Integrin beta-1 is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the ITGB1 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

. CD29 is an integrin

Integrin

Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the ECM. They also play a role in cell signaling and thereby regulate cellular shape, motility, and the cell cycle....

 unit associated with very late antigen receptors. It is known to conjoin with alpha-3 subunit

CD49c

Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene.ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.ITGA3...

 to create α3β1 complex that reacts to such molecules as netrin-1

NTN1

Netrin-1 is a protein that in humans is encoded by the NTN1 gene.Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development...

 and reelin

Reelin

Reelin is a large secreted extracellular matrix protein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain. It modulates the...

.

Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis

Hemostasis

Hemostasis or haemostasis is a process which causes bleeding to stop, meaning to keep blood within a damaged blood vessel . Most of the time this includes blood changing from a liquid to a solid state. Intact blood vessels are central to moderating blood's tendency to clot...

, tissue repair, immune response and metastatic diffusion of tumor cells. The protein encoded by this gene is a beta subunit. Six alternatively spliced variants have been found for this gene which encode five proteins with alternate carboxy termini.

Interactions

CD29 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with TSPAN4

TSPAN4

Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.-Interactions:TSPAN4 has been shown to interact with CD9, ITGA6, CD29, CD49c and CD81.-Further reading:...

, CD9

CD9

CD9 antigen is a protein that in humans is encoded by the CD9 gene.-Interactions:CD9 has been shown to interact with TSPAN4, PTGFRN, CD81, CD117, CD46, CD29 and CD49c.-Further reading:...

, Filamin

Filamin

Filamins are a class of proteins that hold two actin filaments at large angles.Types include:* FLNA* FLNB* FLNC...

, FLNB

FLNB

Filamin B, beta , also known as FLNB, is a human cytoplasmic protein. It regulates intracellular communication and signalling by cross-linking the protein actin to allow direct communication between the cell membrane and cytoskeletal network, to control and guide proper skeletal...

, CD81

CD81

CD81 molecule, also known as CD81 , is a protein which in humans is encoded by the CD81 gene...

, CD46

CD46

CD46 complement regulatory protein also known as CD46 and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene. CD46 is an inhibitory complement receptor.- Gene :...

, MAP4K4

MAP4K4

Mitogen-activated protein kinase kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP4K4 gene.-Interactions:MAP4K4 has been shown to interact with NCK1 and CD29.-Further reading:...

, FHL2

FHL2

Four and a half LIM domains protein 2 is a protein that in humans is encoded by the FHL2 gene.-Interactions:FHL2 has been shown to interact with Beta-catenin, Titin, Zinc finger and BTB domain-containing protein 16, Integrin, beta 6, Androgen receptor, ITGA7, CREB1, MAPK1, CD49c, ZNF638, BRCA1,...

, NME1

NME1

Nucleoside diphosphate kinase A is an enzyme that in humans is encoded by the NME1 gene. It is thought to be a metastasis suppressor.-Interactions:...

, PKC alpha

PKC alpha

Protein kinase C alpha , also known as PRKCA, refers to both a human gene and the protein that is encoded by it.-Background:...

, YWHAB

YWHAB

14-3-3 protein beta/alpha is a protein that in humans is encoded by the YWHAB gene.-Interactions:YWHAB has been shown to interact with CDC25A, CDC25B, BRAF, C-Raf, RPS6KA1, EPB41L3, CD29, Wee1-like protein kinase, PTPN3, Protein kinase Mζ, MAPK7, TESK1, TNFAIP3, Cbl gene, HDAC4 and KCNK3.-Further...

, ITGB1BP1

ITGB1BP1

Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene.-Interactions:ITGB1BP1 has been shown to interact with KRIT1, LRP2, CD29 and LRP1.-Further reading:...

, LGALS8

LGALS8

Galectin-8 is a protein that in humans is encoded by the LGALS8 gene.-Interactions:LGALS8 has been shown to interact with CD49d, CD29 and CD49c.-Further reading:...

 and GNB2L1

GNB2L1

Guanine nucleotide-binding protein subunit beta-2-like 1 is a protein that in humans is encoded by the GNB2L1 gene.-Interactions:GNB2L1 has been shown to interact with PDE4D, STAT1, Tyrosine kinase 2, Src, Androgen receptor, AGTRAP, Janus kinase 1, FYN, Cyclin A1, IFNAR2, PRKCE, P73, RAS p21...

. A neutralizing antibody for CD29 is AIIB2.

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