CD11
Encyclopedia
CD11 is the α component of various integrin
s, especially ones in which the β(beta) component is CD18 (β2) and mediate leukocyte adhesion. For example,
Integrin
Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the ECM. They also play a role in cell signaling and thereby regulate cellular shape, motility, and the cell cycle....
s, especially ones in which the β(beta) component is CD18 (β2) and mediate leukocyte adhesion. For example,
- LFA1 (CD11aCD11aIntegrin, alpha L , also known as ITGAL, is a human gene which functions in the immune system. It is involved in cellular adhesion and costimulatory signaling...
/CD18CD18Integrin beta-2 is a protein that in humans is encoded by the ITGB2 gene.It is the beta subunit of four different structures:* LFA-1 * Macrophage-1 antigen * Integrin alphaXbeta2...
) short representation of Lymphocyte Function-associated Antigen 1, also called αLβ2 integrin - Mac1 (CD11bIntegrin alpha MIntegrin alpha M is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 molecule, also known as macrophage-1 antigen or complement receptor 3 . ITGAM is also known as CR3A, and cluster of differentiation molecule 11B...
/CD18CD18Integrin beta-2 is a protein that in humans is encoded by the ITGB2 gene.It is the beta subunit of four different structures:* LFA-1 * Macrophage-1 antigen * Integrin alphaXbeta2...
) present on macrophageMacrophageMacrophages are cells produced by the differentiation of monocytes in tissues. Human macrophages are about in diameter. Monocytes and macrophages are phagocytes. Macrophages function in both non-specific defense as well as help initiate specific defense mechanisms of vertebrate animals...
s that is also called Macrophage-1 antigenMacrophage-1 antigenMacrophage-1 antigen is a complement receptor consisting of CD11b and CD18.It binds to C3b and C4b.-Function:...
(CR3) and αmβ2 integrin. - CD11cCD11cCD11c, also known as Integrin, alpha X , is a human gene.CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst;...
/CD18CD18Integrin beta-2 is a protein that in humans is encoded by the ITGB2 gene.It is the beta subunit of four different structures:* LFA-1 * Macrophage-1 antigen * Integrin alphaXbeta2...
also called complementComplement systemThe complement system helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the immune system called the innate immune system that is not adaptable and does not change over the course of an individual's lifetime...
receptor 4 (CR4)