KLF3
Encyclopedia
Krueppel-like factor 3 is a protein
that in humans is encoded by the KLF3 gene
.KLF3 is a member of the Krüppel-like factors
family of transcription factors. KLF3 primarily represses transcription through the transcriptional corepressor C-terminal binding protein (CtBP). KLF3's PVDLT (amino acids 61-65) domain, present in its N-terminal variable region, is necessary for its interaction with CtBP. The repression mediated through KLF3 is also partially dependent on the sumoylation of its K10 and K197. Within KLF3's C-terminal, which is highly conserved throughout the KLF family, resides three C2H2 zinc finger
s that preferentially bind the site NRG GNG NGR (where R is a purine
).
with FHL3
and CTBP2
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the KLF3 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.KLF3 is a member of the Krüppel-like factors
Kruppel-like factors
The Krüppel-like family of transcription factors , so named for their homology to the Drosophila melanogaster Krüppel protein, have been extensively studied for their roles in cell proliferation, differentiation and survival, especially in the context of cancer . All KLF family members are...
family of transcription factors. KLF3 primarily represses transcription through the transcriptional corepressor C-terminal binding protein (CtBP). KLF3's PVDLT (amino acids 61-65) domain, present in its N-terminal variable region, is necessary for its interaction with CtBP. The repression mediated through KLF3 is also partially dependent on the sumoylation of its K10 and K197. Within KLF3's C-terminal, which is highly conserved throughout the KLF family, resides three C2H2 zinc finger
Zinc finger
Zinc fingers are small protein structural motifs that can coordinate one or more zinc ions to help stabilize their folds. They can be classified into several different structural families and typically function as interaction modules that bind DNA, RNA, proteins, or small molecules...
s that preferentially bind the site NRG GNG NGR (where R is a purine
Purine
A purine is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. Purines, including substituted purines and their tautomers, are the most widely distributed kind of nitrogen-containing heterocycle in nature....
).
Interactions
KLF3 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with FHL3
FHL3
Four and a half LIM domains protein 3 is a protein that in humans is encoded by the FHL3 gene.-Interactions:FHL3 has been shown to interact with FHL2, CTBP2, KLF3, ITGA7 and CREB1.-Further reading:...
and CTBP2
CTBP2
C-terminal-binding protein 2 also known as CtBP2 is a protein that in humans is encoded by the CTBP2 gene.- Function :This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor , while the other isoform is a major component of specialized...
.