CSL Behring
Encyclopedia
CSL Behring is one of the world's leading plasma protein biotherapeutics companies, specializing in the manufacture of therapies for the treatment of rare and serious diseases. Its line of therapies includes products for the treatment of hemophilia, von Willebrand Disease
, and other bleeding disorders; immune deficiencies including primary immunodeficiency
diseases (PIDD); hereditary angioedema
and inherited respiratory disease. The company's products are also used in cardiac surgery, organ transplantation, burn treatment and to prevent hemolytic diseases in newborns.
The company also operates one of the world's largest plasma collection networks, CSL Plasma.
, (ASX
:CSL), Melbourne, Australia
Headquarters: King of Prussia
, PA
Employees: 9,000+
Operations: In 19 countries
President: Paul Perreault
R&D: Marburg, Germany; Bern, Switzerland; King of Prussia, Pennsylvania, USA; Tokyo, Japan; Broadmeadows and Parkville, Victoria, Australia.
CSL Behring traces its heritage back to Emil von Behring, the inventor of serum therapy or serology
.
1901: Emil von Behring was the first recipient of the Nobel Prize
in Physiology or Medicine.
1904: Emil von Behring founded the Behringwerke in Marburg, Germany, for the purpose of experimental work on disease prevention and for the manufacture of sera and vaccines.
1913: Behringwerke expands to produce a gas gangrene antiserum and a cholera vaccine.
1916: CSL (then Commonwealth Serum Laboratories) was established in Australia with the goal of providing vaccines to the people of Australia and New Zealand.
1917: CSL produces 3 million doses of a mixed bacterial vacine to combat the 1919 influenza pandemic.
1930: CSL releases its first life-saving antivenom for tiger snake bites.
1940: Armour Pharmaceuticals (a predecessor company) in Kankakee, Illinois, becomes the largest supplier of human albumin
(the most abundant protein in human blood plasma) in World War II
.
1944: CSL begins producing penicillin on a large scale for the military and Australia is the first country to supply the drug to civilians at no charge.
1949: ZLB (Zentrallaboratorium Blutspendedienst, a predecessor company) is established in Bern, Switzerland, as a department of the Swiss Red Cross
and holds its first donor blood sessions in Switzerland.
1954: Australian CSL officer Val Bazeley assists Jonas Salk
with the production of the experimental polio vaccine used in the first clinical trials in the US. Bazeley returns to Australia to set up production of the Salk vaccine at CSL.
1966: Rh(D) immunoglobulin, produced from plasma, is introduced by CSL for haemolytic disease in newborns.
1981: Behringwerke introduces Haemate® human plasma coagulation factor VIII
/von Willebrand factor
complex for the treatment of patients with hemophilia A.
1991: CSL Limited is incorporated in Australia.
2000: ZLB Bioplasma (a predecessor company) is established, acquiring the plasma fractionation assets from SRK, a nonprofit organization affiliated with the Swiss Red Cross
. ZLB becomes the fifth largest manufacturer of plasma products worldwide.
2001: Aventis Behring (a predecessor company) acquires 42 plasma centers, forming the world's largest plasma collection business.
2004: CSL Limited completes the acquisition of Aventis Behring, combining it with ZLB Bioplasma to create ZLB Behring (later CSL Behring).
2007: ZLB Behring becomes CSL Behring.
2009: ZLB Plasma changes its name to CSL Plasma to align with its parent company, CSL Behring, and opens the world's largest and most advanced plasma testing laboratories in Knoxville, Tennessee.
Immunology
:
Coagulation
/Bleeding Disorders:
Pulmonary:
Critical Care
:
Wound Healing:
(Note: Product availability varies from country to country, depending on registration status.)
. It has 9,000+ employees in 19 countries. Major manufacturing centers are located in Bern, Switzerland, Marburg, Germany
and Kankakee, Illinois
.
Von Willebrand disease
von Willebrand disease is the most common hereditary coagulation abnormality described in humans, although it can also be acquired as a result of other medical conditions. It arises from a qualitative or quantitative deficiency of von Willebrand factor , a multimeric protein that is required for...
, and other bleeding disorders; immune deficiencies including primary immunodeficiency
Primary immunodeficiency
Primary immunodeficiencies are disorders in which part of the body's immune system is missing or does not function properly. To be considered a primary immunodeficiency, the cause of the immune deficiency must not be secondary in nature...
diseases (PIDD); hereditary angioedema
Hereditary angioedema
Hereditary angioedema presents in the second to fourth decade, and is characterized by local swelling in subcutaneous tissues....
and inherited respiratory disease. The company's products are also used in cardiac surgery, organ transplantation, burn treatment and to prevent hemolytic diseases in newborns.
The company also operates one of the world's largest plasma collection networks, CSL Plasma.
Company Statistics
Parent Company: CSL LimitedCSL Limited
CSL Limited is a global specialty biopharmaceutical company that researches, develops, manufactures and markets products to treat and prevent serious human medical conditions...
, (ASX
ASX
ASX may refer to:* Australian Securities Exchange, the primary stock exchange of Australia* Advanced Stream Redirector, a computer file format listing Windows Media files * Armstrong Siddeley ASX, a British experimental turbojet* John F...
:CSL), Melbourne, Australia
Headquarters: King of Prussia
King of Prussia, Pennsylvania
King of Prussia is a census-designated place in Upper Merion Township, Montgomery County, Pennsylvania, United States. As of the 2010 census, its population was 19,936. The community took its name in the 18th century from a local tavern named the King of Prussia Inn, which was named after...
, PA
Employees: 9,000+
Operations: In 19 countries
President: Paul Perreault
R&D: Marburg, Germany; Bern, Switzerland; King of Prussia, Pennsylvania, USA; Tokyo, Japan; Broadmeadows and Parkville, Victoria, Australia.
History
CSL Behring is a subsidiary of CSL Limited (ASX: CSL), a specialty biopharmaceutical company with headquarters in Parkville, Australia. As part of a global alignment, the CSL Behring brand was established in 2007. Previously known as ZLB Behring, the company has a long history dating back to 1904.CSL Behring traces its heritage back to Emil von Behring, the inventor of serum therapy or serology
Serology
Serology is the scientific study of blood serum and other bodily fluids. In practice, the term usually refers to the diagnostic identification of antibodies in the serum...
.
1901: Emil von Behring was the first recipient of the Nobel Prize
Nobel Prize
The Nobel Prizes are annual international awards bestowed by Scandinavian committees in recognition of cultural and scientific advances. The will of the Swedish chemist Alfred Nobel, the inventor of dynamite, established the prizes in 1895...
in Physiology or Medicine.
1904: Emil von Behring founded the Behringwerke in Marburg, Germany, for the purpose of experimental work on disease prevention and for the manufacture of sera and vaccines.
1913: Behringwerke expands to produce a gas gangrene antiserum and a cholera vaccine.
1916: CSL (then Commonwealth Serum Laboratories) was established in Australia with the goal of providing vaccines to the people of Australia and New Zealand.
1917: CSL produces 3 million doses of a mixed bacterial vacine to combat the 1919 influenza pandemic.
1930: CSL releases its first life-saving antivenom for tiger snake bites.
1940: Armour Pharmaceuticals (a predecessor company) in Kankakee, Illinois, becomes the largest supplier of human albumin
Albumin
Albumin refers generally to any protein that is water soluble, which is moderately soluble in concentrated salt solutions, and experiences heat denaturation. They are commonly found in blood plasma, and are unique to other blood proteins in that they are not glycosylated...
(the most abundant protein in human blood plasma) in World War II
World War II
World War II, or the Second World War , was a global conflict lasting from 1939 to 1945, involving most of the world's nations—including all of the great powers—eventually forming two opposing military alliances: the Allies and the Axis...
.
1944: CSL begins producing penicillin on a large scale for the military and Australia is the first country to supply the drug to civilians at no charge.
1949: ZLB (Zentrallaboratorium Blutspendedienst, a predecessor company) is established in Bern, Switzerland, as a department of the Swiss Red Cross
Swiss Red Cross
The Swiss Red Cross is the national Red Cross society for Switzerland.It was founded in 1866 in Bern, Switzerland...
and holds its first donor blood sessions in Switzerland.
1954: Australian CSL officer Val Bazeley assists Jonas Salk
Jonas Salk
Jonas Edward Salk was an American medical researcher and virologist, best known for his discovery and development of the first safe and effective polio vaccine. He was born in New York City to parents from Ashkenazi Jewish Russian immigrant families...
with the production of the experimental polio vaccine used in the first clinical trials in the US. Bazeley returns to Australia to set up production of the Salk vaccine at CSL.
1966: Rh(D) immunoglobulin, produced from plasma, is introduced by CSL for haemolytic disease in newborns.
1981: Behringwerke introduces Haemate® human plasma coagulation factor VIII
Factor VIII
Factor VIII is an essential blood clotting factor also known as anti-hemophilic factor . In humans, Factor VIII is encoded by the F8 gene...
/von Willebrand factor
Von Willebrand factor
von Willebrand factor is a blood glycoprotein involved in hemostasis. It is deficient or defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic-uremic syndrome...
complex for the treatment of patients with hemophilia A.
1991: CSL Limited is incorporated in Australia.
2000: ZLB Bioplasma (a predecessor company) is established, acquiring the plasma fractionation assets from SRK, a nonprofit organization affiliated with the Swiss Red Cross
Swiss Red Cross
The Swiss Red Cross is the national Red Cross society for Switzerland.It was founded in 1866 in Bern, Switzerland...
. ZLB becomes the fifth largest manufacturer of plasma products worldwide.
2001: Aventis Behring (a predecessor company) acquires 42 plasma centers, forming the world's largest plasma collection business.
2004: CSL Limited completes the acquisition of Aventis Behring, combining it with ZLB Bioplasma to create ZLB Behring (later CSL Behring).
2007: ZLB Behring becomes CSL Behring.
2009: ZLB Plasma changes its name to CSL Plasma to align with its parent company, CSL Behring, and opens the world's largest and most advanced plasma testing laboratories in Knoxville, Tennessee.
Products
CSL Behring researches, develops, manufactures and markets a range of plasma-derived and recombinant products and related services, specializing in the treatment of rare and serious diseases. Its line of therapies includes products for the treatment of hemophilia, von Willebrand Disease, and other bleeding disorders; immune deficiencies including primary immunodeficiency diseases (PIDD); hereditary angioedema and inherited respiratory disease. The company's products are also used in cardiac surgery, organ transplantation, burn treatment and to prevent hemolytic diseases in newborns.[1]Immunology
Immunology
Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with the physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders ; the...
:
- Hizentra®,Human normal immunoglobulin. Liquid 20% immunoglobulin solution, ready-to-use for subcutaneous administration
- Privigen®, human polyvalent immunoglobulin, liquid 10% solution for intravenous injection
- Vivaglobin®, human normal immunoglobulin, liquid 16% solution for subcutaneous administration
- Carimune® NF, Sandoglobulin®, Sanglopor® human normal immunoglobulin, freeze-dried formulations for intravenous administration
- Sandoglobulin ® NF Liquid, Redimune®, Redimune® NF Liquid, human normal immunoglobulin, liquid 12% solution for intravenous administration
- Rhophylac® human anti-D immunoglobulin. Prefilled syringes of highly purified anti-Rhesus factor D IgG for intravenous administration and intramuscular injection.
- Cytogam®, human cytomegalovirusCytomegalovirusCytomegalovirus is a viral genus of the viral group known as Herpesviridae or herpesviruses. It is typically abbreviated as CMV: The species that infects humans is commonly known as human CMV or human herpesvirus-5 , and is the most studied of all cytomegaloviruses...
immunoglobulin. Liquid immunoglobulin containing a standardized amount of antibody to cytomegalovirusCytomegalovirusCytomegalovirus is a viral genus of the viral group known as Herpesviridae or herpesviruses. It is typically abbreviated as CMV: The species that infects humans is commonly known as human CMV or human herpesvirus-5 , and is the most studied of all cytomegaloviruses...
. - Berirab® P, human rabiesRabiesRabies is a viral disease that causes acute encephalitis in warm-blooded animals. It is zoonotic , most commonly by a bite from an infected animal. For a human, rabies is almost invariably fatal if post-exposure prophylaxis is not administered prior to the onset of severe symptoms...
immunoglobulin, liquid 16% solution for intramuscular injection - Beriglobin® P, human hepatitis AHepatitis AHepatitis A is an acute infectious disease of the liver caused by the hepatitis A virus , an RNA virus, usually spread the fecal-oral route; transmitted person-to-person by ingestion of contaminated food or water or through direct contact with an infectious person...
immunoglobulin, liquid 16% solution for intramuscular injection - Hepatitis B Immunoglobulin P Behring, human hepatitis B immunoglobulin, liquid 16% solution for intramuscular injection
- Tetagam® P, human tetanusTetanusTetanus is a medical condition characterized by a prolonged contraction of skeletal muscle fibers. The primary symptoms are caused by tetanospasmin, a neurotoxin produced by the Gram-positive, rod-shaped, obligate anaerobic bacterium Clostridium tetani...
immunoglobulin, liquid 16% solution for intramuscular injection - Varicellon® P, human varicella immunoglobulin, liquid 16% solution for intramuscular injection
- Rhesogamma® P, human anti-D immunoglobulin. Prefilled syringes of highly purified anti-Rhesus factor D IgG for intravenous administration and intramuscular injection.
Coagulation
Coagulation
Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis, the cessation of blood loss from a damaged vessel, wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel...
/Bleeding Disorders:
- Beriate®, freeze-dried human coagulationCoagulationCoagulation is a complex process by which blood forms clots. It is an important part of hemostasis, the cessation of blood loss from a damaged vessel, wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel...
factor VIIIFactor VIIIFactor VIII is an essential blood clotting factor also known as anti-hemophilic factor . In humans, Factor VIII is encoded by the F8 gene...
concentrate - Berinin® P, freeze-dried human coagulationCoagulationCoagulation is a complex process by which blood forms clots. It is an important part of hemostasis, the cessation of blood loss from a damaged vessel, wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel...
factor IXFactor IXFactor IX is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes hemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to...
concentrate - Helixate® FS and Helixate® NexGen, freeze-dried recombinantRecombinant DNARecombinant DNA molecules are DNA sequences that result from the use of laboratory methods to bring together genetic material from multiple sources, creating sequences that would not otherwise be found in biological organisms...
coagulationCoagulationCoagulation is a complex process by which blood forms clots. It is an important part of hemostasis, the cessation of blood loss from a damaged vessel, wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel...
factor VIIIFactor VIIIFactor VIII is an essential blood clotting factor also known as anti-hemophilic factor . In humans, Factor VIII is encoded by the F8 gene... - Humate-P® and Haemate® P, freeze-dried human coagulationCoagulationCoagulation is a complex process by which blood forms clots. It is an important part of hemostasis, the cessation of blood loss from a damaged vessel, wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel...
factor VIIIFactor VIIIFactor VIII is an essential blood clotting factor also known as anti-hemophilic factor . In humans, Factor VIII is encoded by the F8 gene...
: C and von Willebrand factorVon Willebrand factorvon Willebrand factor is a blood glycoprotein involved in hemostasis. It is deficient or defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possibly hemolytic-uremic syndrome...
concentrate - Monoclate P®, a freeze-dried monoclonal antibody purified human coagulationCoagulationCoagulation is a complex process by which blood forms clots. It is an important part of hemostasis, the cessation of blood loss from a damaged vessel, wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel...
factor VIIIFactor VIIIFactor VIII is an essential blood clotting factor also known as anti-hemophilic factor . In humans, Factor VIII is encoded by the F8 gene...
concentrate - Mononine®, a freeze-dried human coagulation factor IXFactor IXFactor IX is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes hemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to...
that has been purified using monoclonal antibodies - Stimate®, a synthetic desmopressinDesmopressinDesmopressin is a synthetic replacement for vasopressin, the hormone that reduces urine production. It may be taken nasally, intravenously, or as a tablet...
acetate nasal spray - Factor X P Behring, a freeze-dried human coagulationCoagulationCoagulation is a complex process by which blood forms clots. It is an important part of hemostasis, the cessation of blood loss from a damaged vessel, wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel...
factor IXFactor IXFactor IX is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes hemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to...
and factor XFactor XFactor X, also known by the eponym Stuart-Prower factor or as prothrombinase, is an enzyme of the coagulation cascade. It is a serine endopeptidase .-Physiology:...
concentrate - Fibrogammin® P and Corifact™, freeze-dried human coagulationCoagulationCoagulation is a complex process by which blood forms clots. It is an important part of hemostasis, the cessation of blood loss from a damaged vessel, wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel...
factor XIIIFactor XIIIFactor XIII or fibrin stabilizing factor is an enzyme of the blood coagulation system that crosslinks fibrin.- Function :Factor XIII is a transglutaminase that circulates in the plasma as a heterotetramer of two catalytic A subunits and two carrier B subunits...
concentrate - Octostim®, a synthetic desmopressinDesmopressinDesmopressin is a synthetic replacement for vasopressin, the hormone that reduces urine production. It may be taken nasally, intravenously, or as a tablet...
acetate nasal spray
Pulmonary:
- Zemaira®, freeze-dried Human Alpha1-proteinase inhibitor (A1-PI)
Critical Care
Critical care
Critical care may refer to:* Critical care medicine or intensive-care medicine, a branch of medicine concerned with life support for critically ill patients* "Critical Care" , an episode of the TV series...
:
- Beriplex® P/N, freeze-dried human prothrombin complex concentrate
- Haemocomplettan® P, RiaSTAP™, freeze-dried human fibrinogenFibrinogenFibrinogen is a soluble plasma glycoprotein, synthesised by the liver, that is converted by thrombin into fibrin during blood coagulation. This is achieved through processes in the coagulation cascade that activate the zymogen prothrombin to the serine protease thrombin, which is responsible for...
(factor I) concentrate - Kybernin® P, freeze-dried human antithrombinAntithrombinAntithrombin is a small protein molecule that inactivates several enzymes of the coagulation system. Antithrombin is a glycoprotein produced by the liver and consists of 432 amino acids. It contains three disulfide bonds and a total of four possible glycosylation sites...
III concentrate - AlbuRx®, Alburex, Human Albumin Behring, Albuminar® 25, human albuminAlbuminAlbumin refers generally to any protein that is water soluble, which is moderately soluble in concentrated salt solutions, and experiences heat denaturation. They are commonly found in blood plasma, and are unique to other blood proteins in that they are not glycosylated...
solution (5%, 20% or 25% human albumin solutions) - Berinert® P, freeze-dried human C1-esterase inhibitor (C1-INH) concentrate
- Streptase®, freeze-dried streptokinaseStreptokinaseStreptokinase , a protein secreted by several species of streptococci can bind and activate human plasminogen. SK is used as an effective and inexpensive thrombolysis medication in some cases of myocardial infarction and pulmonary embolism...
Wound Healing:
- Beriplast® P Combi-Set, fibrin sealant kit, freeze-dried fibrin sealant for topical application
- Fibrogammin® P, freeze-dried human coagulationCoagulationCoagulation is a complex process by which blood forms clots. It is an important part of hemostasis, the cessation of blood loss from a damaged vessel, wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel...
factor XIIIFactor XIIIFactor XIII or fibrin stabilizing factor is an enzyme of the blood coagulation system that crosslinks fibrin.- Function :Factor XIII is a transglutaminase that circulates in the plasma as a heterotetramer of two catalytic A subunits and two carrier B subunits...
concentrate - TachoComb®, fibrin sealant fleece-type, fleece-type collagen preparations coated with fibrin glueFibrin glueFibrin glue is a formulation used to create a fibrin clot. It is made up of fibrinogen and thrombin that are injected through one head into the site of a fibrin tear. Thrombin is an enzyme and converts the fibrinogen into fibrin between 10 and 60 seconds and acts as a tissue adhesive. It may also...
components
(Note: Product availability varies from country to country, depending on registration status.)
Offices
The company is headquartered in King of Prussia, PennsylvaniaKing of Prussia, Pennsylvania
King of Prussia is a census-designated place in Upper Merion Township, Montgomery County, Pennsylvania, United States. As of the 2010 census, its population was 19,936. The community took its name in the 18th century from a local tavern named the King of Prussia Inn, which was named after...
. It has 9,000+ employees in 19 countries. Major manufacturing centers are located in Bern, Switzerland, Marburg, Germany
and Kankakee, Illinois
Kankakee, Illinois
Kankakee is a city in Kankakee County, Illinois, USA. As of the 2000 census, the city population was 25,561, and 26,840 as of a 2009 estimate. It is the county seat of Kankakee County...
.