C-terminal-binding protein 2 also known as CtBP2 is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the CTBP2 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

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Function

This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor (corepressor), while the other isoform is a major component of specialized synapses known as synaptic ribbon

Ribbon synapse

Ribbon synapse is a type of synapse linking some particular neuronal cells, which have unique features, such as their morphology, mechanisms of multivesicular release and calcium channel positioning which promote high speed of neurotransmitter release and an ongoing cycle of exocytosis and...

s. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.

Interactions

CTBP2 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with FHL3

FHL3

Four and a half LIM domains protein 3 is a protein that in humans is encoded by the FHL3 gene.-Interactions:FHL3 has been shown to interact with FHL2, CTBP2, KLF3, ITGA7 and CREB1.-Further reading:...

, SOX6

SOX6

Transcription factor SOX-6 is a protein that in humans is encoded by the SOX6 gene.-Interactions:SOX6 has been shown to interact with CTBP2 and CENPK....

, KLF3

KLF3

Krueppel-like factor 3 is a protein that in humans is encoded by the KLF3 gene.KLF3 is a member of the Krüppel-like factors family of transcription factors. KLF3 primarily represses transcription through the transcriptional corepressor C-terminal binding protein...

, NRIP1

NRIP1

Nuclear receptor-interacting protein 1 is a protein that in humans is encoded by the NRIP1 gene.RIP140 has an important role in regulating lipid and glucose metabolism, and regulates gene expression in metabolic tissues including heart, skeletal muscle, and liver.Knockout mice that completely lack...

, ZFPM2

ZFPM2

Zinc finger protein ZFPM2 is a protein that in humans is encoded by the ZFPM2 gene.-Interactions:ZFPM2 has been shown to interact with GATA4, GATA1 and CTBP2.-Further reading:...

, Mdm2

Mdm2

Mdm2 is an important negative regulator of the p53 tumor suppressor. It is the name of a gene as well as the protein encoded by that gene. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain of the p53 tumor suppressor and an inhibitor of...

 and KLF8

KLF8

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene....

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