encoded by the CREB5 gene.-Further reading:...
; CREBL1
CREBL1
CAMP responsive element binding protein-like 1, also known as CREBL1, is a protein which in humans is encoded by the CREBL1 gene.- Function :...
; CREM; E4BP4; FOSL1
FOSL1
Fos-related antigen 1 is a protein that in humans is encoded by the FOSL1 gene.-Interactions:FOSL1 has been shown to interact with USF1 and C-jun....
; FOSL2
FOSL2
Fos-related antigen 2 is a protein that in humans is encoded by the FOSL2 gene....
; JUN
JUN
JUN, or JUN Auto, is a Japanese tuning shop. JUN began as the research facility of Tanaka Industrial Co., Ltd. and originally focused on disassembling and improving engines. It now manufactures cars with a high level of engine performance and also manufactures car parts...
; JUNB
JUNB
Transcription factor jun-B is a protein that in humans is encoded by the JUNB gene. Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.-Interactions:JUNB has been shown...
; JUND
JunD
Transcription factor jun-D is a protein that in humans is encoded by the JUND gene.-Interactions:JunD has been shown to interact with ATF3, MEN1, DNA damage-inducible transcript 3 and BRCA1....
; MAFA
MAFA
MAFA is a type II membranal glycoprotein, first identified on the surface of rat mucosal-type mast cells of the RBL-2H3 line...
; MAFB
MAFB (gene)
Transcription factor MafB also known as V-maf musculoaponeurotic fibrosarcoma oncogene homolog B is a protein that in humans is encoded by the MAFB gene...
;
NFE2
NFE2
Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene.-Interactions:NFE2 has been shown to interact with CREB-binding protein.- External links :...
; NFE2L2
NFE2L2
Nuclear factor -like 2, also known as NFE2L2 or Nrf2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NFE2L2 induces the expression of various genes including those that encode for several antioxidant enzymes, and it may play a physiological role in the regulation of...
; NFE2L3
NFE2L3
Nuclear factor erythroid 2-related factor 3, also known as NF-E2-related factor 3 or Nrf3, is a transcription factor that in humans is encoded by the NFE2L3 gene.- Function :...
; SNFT; CREM